Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Sanbing SHEN |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Molecular Pathways in Autistic Spectrum Disorders / Louise GALLAGHER in Key Issues in Mental Health, 180 (2015)
[article]
Titre : Molecular Pathways in Autistic Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Louise GALLAGHER, Auteur ; Sanbing SHEN, Auteur ; Ric ANNEY, Auteur Article en page(s) : p.97-112 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : Major advances in neuroscience have highlighted previously elusive molecular pathways for autistic spectrum disorders (ASD) which are essential to the identification of molecular targets for drug discovery. The evidence of the heritability of ASD is now well established, and the last decade brought an exponential rate of discovery in ASD genetics. In particular rare chromosomal structural rearrangements and rare sequence variants have been implicated, with common genetic variation conferring a modest risk. Rare genetic mutations of major effect offer direct targets for the study of underlying molecular mechanisms. Systems biology approaches such as data mining of large genetic data sets in ASD are also used to identify related functional pathways. A greater understanding of the neural mechanisms underpinning ASD is required to determine disrupted developmental processes and how and when pharmacological and behavioural interventions are best initiated. Identification of the disease mechanisms associated with monogenetic neurodevelopmental disorders such as Rett syndrome and fragile X syndrome have led to new molecular targets and potential treatments which have provided optimism for researchers and the ASD community. Taken together, rare and common genetic variations in ASD implicate critical pathways involving chromatin remodelling, synaptogenesis, synapse specialization and intracellular signalling mechanisms. The following chapter will synthesize evidence from a range of sources to illustrate the molecular pathways that appear to be most implicated in ASD, providing potential targets for new drug exploitation. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271
in Key Issues in Mental Health > 180 (2015) . - p.97-112[article] Molecular Pathways in Autistic Spectrum Disorders [Texte imprimé et/ou numérique] / Louise GALLAGHER, Auteur ; Sanbing SHEN, Auteur ; Ric ANNEY, Auteur . - p.97-112.
Langues : Anglais (eng)
in Key Issues in Mental Health > 180 (2015) . - p.97-112
Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : Major advances in neuroscience have highlighted previously elusive molecular pathways for autistic spectrum disorders (ASD) which are essential to the identification of molecular targets for drug discovery. The evidence of the heritability of ASD is now well established, and the last decade brought an exponential rate of discovery in ASD genetics. In particular rare chromosomal structural rearrangements and rare sequence variants have been implicated, with common genetic variation conferring a modest risk. Rare genetic mutations of major effect offer direct targets for the study of underlying molecular mechanisms. Systems biology approaches such as data mining of large genetic data sets in ASD are also used to identify related functional pathways. A greater understanding of the neural mechanisms underpinning ASD is required to determine disrupted developmental processes and how and when pharmacological and behavioural interventions are best initiated. Identification of the disease mechanisms associated with monogenetic neurodevelopmental disorders such as Rett syndrome and fragile X syndrome have led to new molecular targets and potential treatments which have provided optimism for researchers and the ASD community. Taken together, rare and common genetic variations in ASD implicate critical pathways involving chromatin remodelling, synaptogenesis, synapse specialization and intracellular signalling mechanisms. The following chapter will synthesize evidence from a range of sources to illustrate the molecular pathways that appear to be most implicated in ASD, providing potential targets for new drug exploitation. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=271