Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Gordon CHENG |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Atypical modulation of hypothalamic activity by social context in ASD / Thierry CHAMINADE in Research in Autism Spectrum Disorders, 10 (February 2015)
[article]
Titre : Atypical modulation of hypothalamic activity by social context in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Thierry CHAMINADE, Auteur ; David DA FONSECA, Auteur ; Delphine ROSSET, Auteur ; Gordon CHENG, Auteur ; Christine DERUELLE, Auteur Article en page(s) : p.41-50 Langues : Anglais (eng) Mots-clés : Autism Social interaction Mentalization Social motivation Hypothalamus Index. décimale : PER Périodiques Résumé : High-functioning individuals with Autism Spectrum Disorder (ASD) and age- and verbal IQ-matched controls (CTL) were fMRI scanned when playing “stone paper scissors”. They believed they were playing against three different opponents: a Human, a Robot endowed with an artificial intelligence attempting to win the game, and a Computer running a random number generator. No differences between ASD and CTL reached significance in canonical mentalizing regions, in the medial prefrontal cortex and right temporoparietal junction. In contrast, activity in a cluster located in the left hypothalamus, attributed to the paraventricular hypothalamic nucleus (PHN), increased in the CTL, but not ASD, group when participants played against the human compared to the artificial agent. The left temporoparietal junction (lTPJ), that has been previously associated with anthropomorphization, influenced this PHN cluster activity differently between groups, with a significantly negative functional connectivity when CTL played against the robot and when ASD participants played against the human. Brain activity results are consistent with the hypothesis that hypothalamus-secreted neurohormones, including oxytocin, could support motivation for social interactions and be impaired in autism. Brain connectivity results suggest that cortical encoding of social context information, putatively related to anthropomorphism, has a reversed effect on hypothalamus activity in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260
in Research in Autism Spectrum Disorders > 10 (February 2015) . - p.41-50[article] Atypical modulation of hypothalamic activity by social context in ASD [Texte imprimé et/ou numérique] / Thierry CHAMINADE, Auteur ; David DA FONSECA, Auteur ; Delphine ROSSET, Auteur ; Gordon CHENG, Auteur ; Christine DERUELLE, Auteur . - p.41-50.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 10 (February 2015) . - p.41-50
Mots-clés : Autism Social interaction Mentalization Social motivation Hypothalamus Index. décimale : PER Périodiques Résumé : High-functioning individuals with Autism Spectrum Disorder (ASD) and age- and verbal IQ-matched controls (CTL) were fMRI scanned when playing “stone paper scissors”. They believed they were playing against three different opponents: a Human, a Robot endowed with an artificial intelligence attempting to win the game, and a Computer running a random number generator. No differences between ASD and CTL reached significance in canonical mentalizing regions, in the medial prefrontal cortex and right temporoparietal junction. In contrast, activity in a cluster located in the left hypothalamus, attributed to the paraventricular hypothalamic nucleus (PHN), increased in the CTL, but not ASD, group when participants played against the human compared to the artificial agent. The left temporoparietal junction (lTPJ), that has been previously associated with anthropomorphization, influenced this PHN cluster activity differently between groups, with a significantly negative functional connectivity when CTL played against the robot and when ASD participants played against the human. Brain activity results are consistent with the hypothesis that hypothalamus-secreted neurohormones, including oxytocin, could support motivation for social interactions and be impaired in autism. Brain connectivity results suggest that cortical encoding of social context information, putatively related to anthropomorphism, has a reversed effect on hypothalamus activity in autism. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.015 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260