Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur M. M. ESSA |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Impaired antioxidant status and reduced energy metabolism in autistic children / M. M. ESSA in Research in Autism Spectrum Disorders, 7-5 (May 2013)
[article]
Titre : Impaired antioxidant status and reduced energy metabolism in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : M. M. ESSA, Auteur ; N. BRAIDY, Auteur ; M. I. WALY, Auteur ; Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; S. SUBASH, Auteur ; A. AMANAT, Auteur ; M. A. AL-SHAFFAEE, Auteur ; G. J. GUILLEMIN, Auteur Article en page(s) : p.557-565 Mots-clés : Autism ATP Oxidative stress NAD+ Antioxidants Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that oxidative stress induced mechanisms are believed to be associated with the pathophysiology of autism. In this study, we recruited 19 Omani autistic children with age-matched controls to analyze their plasma and serum redox status and the levels of ATP, NAD+ and NADH using well established spectrophotometric assays. A significant decrease was observed in the levels of plasma total antioxidants (TA), reduced glutathione (GSH), superoxide and catalase activity in Omani autistic children as compared to their age-matched controls. In contrary, the level of plasma glutathione peroxidase (GSH-Px) was significantly increased in autistic children. Reduced serum NAD+ and ATP levels and lower NAD+:NADH ratio were observedin patients with autism compared to controls. Finally, a significant inverse correlation was observed between plasma GSH, SOD, catalase activity, and serum NAD+ and ATP levels, and autism severity using Childhood Autism Rating Scale (CARS) scores. The levels of plasma GSH-Px and serum NADH correlated strongly with autism severity whilst no significant correlation was observed for plasma TA. Our data suggests that increased vulnerability to oxidative stress in autism may occur as a consequence of alterations in antioxidant enzymes leading to mitochondrial dysfunction. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.557-565[article] Impaired antioxidant status and reduced energy metabolism in autistic children [Texte imprimé et/ou numérique] / M. M. ESSA, Auteur ; N. BRAIDY, Auteur ; M. I. WALY, Auteur ; Yahya M. AL-FARSI, Auteur ; Marwan M. AL-SHARBATI, Auteur ; S. SUBASH, Auteur ; A. AMANAT, Auteur ; M. A. AL-SHAFFAEE, Auteur ; G. J. GUILLEMIN, Auteur . - p.557-565.
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.557-565
Mots-clés : Autism ATP Oxidative stress NAD+ Antioxidants Index. décimale : PER Périodiques Résumé : Accumulating evidence suggests that oxidative stress induced mechanisms are believed to be associated with the pathophysiology of autism. In this study, we recruited 19 Omani autistic children with age-matched controls to analyze their plasma and serum redox status and the levels of ATP, NAD+ and NADH using well established spectrophotometric assays. A significant decrease was observed in the levels of plasma total antioxidants (TA), reduced glutathione (GSH), superoxide and catalase activity in Omani autistic children as compared to their age-matched controls. In contrary, the level of plasma glutathione peroxidase (GSH-Px) was significantly increased in autistic children. Reduced serum NAD+ and ATP levels and lower NAD+:NADH ratio were observedin patients with autism compared to controls. Finally, a significant inverse correlation was observed between plasma GSH, SOD, catalase activity, and serum NAD+ and ATP levels, and autism severity using Childhood Autism Rating Scale (CARS) scores. The levels of plasma GSH-Px and serum NADH correlated strongly with autism severity whilst no significant correlation was observed for plasma TA. Our data suggests that increased vulnerability to oxidative stress in autism may occur as a consequence of alterations in antioxidant enzymes leading to mitochondrial dysfunction. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194