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Détail de l'auteur
Auteur Keith A. YOUNG |
Documents disponibles écrits par cet auteur (1)
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Neuropathology and Animal Models of Autism: Genetic and Environmental Factors / Bharathi S. GADAD in Autism Research and Treatment, (October 2013)
[article]
Titre : Neuropathology and Animal Models of Autism: Genetic and Environmental Factors Type de document : Texte imprimé et/ou numérique Auteurs : Bharathi S. GADAD, Auteur ; Laura HEWITSON, Auteur ; Keith A. YOUNG, Auteur ; Dwight C. GERMAN, Auteur Année de publication : 2013 Article en page(s) : 12 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism is a heterogeneous behaviorally defined neurodevelopmental disorder. It is defined by the presence of marked social deficits, specific language abnormalities, and stereotyped repetitive patterns of behavior. Because of the variability in the behavioral phenotype of the disorder among patients, the term autism spectrum disorder has been established. In the first part of this review, we provide an overview of neuropathological findings from studies of autism postmortem brains and identify the cerebellum as one of the key brain regions that can play a role in the autism phenotype. We review research findings that indicate possible links between the environment and autism including the role of mercury and immune-related factors. Because both genes and environment can alter the structure of the developing brain in different ways, it is not surprising that there is heterogeneity in the behavioral and neuropathological phenotypes of autism spectrum disorders. Finally, we describe animal models of autism that occur following insertion of different autism-related genes and exposure to environmental factors, highlighting those models which exhibit both autism-like behavior and neuropathology. En ligne : http://dx.doi.org/10.1155/2013/731935 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228
in Autism Research and Treatment > (October 2013) . - 12 p.[article] Neuropathology and Animal Models of Autism: Genetic and Environmental Factors [Texte imprimé et/ou numérique] / Bharathi S. GADAD, Auteur ; Laura HEWITSON, Auteur ; Keith A. YOUNG, Auteur ; Dwight C. GERMAN, Auteur . - 2013 . - 12 p.
Langues : Anglais (eng)
in Autism Research and Treatment > (October 2013) . - 12 p.
Index. décimale : PER Périodiques Résumé : Autism is a heterogeneous behaviorally defined neurodevelopmental disorder. It is defined by the presence of marked social deficits, specific language abnormalities, and stereotyped repetitive patterns of behavior. Because of the variability in the behavioral phenotype of the disorder among patients, the term autism spectrum disorder has been established. In the first part of this review, we provide an overview of neuropathological findings from studies of autism postmortem brains and identify the cerebellum as one of the key brain regions that can play a role in the autism phenotype. We review research findings that indicate possible links between the environment and autism including the role of mercury and immune-related factors. Because both genes and environment can alter the structure of the developing brain in different ways, it is not surprising that there is heterogeneity in the behavioral and neuropathological phenotypes of autism spectrum disorders. Finally, we describe animal models of autism that occur following insertion of different autism-related genes and exposure to environmental factors, highlighting those models which exhibit both autism-like behavior and neuropathology. En ligne : http://dx.doi.org/10.1155/2013/731935 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228