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Abnormal lateralization of functional connectivity between language and default mode regions in autism / Jared NIELSEN in Molecular Autism, (February 2014) 

Public ISBD [article]  in Molecular Autism > (February 2014) Titre : Abnormal lateralization of functional connectivity between language and default mode regions in autism Type de document : texte imprimé Auteurs : Jared NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey ANDERSON, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2279 [article] Abnormal lateralization of functional connectivity between language and default mode regions in autism [texte imprimé] / Jared NIELSEN, Auteur ; Brandon ZIELINSKI, Auteur ; P FLETCHER, Auteur ; Andrew ALEXANDER, Auteur ; Nicholas LANGE, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Jeffrey ANDERSON, Auteur. Langues : Anglais (eng) in Molecular Autism > (February 2014) Index. décimale : PER Périodiques Résumé : Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n=964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain. En ligne : http://dx.doi.org/10.1186/2040-2392-5-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2279