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Détail de l'auteur
Auteur Lee THOMPSON |
Documents disponibles écrits par cet auteur (1)
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A Twin Study of Heritable and Shared Environmental Contributions to Autism / Thomas W. FRAZIER in Journal of Autism and Developmental Disorders, 44-8 (August 2014)
[article]
Titre : A Twin Study of Heritable and Shared Environmental Contributions to Autism Type de document : Texte imprimé et/ou numérique Auteurs : Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur Article en page(s) : p.2013-2025 Langues : Anglais (eng) Mots-clés : Autism Twins Genetic Heritability Environment Diagnosis Index. décimale : PER Périodiques Résumé : The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92?1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements. En ligne : http://dx.doi.org/10.1007/s10803-014-2081-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236
in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025[article] A Twin Study of Heritable and Shared Environmental Contributions to Autism [Texte imprimé et/ou numérique] / Thomas W. FRAZIER, Auteur ; Lee THOMPSON, Auteur ; Eric A. YOUNGSTROM, Auteur ; Paul LAW, Auteur ; Antonio Y. HARDAN, Auteur ; Charis ENG, Auteur ; Nathan MORRIS, Auteur . - p.2013-2025.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-8 (August 2014) . - p.2013-2025
Mots-clés : Autism Twins Genetic Heritability Environment Diagnosis Index. décimale : PER Périodiques Résumé : The present study examined genetic and shared environment contributions to quantitatively-measured autism symptoms and categorically-defined autism spectrum disorders (ASD). Participants included 568 twins from the Interactive Autism Network. Autism symptoms were obtained using the Social Communication Questionnaire and Social Responsiveness Scale. Categorically-defined ASD was based on clinical diagnoses. DeFries-Fulker and liability threshold models examined etiologic influences. Very high heritability was observed for extreme autism symptom levels ( h2g=.92?1.20 ). Extreme levels of social and repetitive behavior symptoms were strongly influenced by common genetic factors. Heritability of categorically-defined ASD diagnosis was comparatively low (.21, 95 % CI 0.15–0.28). High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements. En ligne : http://dx.doi.org/10.1007/s10803-014-2081-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236