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Auteur Laura B. K. HERZING |
Documents disponibles écrits par cet auteur (1)
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Gene × Environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children / John V. LAVIGNE in Development and Psychopathology, 25-2 (May 2013)
[article]
Titre : Gene × Environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children Type de document : Texte imprimé et/ou numérique Auteurs : John V. LAVIGNE, Auteur ; Laura B. K. HERZING, Auteur ; Edwin H. Jr COOK, Auteur ; Susan A. LEBAILLY, Auteur ; Karen R. GOUZE, Auteur ; Joyce HOPKINS, Auteur ; Fred B. BRYANT, Auteur Article en page(s) : p.555-575 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Genetic factors can play a key role in the multiple level of analyses approach to understanding the development of child psychopathology. The present study examined gene–environment correlations and Gene × Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine receptor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter linked polymorphic repeat, the long form (l/l) was associated with greater increases in symptoms of oppositional defiant disorder in interaction with family stress and with greater increases in symptoms of child depression and anxiety in interaction with caretaker depression, family conflict, and socioeconomic status. In boys, low-activity monoamine oxidase A gene was associated with increases in child anxiety and depression in interaction with caretaker depression, hostility, family conflict, and family stress. The results highlight the important of gene–environment interplay in the development of symptoms of child psychopathology in young children. En ligne : http://dx.doi.org/10.1017/S0954579412001241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199
in Development and Psychopathology > 25-2 (May 2013) . - p.555-575[article] Gene × Environment effects of serotonin transporter, dopamine receptor D4, and monoamine oxidase A genes with contextual and parenting risk factors on symptoms of oppositional defiant disorder, anxiety, and depression in a community sample of 4-year-old children [Texte imprimé et/ou numérique] / John V. LAVIGNE, Auteur ; Laura B. K. HERZING, Auteur ; Edwin H. Jr COOK, Auteur ; Susan A. LEBAILLY, Auteur ; Karen R. GOUZE, Auteur ; Joyce HOPKINS, Auteur ; Fred B. BRYANT, Auteur . - p.555-575.
Langues : Anglais (eng)
in Development and Psychopathology > 25-2 (May 2013) . - p.555-575
Index. décimale : PER Périodiques Résumé : Genetic factors can play a key role in the multiple level of analyses approach to understanding the development of child psychopathology. The present study examined gene–environment correlations and Gene × Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine receptor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter linked polymorphic repeat, the long form (l/l) was associated with greater increases in symptoms of oppositional defiant disorder in interaction with family stress and with greater increases in symptoms of child depression and anxiety in interaction with caretaker depression, family conflict, and socioeconomic status. In boys, low-activity monoamine oxidase A gene was associated with increases in child anxiety and depression in interaction with caretaker depression, hostility, family conflict, and family stress. The results highlight the important of gene–environment interplay in the development of symptoms of child psychopathology in young children. En ligne : http://dx.doi.org/10.1017/S0954579412001241 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=199