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Auteur Diego BARONIO |
Documents disponibles écrits par cet auteur (2)
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Effect of a ketogenic diet on autism spectrum disorder: A systematic review / Kamila CASTRO in Research in Autism Spectrum Disorders, 20 (December 2015)
[article]
Titre : Effect of a ketogenic diet on autism spectrum disorder: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : Kamila CASTRO, Auteur ; Larissa Slongo FACCIOLI, Auteur ; Diego BARONIO, Auteur ; Carmem GOTTFRIED, Auteur ; Ingrid Schweigert PERRY, Auteur ; Rudimar DOS SANTOS RIESGO, Auteur Article en page(s) : p.31-38 Langues : Anglais (eng) Mots-clés : Autistic disorder Ketogenic diet Behavioural symptoms Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is primarily characterized by impaired social interaction and communication, as well as restricted repetitive behaviours and interests. The utilization of the ketogenic diet (KD) in different neurological disorders has become a valid approach over time, and recently, it has also been advocated as a potential therapeutic for ASD. A MEDLINE, Scopus and Cochrane search was performed by two independent reviewers to investigate the relationship between ASD and the KD in humans and experimental studies. Of the eighty-one potentially relevant articles, eight articles met the inclusion criteria: three studies with animals and five studies with humans. The consistency between reviewers was ? = 0.817. In humans, the studies mainly focused on the behavioural outcomes provided by this diet and reported ameliorated behavioural symptoms via an improved score in the Childhood Autism Rating Scale (CARS). The KD in prenatal valproic acid (VPA)-exposed rodents, as well as in BTBR and Mecp2 mice strains, resulted in an attenuation of some autistic-like features. The limited number of reports of improvements after treatment with the KD is insufficient to attest to the practicability of the KD as a treatment for ASD, but it is still a good indicator that this diet is a promising therapeutic option for this disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270
in Research in Autism Spectrum Disorders > 20 (December 2015) . - p.31-38[article] Effect of a ketogenic diet on autism spectrum disorder: A systematic review [Texte imprimé et/ou numérique] / Kamila CASTRO, Auteur ; Larissa Slongo FACCIOLI, Auteur ; Diego BARONIO, Auteur ; Carmem GOTTFRIED, Auteur ; Ingrid Schweigert PERRY, Auteur ; Rudimar DOS SANTOS RIESGO, Auteur . - p.31-38.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 20 (December 2015) . - p.31-38
Mots-clés : Autistic disorder Ketogenic diet Behavioural symptoms Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is primarily characterized by impaired social interaction and communication, as well as restricted repetitive behaviours and interests. The utilization of the ketogenic diet (KD) in different neurological disorders has become a valid approach over time, and recently, it has also been advocated as a potential therapeutic for ASD. A MEDLINE, Scopus and Cochrane search was performed by two independent reviewers to investigate the relationship between ASD and the KD in humans and experimental studies. Of the eighty-one potentially relevant articles, eight articles met the inclusion criteria: three studies with animals and five studies with humans. The consistency between reviewers was ? = 0.817. In humans, the studies mainly focused on the behavioural outcomes provided by this diet and reported ameliorated behavioural symptoms via an improved score in the Childhood Autism Rating Scale (CARS). The KD in prenatal valproic acid (VPA)-exposed rodents, as well as in BTBR and Mecp2 mice strains, resulted in an attenuation of some autistic-like features. The limited number of reports of improvements after treatment with the KD is insufficient to attest to the practicability of the KD as a treatment for ASD, but it is still a good indicator that this diet is a promising therapeutic option for this disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 Zebrafish embryonically exposed to valproic acid present impaired retinal development and sleep behavior / Laura DEOLIVEIRA-MELLO in Autism Research, 16-10 (October 2023)
[article]
Titre : Zebrafish embryonically exposed to valproic acid present impaired retinal development and sleep behavior Type de document : Texte imprimé et/ou numérique Auteurs : Laura DEOLIVEIRA-MELLO, Auteur ; Diego BARONIO, Auteur ; Pertti PANULA, Auteur Article en page(s) : p.1877-1890 Index. décimale : PER Périodiques Résumé : Abstract Prenatal exposure to valproic acid (VPA), a drug widely used to treat epilepsy and bipolar disorder, is an environmental risk factor for autism spectrum disorder (ASD). VPA has been used to reproduce the core symptoms of ASD in animal model organisms, including zebrafish. Visual system functioning is essential in the interpretation of social conditions and plays an important role of several behavioral responses. We hypothesized that behavioral deficits displayed by ASD patients may involve impaired visual processing. We used zebrafish as model organism to investigate the visual system after embryonic exposure to VPA using histological, behavioral and gene expression analysis. We analyzed the pineal gland of zebrafish and sleep-like behavior to study how VPA exposure alters photo-sensibility of zebrafish. VPA-exposed zebrafish showed a delay in the development of the retina and optic nerve, which normalized at five days post fertilization. At larval stage, VPA-exposed zebrafish showed sleep disturbances associated with a reduced number of serotonin-producing cells of the pineal gland. In addition, the number of hypocretin/orexin (hcrt) expressing neurons in the rostral hypothalamus at 6 and 14?days post fertilization was reduced. In conclusion, we demonstrated that although VPA exposure leads to a delay in visual system development, it does not affect larval visual function. The novel finding that VPA alters significantly cells involved in sleep regulation and the sleep-like state itself may be relevant for understanding sleep disturbances in ASD patients. En ligne : https://doi.org/10.1002/aur.3010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Autism Research > 16-10 (October 2023) . - p.1877-1890[article] Zebrafish embryonically exposed to valproic acid present impaired retinal development and sleep behavior [Texte imprimé et/ou numérique] / Laura DEOLIVEIRA-MELLO, Auteur ; Diego BARONIO, Auteur ; Pertti PANULA, Auteur . - p.1877-1890.
in Autism Research > 16-10 (October 2023) . - p.1877-1890
Index. décimale : PER Périodiques Résumé : Abstract Prenatal exposure to valproic acid (VPA), a drug widely used to treat epilepsy and bipolar disorder, is an environmental risk factor for autism spectrum disorder (ASD). VPA has been used to reproduce the core symptoms of ASD in animal model organisms, including zebrafish. Visual system functioning is essential in the interpretation of social conditions and plays an important role of several behavioral responses. We hypothesized that behavioral deficits displayed by ASD patients may involve impaired visual processing. We used zebrafish as model organism to investigate the visual system after embryonic exposure to VPA using histological, behavioral and gene expression analysis. We analyzed the pineal gland of zebrafish and sleep-like behavior to study how VPA exposure alters photo-sensibility of zebrafish. VPA-exposed zebrafish showed a delay in the development of the retina and optic nerve, which normalized at five days post fertilization. At larval stage, VPA-exposed zebrafish showed sleep disturbances associated with a reduced number of serotonin-producing cells of the pineal gland. In addition, the number of hypocretin/orexin (hcrt) expressing neurons in the rostral hypothalamus at 6 and 14?days post fertilization was reduced. In conclusion, we demonstrated that although VPA exposure leads to a delay in visual system development, it does not affect larval visual function. The novel finding that VPA alters significantly cells involved in sleep regulation and the sleep-like state itself may be relevant for understanding sleep disturbances in ASD patients. En ligne : https://doi.org/10.1002/aur.3010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513