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Auteur Ye DUAN |
Documents disponibles écrits par cet auteur (2)
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Facial phenotypes in subgroups of prepubertal boys with autism spectrum disorders are correlated with clinical phenotypes / Kristina ALDRIDGE in Molecular Autism, (October 2011)
[article]
Titre : Facial phenotypes in subgroups of prepubertal boys with autism spectrum disorders are correlated with clinical phenotypes Type de document : Texte imprimé et/ou numérique Auteurs : Kristina ALDRIDGE, Auteur ; Ian GEORGE, Auteur ; Kimberly COLE, Auteur ; Jordan AUSTIN, Auteur ; T. Nicole TAKAHASHI, Auteur ; Ye DUAN, Auteur ; Judith H. MILES, Auteur Année de publication : 2011 Article en page(s) : 12 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND:The brain develops in concert and in coordination with the developing facial tissues, with each influencing the development of the other and sharing genetic signaling pathways. Autism spectrum disorders (ASDs) result from alterations in the embryological brain, suggesting that the development of the faces of children with ASD may result in subtle facial differences compared to typically developing children. In this study, we tested two hypotheses. First, we asked whether children with ASD display a subtle but distinct facial phenotype compared to typically developing children. Second, we sought to determine whether there are subgroups of facial phenotypes within the population of children with ASD that denote biologically discrete subgroups.METHODS:The 3dMD cranial System was used to acquire three-dimensional stereophotogrammetric images for our study sample of 8- to 12-year-old boys diagnosed with essential ASD (n = 65) and typically developing boys (n = 41) following approved Institutional Review Board protocols. Three-dimensional coordinates were recorded for 17 facial anthropometric landmarks using the 3dMD Patient software. Statistical comparisons of facial phenotypes were completed using Euclidean Distance Matrix Analysis and Principal Coordinates Analysis. Data representing clinical and behavioral traits were statistically compared among groups by using chi2 tests, Fisher's exact tests, Kolmogorov-Smirnov tests and Student's t-tests where appropriate.RESULTS:First, we found that there are significant differences in facial morphology in boys with ASD compared to typically developing boys. Second, we also found two subgroups of boys with ASD with facial morphology that differed from the majority of the boys with ASD and the typically developing boys. Furthermore, membership in each of these distinct subgroups was correlated with particular clinical and behavioral traits.CONCLUSIONS:Boys with ASD display a facial phenotype distinct from that of typically developing boys, which may reflect alterations in the prenatal development of the brain. Subgroups of boys with ASD defined by distinct facial morphologies correlated with clinical and behavioral traits, suggesting potentially different etiologies and genetic differences compared to the larger group of boys with ASD. Further investigations into genes involved in neurodevelopment and craniofacial development of these subgroups will help to elucidate the causes and significance of these subtle facial differences. En ligne : http://dx.doi.org/10.1186/2040-2392-2-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149
in Molecular Autism > (October 2011) . - 12 p.[article] Facial phenotypes in subgroups of prepubertal boys with autism spectrum disorders are correlated with clinical phenotypes [Texte imprimé et/ou numérique] / Kristina ALDRIDGE, Auteur ; Ian GEORGE, Auteur ; Kimberly COLE, Auteur ; Jordan AUSTIN, Auteur ; T. Nicole TAKAHASHI, Auteur ; Ye DUAN, Auteur ; Judith H. MILES, Auteur . - 2011 . - 12 p.
Langues : Anglais (eng)
in Molecular Autism > (October 2011) . - 12 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND:The brain develops in concert and in coordination with the developing facial tissues, with each influencing the development of the other and sharing genetic signaling pathways. Autism spectrum disorders (ASDs) result from alterations in the embryological brain, suggesting that the development of the faces of children with ASD may result in subtle facial differences compared to typically developing children. In this study, we tested two hypotheses. First, we asked whether children with ASD display a subtle but distinct facial phenotype compared to typically developing children. Second, we sought to determine whether there are subgroups of facial phenotypes within the population of children with ASD that denote biologically discrete subgroups.METHODS:The 3dMD cranial System was used to acquire three-dimensional stereophotogrammetric images for our study sample of 8- to 12-year-old boys diagnosed with essential ASD (n = 65) and typically developing boys (n = 41) following approved Institutional Review Board protocols. Three-dimensional coordinates were recorded for 17 facial anthropometric landmarks using the 3dMD Patient software. Statistical comparisons of facial phenotypes were completed using Euclidean Distance Matrix Analysis and Principal Coordinates Analysis. Data representing clinical and behavioral traits were statistically compared among groups by using chi2 tests, Fisher's exact tests, Kolmogorov-Smirnov tests and Student's t-tests where appropriate.RESULTS:First, we found that there are significant differences in facial morphology in boys with ASD compared to typically developing boys. Second, we also found two subgroups of boys with ASD with facial morphology that differed from the majority of the boys with ASD and the typically developing boys. Furthermore, membership in each of these distinct subgroups was correlated with particular clinical and behavioral traits.CONCLUSIONS:Boys with ASD display a facial phenotype distinct from that of typically developing boys, which may reflect alterations in the prenatal development of the brain. Subgroups of boys with ASD defined by distinct facial morphologies correlated with clinical and behavioral traits, suggesting potentially different etiologies and genetic differences compared to the larger group of boys with ASD. Further investigations into genes involved in neurodevelopment and craniofacial development of these subgroups will help to elucidate the causes and significance of these subtle facial differences. En ligne : http://dx.doi.org/10.1186/2040-2392-2-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=149 Facial Structure Analysis Separates Autism Spectrum Disorders into Meaningful Clinical Subgroups / Tayo OBAFEMI-AJAYI in Journal of Autism and Developmental Disorders, 45-5 (May 2015)
[article]
Titre : Facial Structure Analysis Separates Autism Spectrum Disorders into Meaningful Clinical Subgroups Type de document : Texte imprimé et/ou numérique Auteurs : Tayo OBAFEMI-AJAYI, Auteur ; Judith H. MILES, Auteur ; T. Nicole TAKAHASHI, Auteur ; Wenchuan QI, Auteur ; Kristina ALDRIDGE, Auteur ; Minqi ZHANG, Auteur ; Shi-Qing XIN, Auteur ; Ying HE, Auteur ; Ye DUAN, Auteur Article en page(s) : p.1302-1317 Langues : Anglais (eng) Mots-clés : Autism Cluster analysis Language regression Facial phenotype Biomarker Outcome indicators Index. décimale : PER Périodiques Résumé : Varied cluster analysis were applied to facial surface measurements from 62 prepubertal boys with essential autism to determine whether facial morphology constitutes viable biomarker for delineation of discrete Autism Spectrum Disorders (ASD) subgroups. Earlier study indicated utility of facial morphology for autism subgrouping (Aldridge et al. in Mol Autism 2(1):15, 2011). Geodesic distances between standardized facial landmarks were measured from three-dimensional stereo-photogrammetric images. Subjects were evaluated for autism-related symptoms, neurologic, cognitive, familial, and phenotypic variants. The most compact cluster is clinically characterized by severe ASD, significant cognitive impairment and language regression. This verifies utility of facially-based ASD subtypes and validates Aldridge et al.’s severe ASD subgroup, notwithstanding different techniques. It suggests that language regression may define a unique ASD subgroup with potential etiologic differences. En ligne : http://dx.doi.org/10.1007/s10803-014-2290-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1302-1317[article] Facial Structure Analysis Separates Autism Spectrum Disorders into Meaningful Clinical Subgroups [Texte imprimé et/ou numérique] / Tayo OBAFEMI-AJAYI, Auteur ; Judith H. MILES, Auteur ; T. Nicole TAKAHASHI, Auteur ; Wenchuan QI, Auteur ; Kristina ALDRIDGE, Auteur ; Minqi ZHANG, Auteur ; Shi-Qing XIN, Auteur ; Ying HE, Auteur ; Ye DUAN, Auteur . - p.1302-1317.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-5 (May 2015) . - p.1302-1317
Mots-clés : Autism Cluster analysis Language regression Facial phenotype Biomarker Outcome indicators Index. décimale : PER Périodiques Résumé : Varied cluster analysis were applied to facial surface measurements from 62 prepubertal boys with essential autism to determine whether facial morphology constitutes viable biomarker for delineation of discrete Autism Spectrum Disorders (ASD) subgroups. Earlier study indicated utility of facial morphology for autism subgrouping (Aldridge et al. in Mol Autism 2(1):15, 2011). Geodesic distances between standardized facial landmarks were measured from three-dimensional stereo-photogrammetric images. Subjects were evaluated for autism-related symptoms, neurologic, cognitive, familial, and phenotypic variants. The most compact cluster is clinically characterized by severe ASD, significant cognitive impairment and language regression. This verifies utility of facially-based ASD subtypes and validates Aldridge et al.’s severe ASD subgroup, notwithstanding different techniques. It suggests that language regression may define a unique ASD subgroup with potential etiologic differences. En ligne : http://dx.doi.org/10.1007/s10803-014-2290-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259