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Détail de l'auteur
Auteur Lucas POZZO-MILLER |
Documents disponibles écrits par cet auteur (2)
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Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice / Wei LI in Autism - Open Access, 2-S ([01/12/2012])
[article]
Titre : Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice Type de document : Texte imprimé et/ou numérique Auteurs : Wei LI, Auteur ; Lucas POZZO-MILLER, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Rett syndrome (RTT) is one of the leading causes of intellectual disabilities in women. In addition to a few autistic features, characteristic symptoms that distinguish from classical autism include stereotypic hand movements, motor coordination deficits, breathing abnormalities, seizures and loss of acquired speech as well as purposeful hand use. RTT is highly associated with MECP2, the gene encoding for the transcription factor that binds methylated Cytosine in C-p-G islands in DNA, controlling gene expression and chromatin remodeling. In this review, we will briefly discuss current perspectives on MeCP2 function, and then will describe in detail novel mouse models of RTT based on loss-of-function of Mecp2 and their use for establishing rescue models, wherein we pay close attention to behavioral and morphological phenotypes. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 2-S [01/12/2012] . - 7 p.[article] Beyond Widespread Mecp2 Deletions to Model Rett Syndrome: Conditional Spatio-Temporal Knockout, Single-Point Mutations and Transgenic Rescue Mice [Texte imprimé et/ou numérique] / Wei LI, Auteur ; Lucas POZZO-MILLER, Auteur . - 7 p.
Langues : Anglais (eng)
in Autism - Open Access > 2-S [01/12/2012] . - 7 p.
Index. décimale : PER Périodiques Résumé : Rett syndrome (RTT) is one of the leading causes of intellectual disabilities in women. In addition to a few autistic features, characteristic symptoms that distinguish from classical autism include stereotypic hand movements, motor coordination deficits, breathing abnormalities, seizures and loss of acquired speech as well as purposeful hand use. RTT is highly associated with MECP2, the gene encoding for the transcription factor that binds methylated Cytosine in C-p-G islands in DNA, controlling gene expression and chromatin remodeling. In this review, we will briefly discuss current perspectives on MeCP2 function, and then will describe in detail novel mouse models of RTT based on loss-of-function of Mecp2 and their use for establishing rescue models, wherein we pay close attention to behavioral and morphological phenotypes. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 Rett syndrome: On Clinical and Genetic Features, and Experimental Models based on Mecp2 dysfunction / Gaston CALFA
Titre : Rett syndrome: On Clinical and Genetic Features, and Experimental Models based on Mecp2 dysfunction Type de document : Texte imprimé et/ou numérique Auteurs : Gaston CALFA, Auteur ; Alan K. PERCY, Auteur ; Lucas POZZO-MILLER, Auteur Année de publication : 2013 Importance : p.57-90 Langues : Anglais (eng) Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Rett syndrome: On Clinical and Genetic Features, and Experimental Models based on Mecp2 dysfunction [Texte imprimé et/ou numérique] / Gaston CALFA, Auteur ; Alan K. PERCY, Auteur ; Lucas POZZO-MILLER, Auteur . - 2013 . - p.57-90.
Langues : Anglais (eng)
Index. décimale : SCI-D SCI-D - Neurosciences Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=189 Exemplaires
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