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Auteur Muhammad AYUB |
Documents disponibles écrits par cet auteur (6)
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Characterizing the ASD-ADHD phenotype: measurement structure and invariance in a clinical sample / Aneta D. KRAKOWSKI in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
[article]
Titre : Characterizing the ASD-ADHD phenotype: measurement structure and invariance in a clinical sample Type de document : Texte imprimé et/ou numérique Auteurs : Aneta D. KRAKOWSKI, Auteur ; Katherine Tombeau COST, Auteur ; Peter SZATMARI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Eric DUKU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Elizabeth KELLEY, Auteur ; Rob NICOLSON, Auteur ; Eleanor PULLENAYEGUM, Auteur ; Carolina BARNETT-TAPIA, Auteur Article en page(s) : p.1534-1543 Langues : Anglais (eng) Mots-clés : Humans Attention Deficit Disorder with Hyperactivity/diagnosis/genetics Autism Spectrum Disorder/diagnosis Parents Phenotype Surveys and Questionnaires Adhd Asd factor analysis measurement invariance measurement structure Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) have considerable overlap, supporting the need for a dimensional framework that examines neurodevelopmental domains which cross traditional diagnostic boundaries. In the following study, we use factor analysis to deconstruct the ASD-ADHD phenotype into its underlying phenotypic domains and test for measurement invariance across adaptive functioning, age, gender and ASD/ADHD clinical diagnoses. METHODS: Participants included children and youth (aged 3-20 years) with a clinical diagnosis of ASD (n=727) or ADHD (n=770) for a total of 1,497 participants. Parents of these children completed the Social Communication Questionnaire (SCQ), a measure of autism symptoms, and the Strengths and Weaknesses of ADHD and Normal Behaviour (SWAN) questionnaire, a measure of ADHD symptoms. An exploratory factor analysis (EFA) was performed on combined SCQ and SWAN items. This was followed by a confirmatory factor analysis (CFA) and tests of measurement invariance. RESULTS: EFA revealed a four-factor solution (inattention, hyperactivity/impulsivity, social-communication, and restricted, repetitive, behaviours and interests (RRBI)) and a CFA confirmed good model fit. This solution also showed good model fit across subgroups of interest. CONCLUSIONS: Our study shows that a combined ASD-ADHD phenotype is characterized by two latent ASD domains (social communication and RRBIs) and two latent ADHD domains (inattention and hyperactivity/impulsivity). We established measurement invariance of the derived measurement model across adaptive functioning, age, gender and ASD/ADHD diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.13609 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1534-1543[article] Characterizing the ASD-ADHD phenotype: measurement structure and invariance in a clinical sample [Texte imprimé et/ou numérique] / Aneta D. KRAKOWSKI, Auteur ; Katherine Tombeau COST, Auteur ; Peter SZATMARI, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer CROSBIE, Auteur ; Russell SCHACHAR, Auteur ; Eric DUKU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Elizabeth KELLEY, Auteur ; Rob NICOLSON, Auteur ; Eleanor PULLENAYEGUM, Auteur ; Carolina BARNETT-TAPIA, Auteur . - p.1534-1543.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1534-1543
Mots-clés : Humans Attention Deficit Disorder with Hyperactivity/diagnosis/genetics Autism Spectrum Disorder/diagnosis Parents Phenotype Surveys and Questionnaires Adhd Asd factor analysis measurement invariance measurement structure Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) have considerable overlap, supporting the need for a dimensional framework that examines neurodevelopmental domains which cross traditional diagnostic boundaries. In the following study, we use factor analysis to deconstruct the ASD-ADHD phenotype into its underlying phenotypic domains and test for measurement invariance across adaptive functioning, age, gender and ASD/ADHD clinical diagnoses. METHODS: Participants included children and youth (aged 3-20 years) with a clinical diagnosis of ASD (n=727) or ADHD (n=770) for a total of 1,497 participants. Parents of these children completed the Social Communication Questionnaire (SCQ), a measure of autism symptoms, and the Strengths and Weaknesses of ADHD and Normal Behaviour (SWAN) questionnaire, a measure of ADHD symptoms. An exploratory factor analysis (EFA) was performed on combined SCQ and SWAN items. This was followed by a confirmatory factor analysis (CFA) and tests of measurement invariance. RESULTS: EFA revealed a four-factor solution (inattention, hyperactivity/impulsivity, social-communication, and restricted, repetitive, behaviours and interests (RRBI)) and a CFA confirmed good model fit. This solution also showed good model fit across subgroups of interest. CONCLUSIONS: Our study shows that a combined ASD-ADHD phenotype is characterized by two latent ASD domains (social communication and RRBIs) and two latent ADHD domains (inattention and hyperactivity/impulsivity). We established measurement invariance of the derived measurement model across adaptive functioning, age, gender and ASD/ADHD diagnoses. En ligne : http://dx.doi.org/10.1111/jcpp.13609 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities / Liana KAUFMAN
Titre : Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities Type de document : Texte imprimé et/ou numérique Auteurs : Liana KAUFMAN, Auteur ; Abdul NOOR, Auteur ; Muhammad AYUB, Auteur ; John B. VINCENT, Auteur Année de publication : 2011 Importance : p.126-158 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities [Texte imprimé et/ou numérique] / Liana KAUFMAN, Auteur ; Abdul NOOR, Auteur ; Muhammad AYUB, Auteur ; John B. VINCENT, Auteur . - 2011 . - p.126-158.
Langues : Anglais (eng)
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/18481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD / Calvin P. SJAARDA in Research in Autism Spectrum Disorders, 60 (April 2019)
[article]
Titre : Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur Article en page(s) : p.25-35 Langues : Anglais (eng) Mots-clés : ASD Autism Electroencephalogram DAT1 Dopamine Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387
in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35[article] Homozygosity for the 10-repeat dopamine transporter (DAT1) allele is associated with reduced EEG response in males with ASD [Texte imprimé et/ou numérique] / Calvin P. SJAARDA, Auteur ; Mark A. SABBAGH, Auteur ; Shalandra WOOD, Auteur ; Jessica WARD-KING, Auteur ; Amy J. M. MCNAUGHTON, Auteur ; Melissa L. HUDSON, Auteur ; Mingda TAO, Auteur ; Muhammad AYUB, Auteur ; Xudong LIU, Auteur . - p.25-35.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.25-35
Mots-clés : ASD Autism Electroencephalogram DAT1 Dopamine Face processing Index. décimale : PER Périodiques Résumé : Background Individuals with autism spectrum disorder (ASD) have reduced interest in human faces and atypical event-related brain potentials (ERPs) in response to face stimuli, suggesting that face processing may be a functional marker of ASD susceptibility. Method This report explored the visual processing of individuals with ASD (n?=?50) compared with their first-degree relatives (n?=?117) using electroencephalogram (EEG), and associated EEG response with specific polymorphisms in the COMT, OXTR, SLC6A4 and DAT1 genes. Results Polymorphisms in the COMT and OXTR genes were not associated with any specific EEG response; on the other hand, the 5-HTTLPR polymorphism located upstream of SLC6A4 was associated with increased latency of the P1 component of the EEG response, and DAT1 genotype correlated with reduced amplitude of the N170 component in male participants with ASD. Conclusion These results suggest an interaction between DAT1 genotype and male participants with ASD characterized by reduced cognitive performance when processing faces as measured by EEG. Identifying ASD functional markers and grouping individuals with shared genetic biomarkers or endophenotypes may facilitate greater understanding of the heterogeneity underlying ASD leading to improved diagnosis and treatment of ASD. En ligne : https://doi.org/10.1016/j.rasd.2018.12.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 Investigating language skills as a mediator between IQ and anxiety in autistic youth / Ethan RINALDO in Research in Autism Spectrum Disorders, 88 (October 2021)
[article]
Titre : Investigating language skills as a mediator between IQ and anxiety in autistic youth Type de document : Texte imprimé et/ou numérique Auteurs : Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur Article en page(s) : 101846 Langues : Anglais (eng) Mots-clés : Autism Autism spectrum disorder IQ Language Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101846[article] Investigating language skills as a mediator between IQ and anxiety in autistic youth [Texte imprimé et/ou numérique] / Ethan RINALDO, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Stelios GEORGIADES, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Elizabeth KELLEY, Auteur . - 101846.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101846
Mots-clés : Autism Autism spectrum disorder IQ Language Anxiety Index. décimale : PER Périodiques Résumé : Background Anxiety is a common condition noted to cause significant impairment in some autistic youth. Previous research has found that autistic youth tend to exhibit higher levels of traditional anxiety symptoms with higher IQ scores and higher language abilities. In this study of the relationship between anxiety, intelligence, and language skills in autistic youth, it was hypothesized that a mediational relationship would be observed in which IQ exerts its influence over anxiety through language skills. Method Participants consisted of 293 autistic youth between the ages of 7 and 18. Anxiety was assessed with the Revised Children’s Anxiety and Depression Scale, language with the Oral and Written Language Scales Version II, and IQ (performance, verbal, and full-scale) was measured with the Wechsler Abbreviated Scale of Intelligence Version II. A simple mediation model was used with IQ as the predictor variable, language as the mediator variable, and anxiety as the outcome variable. This analysis was conducted three times so that performance, verbal, and full-scale IQ could be examined as separate predictors. Results The results of this study confirmed our hypothesis with a full mediation effect for each IQ scale, although verbal IQ was too strongly correlated with language scores for it to be considered a separate construct from our language measure. Conclusions This model should inform further autism research in that the influence of IQ and language over anxiety should not be viewed as independent factors but as a set of constructs that exert a shared influence. En ligne : https://doi.org/10.1016/j.rasd.2021.101846 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study / Danielle A. BARIBEAU in Autism Research, 16-8 (August 2023)
[article]
Titre : Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study Type de document : Texte imprimé et/ou numérique Auteurs : Danielle A. BARIBEAU, Auteur ; Jasleen ARNEJA, Auteur ; Xuesong WANG, Auteur ; Jennifer HOWE, Auteur ; John R. MCLAUGHLIN, Auteur ; Karen TU, Auteur ; Jun GUAN, Auteur ; Alana IABONI, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Stephen W. SCHERER, Auteur ; Susan E. BRONSKILL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer D. BROOKS, Auteur Article en page(s) : p.1600-1608 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Whether genetic testing in autism can help understand longitudinal health outcomes and health service needs is unclear. The objective of this study was to determine whether carrying an autism-associated rare genetic variant is associated with differences in health system utilization by autistic children and youth. This retrospective cohort study examined 415 autistic children/youth who underwent genome sequencing and data collection through a translational neuroscience program (Province of Ontario Neurodevelopmental Disorders Network). Participant data were linked to provincial health administrative databases to identify historical health service utilization, health care costs, and complex chronic medical conditions during a 3-year period. Health administrative data were compared between participants with and without a rare genetic variant in at least 1 of 74 genes associated with autism. Participants with a rare variant impacting an autism-associated gene (n=83, 20%) were less likely to have received psychiatric care (at least one psychiatrist visit: 19.3% vs. 34.3%, p=0.01; outpatient mental health visit: 66% vs. 77%, p=0.04). Health care costs were similar between groups (median: $5589 vs. $4938, p=0.4) and genetic status was not associated with odds of being a high-cost participant (top 20%) in this cohort. There were no differences in the proportion with complex chronic medical conditions between those with and without an autism-associated genetic variant. Our study highlights the feasibility and potential value of genomic and health system data linkage to understand health service needs, disparities, and health trajectories in individuals with neurodevelopmental conditions. En ligne : https://doi.org/10.1002/aur.2999 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510
in Autism Research > 16-8 (August 2023) . - p.1600-1608[article] Linkage of whole genome sequencing and administrative health data in autism: A proof of concept study [Texte imprimé et/ou numérique] / Danielle A. BARIBEAU, Auteur ; Jasleen ARNEJA, Auteur ; Xuesong WANG, Auteur ; Jennifer HOWE, Auteur ; John R. MCLAUGHLIN, Auteur ; Karen TU, Auteur ; Jun GUAN, Auteur ; Alana IABONI, Auteur ; Elizabeth KELLEY, Auteur ; Muhammad AYUB, Auteur ; Robert NICOLSON, Auteur ; Stelios GEORGIADES, Auteur ; Stephen W. SCHERER, Auteur ; Susan E. BRONSKILL, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jennifer D. BROOKS, Auteur . - p.1600-1608.
Langues : Anglais (eng)
in Autism Research > 16-8 (August 2023) . - p.1600-1608
Index. décimale : PER Périodiques Résumé : Abstract Whether genetic testing in autism can help understand longitudinal health outcomes and health service needs is unclear. The objective of this study was to determine whether carrying an autism-associated rare genetic variant is associated with differences in health system utilization by autistic children and youth. This retrospective cohort study examined 415 autistic children/youth who underwent genome sequencing and data collection through a translational neuroscience program (Province of Ontario Neurodevelopmental Disorders Network). Participant data were linked to provincial health administrative databases to identify historical health service utilization, health care costs, and complex chronic medical conditions during a 3-year period. Health administrative data were compared between participants with and without a rare genetic variant in at least 1 of 74 genes associated with autism. Participants with a rare variant impacting an autism-associated gene (n=83, 20%) were less likely to have received psychiatric care (at least one psychiatrist visit: 19.3% vs. 34.3%, p=0.01; outpatient mental health visit: 66% vs. 77%, p=0.04). Health care costs were similar between groups (median: $5589 vs. $4938, p=0.4) and genetic status was not associated with odds of being a high-cost participant (top 20%) in this cohort. There were no differences in the proportion with complex chronic medical conditions between those with and without an autism-associated genetic variant. Our study highlights the feasibility and potential value of genomic and health system data linkage to understand health service needs, disparities, and health trajectories in individuals with neurodevelopmental conditions. En ligne : https://doi.org/10.1002/aur.2999 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 Transdiagnostic Patterns of Sensory Processing in Autism and ADHD / Anahid POURTOUSI ; Connie YANG ; Zining DING ; Bobby STOJANOSKI ; Evdokia ANAGNOSTOU ; Robert NICOLSON ; Elizabeth KELLEY ; Stelios GEORGIADES ; Jennifer CROSBIE ; Russell SCHACHAR ; Muhammad AYUB ; Ryan A. STEVENSON in Journal of Autism and Developmental Disorders, 54-1 (January 2024)
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