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Détail de l'auteur
Auteur Elizabeth KELLEY |
Documents disponibles écrits par cet auteur (27)
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The contribution of epigenetics to understanding genetic factors in autism / Layla HALL in Autism, 18-8 (November 2014)
[article]
Titre : The contribution of epigenetics to understanding genetic factors in autism Type de document : Texte imprimé et/ou numérique Auteurs : Layla HALL, Auteur ; Elizabeth KELLEY, Auteur Article en page(s) : p.872-881 Langues : Anglais (eng) Mots-clés : autism autism spectrum disorder epigenetic genetic Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a grouping of neurodevelopmental disorders characterized by deficits in social communication and language, as well as by repetitive and stereotyped behaviors. While the environment is believed to play a role in the development of autism spectrum disorder, there is now strong evidence for a genetic link to autism. Despite such evidence, studies investigating a potential single-gene cause for autism, although insightful, have been highly inconclusive. A consideration of an epigenetic approach proves to be very promising in clarifying genetic factors involved in autism. The present article is intended to provide a review of key findings pertaining to epigenetics in autism in such a way that a broader audience of individuals who do not have a strong background in genetics may better understand this highly specific and scientific content. Epigenetics refers to non-permanent heritable changes that alter expression of genes without altering the DNA sequence itself and considers the role of environment in this modulation of gene expression. This review provides a brief description of epigenetic processes, highlights evidence in the literature of epigenetic dysregulation in autism, and makes use of noteworthy findings to illustrate how a consideration of epigenetic factors can deepen our understanding of the development of autism. Furthermore, this discussion will present a promising new way for moving forward in the investigation of genetic factors within autism. En ligne : http://dx.doi.org/10.1177/1362361313503501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242
in Autism > 18-8 (November 2014) . - p.872-881[article] The contribution of epigenetics to understanding genetic factors in autism [Texte imprimé et/ou numérique] / Layla HALL, Auteur ; Elizabeth KELLEY, Auteur . - p.872-881.
Langues : Anglais (eng)
in Autism > 18-8 (November 2014) . - p.872-881
Mots-clés : autism autism spectrum disorder epigenetic genetic Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is a grouping of neurodevelopmental disorders characterized by deficits in social communication and language, as well as by repetitive and stereotyped behaviors. While the environment is believed to play a role in the development of autism spectrum disorder, there is now strong evidence for a genetic link to autism. Despite such evidence, studies investigating a potential single-gene cause for autism, although insightful, have been highly inconclusive. A consideration of an epigenetic approach proves to be very promising in clarifying genetic factors involved in autism. The present article is intended to provide a review of key findings pertaining to epigenetics in autism in such a way that a broader audience of individuals who do not have a strong background in genetics may better understand this highly specific and scientific content. Epigenetics refers to non-permanent heritable changes that alter expression of genes without altering the DNA sequence itself and considers the role of environment in this modulation of gene expression. This review provides a brief description of epigenetic processes, highlights evidence in the literature of epigenetic dysregulation in autism, and makes use of noteworthy findings to illustrate how a consideration of epigenetic factors can deepen our understanding of the development of autism. Furthermore, this discussion will present a promising new way for moving forward in the investigation of genetic factors within autism. En ligne : http://dx.doi.org/10.1177/1362361313503501 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=242 Transdiagnostic Patterns of Sensory Processing in Autism and ADHD / Anahid POURTOUSI ; Connie YANG ; Zining DING ; Bobby STOJANOSKI ; Evdokia ANAGNOSTOU ; Robert NICOLSON ; Elizabeth KELLEY ; Stelios GEORGIADES ; Jennifer CROSBIE ; Russell SCHACHAR ; Muhammad AYUB ; Ryan A. STEVENSON in Journal of Autism and Developmental Disorders, 54-1 (January 2024)
[article]
Titre : Transdiagnostic Patterns of Sensory Processing in Autism and ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Anahid POURTOUSI, Auteur ; Connie YANG, Auteur ; Zining DING, Auteur ; Bobby STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Stelios GEORGIADES, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Muhammad AYUB, Auteur ; Ryan A. STEVENSON, Auteur Article en page(s) : p.280-292 Index. décimale : PER Périodiques Résumé : Sensory processing abilities are highly variable within and across people diagnosed with autism and attention-deficit/hyperactivity disorder (ADHD). This study examined the transdiagnostic nature of sensory processing abilities, and their association with features of autism and ADHD, in a large sample of autistic people (n?=?495) and people with ADHD (n?=?461). Five similar data-driven sensory phenotypes characterized sensory processing abilities, and showed similar patterns of association with features of autism and ADHD, across both diagnostic groups. These results demonstrate the transdiagnostic nature of sensory processing abilities, while contributing to a growing body of literature that suggests the autism and ADHD diagnostic labels have poor explanatory power. En ligne : https://doi.org/10.1007/s10803-022-05798-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520
in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.280-292[article] Transdiagnostic Patterns of Sensory Processing in Autism and ADHD [Texte imprimé et/ou numérique] / Anahid POURTOUSI, Auteur ; Connie YANG, Auteur ; Zining DING, Auteur ; Bobby STOJANOSKI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur ; Stelios GEORGIADES, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Muhammad AYUB, Auteur ; Ryan A. STEVENSON, Auteur . - p.280-292.
in Journal of Autism and Developmental Disorders > 54-1 (January 2024) . - p.280-292
Index. décimale : PER Périodiques Résumé : Sensory processing abilities are highly variable within and across people diagnosed with autism and attention-deficit/hyperactivity disorder (ADHD). This study examined the transdiagnostic nature of sensory processing abilities, and their association with features of autism and ADHD, in a large sample of autistic people (n?=?495) and people with ADHD (n?=?461). Five similar data-driven sensory phenotypes characterized sensory processing abilities, and showed similar patterns of association with features of autism and ADHD, across both diagnostic groups. These results demonstrate the transdiagnostic nature of sensory processing abilities, while contributing to a growing body of literature that suggests the autism and ADHD diagnostic labels have poor explanatory power. En ligne : https://doi.org/10.1007/s10803-022-05798-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520