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Auteur Nanda N. ROMMELSE |
Documents disponibles écrits par cet auteur (38)
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Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders / Jordan M. RAMSEY in Molecular Autism, (August 2013)
[article]
Titre : Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jordan M. RAMSEY, Auteur ; Paul C. GUEST, Auteur ; Jantine A.C. BROEK, Auteur ; Jeffrey GLENNON, Auteur ; Nanda N. ROMMELSE, Auteur ; Barbara FRANKE, Auteur ; Hassan RAHMOUNE, Auteur ; Jan K. BUITELAAR, Auteur ; Sabine BAHN, Auteur Année de publication : 2013 Article en page(s) : 18 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background
Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development.
Methods
We carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs.
Results
This analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling.
Conclusions
These deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders.En ligne : http://dx.doi.org/10.1186/2040-2392-4-27 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211
in Molecular Autism > (August 2013) . - 18 p.[article] Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders [Texte imprimé et/ou numérique] / Jordan M. RAMSEY, Auteur ; Paul C. GUEST, Auteur ; Jantine A.C. BROEK, Auteur ; Jeffrey GLENNON, Auteur ; Nanda N. ROMMELSE, Auteur ; Barbara FRANKE, Auteur ; Hassan RAHMOUNE, Auteur ; Jan K. BUITELAAR, Auteur ; Sabine BAHN, Auteur . - 2013 . - 18 p.
Langues : Anglais (eng)
in Molecular Autism > (August 2013) . - 18 p.
Index. décimale : PER Périodiques Résumé : Background
Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development.
Methods
We carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs.
Results
This analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling.
Conclusions
These deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders.En ligne : http://dx.doi.org/10.1186/2040-2392-4-27 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 Improved Diagnostic Validity of the ADOS Revised Algorithms: A Replication Study in an Independent Sample / Iris J. OOSTERLING in Journal of Autism and Developmental Disorders, 40-6 (June 2010)
[article]
Titre : Improved Diagnostic Validity of the ADOS Revised Algorithms: A Replication Study in an Independent Sample Type de document : Texte imprimé et/ou numérique Auteurs : Iris J. OOSTERLING, Auteur ; Sophie H. N. SWINKELS, Auteur ; Sascha ROOS, Auteur ; Janne C. VISSER, Auteur ; Maretha V. DE JONGE, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Annelies A. DE BILDT, Auteur ; Martijn LAPPENSCHAAR, Auteur Année de publication : 2010 Article en page(s) : p.689-703 Note générale : Article Open Access Langues : Anglais (eng) Mots-clés : Autism ADOS Algorithm Sensitivity Specificity Diagnosis Index. décimale : PER Périodiques Résumé : Recently, Gotham et al. (2007) proposed revised algorithms for the Autism Diagnostic Observation Schedule (ADOS) with improved diagnostic validity. The aim of the current study was to replicate predictive validity, factor structure, and correlations with age and verbal and nonverbal IQ of the ADOS revised algorithms for Modules 1 and 2 in a large independent Dutch sample (N = 532). Results showed that the improvement of diagnostic validity was most apparent for autism, except in very young or low functioning children. Results for other autism spectrum disorders were less consistent. Overall, these findings support the use of the more homogeneous revised algorithms, with the use of similar items across developmental cells making it easier to compare ADOS scores within and between individuals. En ligne : http://dx.doi.org/10.1007/s10803-009-0915-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102
in Journal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.689-703[article] Improved Diagnostic Validity of the ADOS Revised Algorithms: A Replication Study in an Independent Sample [Texte imprimé et/ou numérique] / Iris J. OOSTERLING, Auteur ; Sophie H. N. SWINKELS, Auteur ; Sascha ROOS, Auteur ; Janne C. VISSER, Auteur ; Maretha V. DE JONGE, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Annelies A. DE BILDT, Auteur ; Martijn LAPPENSCHAAR, Auteur . - 2010 . - p.689-703.
Article Open Access
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.689-703
Mots-clés : Autism ADOS Algorithm Sensitivity Specificity Diagnosis Index. décimale : PER Périodiques Résumé : Recently, Gotham et al. (2007) proposed revised algorithms for the Autism Diagnostic Observation Schedule (ADOS) with improved diagnostic validity. The aim of the current study was to replicate predictive validity, factor structure, and correlations with age and verbal and nonverbal IQ of the ADOS revised algorithms for Modules 1 and 2 in a large independent Dutch sample (N = 532). Results showed that the improvement of diagnostic validity was most apparent for autism, except in very young or low functioning children. Results for other autism spectrum disorders were less consistent. Overall, these findings support the use of the more homogeneous revised algorithms, with the use of similar items across developmental cells making it easier to compare ADOS scores within and between individuals. En ligne : http://dx.doi.org/10.1007/s10803-009-0915-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 Lack of replication of previous autism spectrum disorder GWAS hits in European populations / Bàrbara TORRICO in Autism Research, 10-2 (February 2017)
[article]
Titre : Lack of replication of previous autism spectrum disorder GWAS hits in European populations Type de document : Texte imprimé et/ou numérique Auteurs : Bàrbara TORRICO, Auteur ; Andreas G. CHIOCCHETTI, Auteur ; Elena BACCHELLI, Auteur ; Elisabetta TRABETTI, Auteur ; Amaia HERVAS, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur ; Afsheen YOUSAF, Auteur ; Eftichia DUKETIS, Auteur ; Christine M. FREITAG, Auteur ; Rafaela CABALLERO-ANDALUZ, Auteur ; Amalia MARTINEZ-MIR, Auteur ; Francisco G. SCHOLL, Auteur ; Marta RIBASES, Auteur ; ITAN, Auteur ; Agatino BATTAGLIA, Auteur ; Giovanni MALERBA, Auteur ; Richard DELORME, Auteur ; Marion BENABOU, Auteur ; Elena MAESTRINI, Auteur ; Thomas BOURGERON, Auteur ; Bru CORMAND, Auteur ; Claudio TOMA, Auteur Article en page(s) : p.202-211 Langues : Anglais (eng) Mots-clés : genome-wide association study replication autism spectrum disorder European populations MACROD2 SEMA5A MSNP1 Index. décimale : PER Périodiques Résumé : Common variants contribute significantly to the genetics of autism spectrum disorder (ASD), although the identification of individual risk polymorphisms remains still elusive due to their small effect sizes and limited sample sizes available for association studies. During the last decade several genome-wide association studies (GWAS) have enabled the detection of a few plausible risk variants. The three main studies are family-based and pointed at SEMA5A (rs10513025), MACROD2 (rs4141463) and MSNP1 (rs4307059). In our study we attempted to replicate these GWAS hits using a case-control association study in five European populations of ASD patients and gender-matched controls, all Caucasians. Results showed no association of individual variants with ASD in any of the population groups considered or in the combined European sample. We performed a meta-analysis study across five European populations for rs10513025 (1,904 ASD cases and 2,674 controls), seven European populations for rs4141463 (2,855 ASD cases and 36,177 controls) and five European populations for rs4307059 (2,347 ASD cases and 2,764 controls). The results showed an odds ratio (OR) of 1.05 (95% CI?=?0.84–1.32) for rs10513025, 1.0002 (95% CI?=?0.93–1.08) for rs4141463 and 1.01 (95% CI?=?0.92–1.1) for rs4307059, with no significant P-values (rs10513025, P?=?0.73; rs4141463, P?=?0.95; rs4307059, P?=?0.9). No association was found when we considered either only high functioning autism (HFA), genders separately or only multiplex families. Ongoing GWAS projects with larger ASD cohorts will contribute to clarify the role of common variation in the disorder and will likely identify risk variants of modest effect not detected previously. En ligne : http://dx.doi.org/10.1002/aur.1662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303
in Autism Research > 10-2 (February 2017) . - p.202-211[article] Lack of replication of previous autism spectrum disorder GWAS hits in European populations [Texte imprimé et/ou numérique] / Bàrbara TORRICO, Auteur ; Andreas G. CHIOCCHETTI, Auteur ; Elena BACCHELLI, Auteur ; Elisabetta TRABETTI, Auteur ; Amaia HERVAS, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur ; Afsheen YOUSAF, Auteur ; Eftichia DUKETIS, Auteur ; Christine M. FREITAG, Auteur ; Rafaela CABALLERO-ANDALUZ, Auteur ; Amalia MARTINEZ-MIR, Auteur ; Francisco G. SCHOLL, Auteur ; Marta RIBASES, Auteur ; ITAN, Auteur ; Agatino BATTAGLIA, Auteur ; Giovanni MALERBA, Auteur ; Richard DELORME, Auteur ; Marion BENABOU, Auteur ; Elena MAESTRINI, Auteur ; Thomas BOURGERON, Auteur ; Bru CORMAND, Auteur ; Claudio TOMA, Auteur . - p.202-211.
Langues : Anglais (eng)
in Autism Research > 10-2 (February 2017) . - p.202-211
Mots-clés : genome-wide association study replication autism spectrum disorder European populations MACROD2 SEMA5A MSNP1 Index. décimale : PER Périodiques Résumé : Common variants contribute significantly to the genetics of autism spectrum disorder (ASD), although the identification of individual risk polymorphisms remains still elusive due to their small effect sizes and limited sample sizes available for association studies. During the last decade several genome-wide association studies (GWAS) have enabled the detection of a few plausible risk variants. The three main studies are family-based and pointed at SEMA5A (rs10513025), MACROD2 (rs4141463) and MSNP1 (rs4307059). In our study we attempted to replicate these GWAS hits using a case-control association study in five European populations of ASD patients and gender-matched controls, all Caucasians. Results showed no association of individual variants with ASD in any of the population groups considered or in the combined European sample. We performed a meta-analysis study across five European populations for rs10513025 (1,904 ASD cases and 2,674 controls), seven European populations for rs4141463 (2,855 ASD cases and 36,177 controls) and five European populations for rs4307059 (2,347 ASD cases and 2,764 controls). The results showed an odds ratio (OR) of 1.05 (95% CI?=?0.84–1.32) for rs10513025, 1.0002 (95% CI?=?0.93–1.08) for rs4141463 and 1.01 (95% CI?=?0.92–1.1) for rs4307059, with no significant P-values (rs10513025, P?=?0.73; rs4141463, P?=?0.95; rs4307059, P?=?0.9). No association was found when we considered either only high functioning autism (HFA), genders separately or only multiplex families. Ongoing GWAS projects with larger ASD cohorts will contribute to clarify the role of common variation in the disorder and will likely identify risk variants of modest effect not detected previously. En ligne : http://dx.doi.org/10.1002/aur.1662 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 Match or Mismatch? Influence of Parental and Offspring ASD and ADHD Symptoms on the Parent–Child Relationship / Daphne J. STEIJN in Journal of Autism and Developmental Disorders, 43-8 (August 2013)
[article]
Titre : Match or Mismatch? Influence of Parental and Offspring ASD and ADHD Symptoms on the Parent–Child Relationship Type de document : Texte imprimé et/ou numérique Auteurs : Daphne J. STEIJN, Auteur ; Anoek M. OERLEMANS, Auteur ; Marcel A. G. AKEN, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Article en page(s) : p.1935-1945 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Attention-deficit/hyperactivity disorder Parental symptoms Parent–child relationship Index. décimale : PER Périodiques Résumé : Few studies have examined the influence of parental ASD and ADHD symptoms in combination with child pathology on the parent- child relationship as perceived by the child. A sample of 132 families was recruited with one child with ASD (with/without ADHD), and one unaffected sibling. Affected children (regardless of diagnosis) reported lower acceptance and conflict resolution scores than their unaffected siblings, with conflict resolution scores (but not acceptance) being lower than the norm according to both affected and unaffected children in both fathers and mothers. Higher paternal, but not maternal, ASD and ADHD symptoms were related to poorer scores regarding acceptance and conflict resolution, respectively. Treatment targeting conflict resolution skills of parents and the feeling of being less accepted in children with ASD/ADHD may be beneficial. En ligne : http://dx.doi.org/10.1007/s10803-012-1746-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1935-1945[article] Match or Mismatch? Influence of Parental and Offspring ASD and ADHD Symptoms on the Parent–Child Relationship [Texte imprimé et/ou numérique] / Daphne J. STEIJN, Auteur ; Anoek M. OERLEMANS, Auteur ; Marcel A. G. AKEN, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - p.1935-1945.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1935-1945
Mots-clés : Autism spectrum disorder Attention-deficit/hyperactivity disorder Parental symptoms Parent–child relationship Index. décimale : PER Périodiques Résumé : Few studies have examined the influence of parental ASD and ADHD symptoms in combination with child pathology on the parent- child relationship as perceived by the child. A sample of 132 families was recruited with one child with ASD (with/without ADHD), and one unaffected sibling. Affected children (regardless of diagnosis) reported lower acceptance and conflict resolution scores than their unaffected siblings, with conflict resolution scores (but not acceptance) being lower than the norm according to both affected and unaffected children in both fathers and mothers. Higher paternal, but not maternal, ASD and ADHD symptoms were related to poorer scores regarding acceptance and conflict resolution, respectively. Treatment targeting conflict resolution skills of parents and the feeling of being less accepted in children with ASD/ADHD may be beneficial. En ligne : http://dx.doi.org/10.1007/s10803-012-1746-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=206 Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand / Nanda N. ROMMELSE in Journal of Child Psychology and Psychiatry, 48-11 (November 2007)
[article]
Titre : Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand Type de document : Texte imprimé et/ou numérique Auteurs : Nanda N. ROMMELSE, Auteur ; Joseph A. SERGEANT, Auteur ; Leo M. J. DE SONNEVILLE, Auteur ; Jan K. BUITELAAR, Auteur ; Jaap OOSTERLAAN, Auteur ; Marieke E. ALTINK, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur Année de publication : 2007 Article en page(s) : p.1071–1079 Langues : Anglais (eng) Mots-clés : ADHD non-affected-sibling motor-control endophenotype Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is strongly influenced by heritability. Identifying heritable vulnerability traits (endophenotypes) that mark a relatively high risk of developing the disorder can contribute to the identification of risk genes. A fruitful area for the search for such endophenotypes may be motor control in children with ADHD, since the disorder is frequently accompanied by motor problems.
Method: The current study used a large sample of 350 children with ADHD, 195 non-affected siblings and 271 normal controls aged 5–19 years. Children were administered two computerised motor control tasks in which they had to trace a path between two circles (Tracking task) and follow a randomly moving target (Pursuit task). Both tasks were performed with both the right and the left hand.
Results: Children with ADHD were less precise and stable than controls. Non-affected siblings also deviated from controls, but only on the Tracking task. Group differences were modulated by the use of the right versus the left hand: no group differences emerged when the right hand was used, yet group differences did emerge when the left hand was used. Performance on both tasks was significantly familial.
Conclusions: Imprecision and instability of movements in children with ADHD and in their non-affected siblings as measured by the Tracking task might be suitable endophenotypic candidates: these deficits are familially present in children having ADHD as well as in their non-affected siblings. Motor performance might be best assessed in children using their left hand, because motor control deficits are most pronounced using the left hand. This might relate to right hemispheric brain pathology in children with ADHD (and possibly in their non-affected siblings) that is related to the control of the left hand and/or relate to differential effects of daily life practice on both hands, which may be smaller on the left hand.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01781.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Journal of Child Psychology and Psychiatry > 48-11 (November 2007) . - p.1071–1079[article] Motor control in children with ADHD and non-affected siblings: deficits most pronounced using the left hand [Texte imprimé et/ou numérique] / Nanda N. ROMMELSE, Auteur ; Joseph A. SERGEANT, Auteur ; Leo M. J. DE SONNEVILLE, Auteur ; Jan K. BUITELAAR, Auteur ; Jaap OOSTERLAAN, Auteur ; Marieke E. ALTINK, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur . - 2007 . - p.1071–1079.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 48-11 (November 2007) . - p.1071–1079
Mots-clés : ADHD non-affected-sibling motor-control endophenotype Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is strongly influenced by heritability. Identifying heritable vulnerability traits (endophenotypes) that mark a relatively high risk of developing the disorder can contribute to the identification of risk genes. A fruitful area for the search for such endophenotypes may be motor control in children with ADHD, since the disorder is frequently accompanied by motor problems.
Method: The current study used a large sample of 350 children with ADHD, 195 non-affected siblings and 271 normal controls aged 5–19 years. Children were administered two computerised motor control tasks in which they had to trace a path between two circles (Tracking task) and follow a randomly moving target (Pursuit task). Both tasks were performed with both the right and the left hand.
Results: Children with ADHD were less precise and stable than controls. Non-affected siblings also deviated from controls, but only on the Tracking task. Group differences were modulated by the use of the right versus the left hand: no group differences emerged when the right hand was used, yet group differences did emerge when the left hand was used. Performance on both tasks was significantly familial.
Conclusions: Imprecision and instability of movements in children with ADHD and in their non-affected siblings as measured by the Tracking task might be suitable endophenotypic candidates: these deficits are familially present in children having ADHD as well as in their non-affected siblings. Motor performance might be best assessed in children using their left hand, because motor control deficits are most pronounced using the left hand. This might relate to right hemispheric brain pathology in children with ADHD (and possibly in their non-affected siblings) that is related to the control of the left hand and/or relate to differential effects of daily life practice on both hands, which may be smaller on the left hand.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01781.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Narrowly Versus Broadly Defined Autism Spectrum Disorders: Differences in Pre- and Perinatal Risk Factors / Janne C. VISSER in Journal of Autism and Developmental Disorders, 43-7 (July 2013)
PermalinkNeurocognitive markers of late-onset ADHD: a 6-year longitudinal study / Shahrzad ILBEGI in Journal of Child Psychology and Psychiatry, 62-2 (February 2021)
PermalinkNeurocognitive predictors of substance use disorders and nicotine dependence in ADHD probands, their unaffected siblings, and controls: a 4-year prospective follow-up / Annabeth P. GROENMAN in Journal of Child Psychology and Psychiatry, 56-5 (May 2015)
PermalinkPerinatal risk factors interacting with catechol O-methyltransferase and the serotonin transporter gene predict ASD symptoms in children with ADHD / Judith NIJMEIJER in Journal of Child Psychology and Psychiatry, 51-11 (November 2010)
PermalinkA Pilot Study of Abnormal Growth in Autism Spectrum Disorders and Other Childhood Psychiatric Disorders / Nanda N. ROMMELSE in Journal of Autism and Developmental Disorders, 41-1 (January 2011)
PermalinkQuantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 / Judith S. NIJMEIJER in Journal of Autism and Developmental Disorders, 44-7 (July 2014)
PermalinkRandomized Controlled Trial of the Focus Parent Training for Toddlers with Autism: 1-Year Outcome / Iris J. OOSTERLING in Journal of Autism and Developmental Disorders, 40-12 (December 2010)
PermalinkSimplex and Multiplex Stratification in ASD and ADHD Families: A Promising Approach for Identifying Overlapping and Unique Underpinnings of ASD and ADHD? / Anoek M. OERLEMANS in Journal of Autism and Developmental Disorders, 45-3 (March 2015)
PermalinkSubstance use and nicotine dependence in persistent, remittent, and late-onset ADHD: a 10-year longitudinal study from childhood to young adulthood / S. ILBEGI in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)
PermalinkSustainability of an early detection program for autism spectrum disorder over the course of 8 years / M. K. PIJL in Autism, 22-8 (November 2018)
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