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Auteur Jingyun LI |
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Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism / Shannon ROSE in Autism Research and Treatment, (September 2011)
[article]
Titre : Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Shannon ROSE, Auteur ; Stepan MELNYK, Auteur ; Timothy A. TRUSTY, Auteur ; Oleksandra PAVLIV, Auteur ; Lisa SEIDEL, Auteur ; Jingyun LI, Auteur ; Todd NICK, Auteur ; S. Jill JAMES, Auteur Année de publication : 2011 Article en page(s) : 10 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The modulation of the redox microenvironment is an important regulator of immune cell activation and proliferation. To investigate immune cell redox status in autism we quantified the intracellular glutathione redox couple (GSH/GSSG) in resting peripheral blood mononuclear cells (PBMCs), activated monocytes and CD4 T cells and the extracellular cysteine/cystine redox couple in the plasma from 43 children with autism and 41 age-matched control children. Resting PBMCs and activated monocytes from children with autism exhibited significantly higher oxidized glutathione (GSSG) and percent oxidized glutathione equivalents and decreased glutathione redox status (GSH/GSSG). In activated CD4 T cells from children with autism, the percent oxidized glutathione equivalents were similarly increased, and GSH and GSH/GSSG were decreased. In the plasma, both glutathione and cysteine redox ratios were decreased in autistic compared to control children. Consistent with decreased intracellular and extracellular redox status, generation of free radicals was significantly elevated in lymphocytes from the autistic children. These data indicate primary immune cells from autistic children have a more oxidized intracellular and extracellular microenvironment and a deficit in glutathione-mediated redox/antioxidant capacity compared to control children. These results suggest that the loss of glutathione redox homeostasis and chronic oxidative stress may contribute to immune dysregulation in autism. En ligne : http://dx.doi.org/10.1155/2012/986519 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149
in Autism Research and Treatment > (September 2011) . - 10 p.[article] Intracellular and Extracellular Redox Status and Free Radical Generation in Primary Immune Cells from Children with Autism [Texte imprimé et/ou numérique] / Shannon ROSE, Auteur ; Stepan MELNYK, Auteur ; Timothy A. TRUSTY, Auteur ; Oleksandra PAVLIV, Auteur ; Lisa SEIDEL, Auteur ; Jingyun LI, Auteur ; Todd NICK, Auteur ; S. Jill JAMES, Auteur . - 2011 . - 10 p.
Langues : Anglais (eng)
in Autism Research and Treatment > (September 2011) . - 10 p.
Index. décimale : PER Périodiques Résumé : The modulation of the redox microenvironment is an important regulator of immune cell activation and proliferation. To investigate immune cell redox status in autism we quantified the intracellular glutathione redox couple (GSH/GSSG) in resting peripheral blood mononuclear cells (PBMCs), activated monocytes and CD4 T cells and the extracellular cysteine/cystine redox couple in the plasma from 43 children with autism and 41 age-matched control children. Resting PBMCs and activated monocytes from children with autism exhibited significantly higher oxidized glutathione (GSSG) and percent oxidized glutathione equivalents and decreased glutathione redox status (GSH/GSSG). In activated CD4 T cells from children with autism, the percent oxidized glutathione equivalents were similarly increased, and GSH and GSH/GSSG were decreased. In the plasma, both glutathione and cysteine redox ratios were decreased in autistic compared to control children. Consistent with decreased intracellular and extracellular redox status, generation of free radicals was significantly elevated in lymphocytes from the autistic children. These data indicate primary immune cells from autistic children have a more oxidized intracellular and extracellular microenvironment and a deficit in glutathione-mediated redox/antioxidant capacity compared to control children. These results suggest that the loss of glutathione redox homeostasis and chronic oxidative stress may contribute to immune dysregulation in autism. En ligne : http://dx.doi.org/10.1155/2012/986519 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149