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Auteur Bartholomew D. BRIGIDI |
Documents disponibles écrits par cet auteur (2)
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Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment / M. I. GERIN in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)
[article]
Titre : Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment Type de document : Texte imprimé et/ou numérique Auteurs : M. I. GERIN, Auteur ; E. VIDING, Auteur ; J. B. PINGAULT, Auteur ; V. B. PUETZ, Auteur ; A. R. KNODT, Auteur ; S. R. RADTKE, Auteur ; Bartholomew D. BRIGIDI, Auteur ; J. R. SWARTZ, Auteur ; A. R. HARIRI, Auteur ; E. J. MCCRORY, Auteur Article en page(s) : p.752-761 Langues : Anglais (eng) Mots-clés : Maltreatment amygdala child abuse internalizing disorder stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood maltreatment is one of the most potent predictors of future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in the pathogenesis and maintenance of internalizing disorders among individuals with a history of childhood maltreatment. METHODS: Using data from a sample of 1,144 young adults, we investigated the contribution of baseline threat-related amygdala reactivity and prospective major stressful life events to internalizing symptoms severity 1 year later (on average) in individuals with a history of maltreatment (n = 100) and propensity score matched nonmaltreated peers (n = 96). RESULTS: Even after stringently matching for several potentially confounding variables - including baseline internalizing symptoms, socioeconomic status and IQ - childhood maltreatment status predicted increased amygdala reactivity at baseline, elevated post-baseline exposure to major stressful life events and internalizing symptoms at follow-up. We also showed, for the first time, that amygdala reactivity at baseline and also post-baseline exposure to major stressful life events mediated the association between a history of maltreatment and future internalizing symptoms. CONCLUSIONS: These findings provide support for the view that maltreatment is a potent developmental insult leading to long-lasting neurocognitive recalibrations of the threat processing system. It is possible that such alterations, over time, may impact mental health functioning by compromising the ability to effectively negotiate everyday challenges (stress susceptibility). These alterations were not, however, found to sensitize an individual to the impact of major stressful life events. The results of this study also lend compelling support to the view that increased psychiatric risk, in the context of childhood maltreatment, follows from an increased propensity to experience major stressful life events (stress generation). En ligne : http://dx.doi.org/10.1111/jcpp.13041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.752-761[article] Heightened amygdala reactivity and increased stress generation predict internalizing symptoms in adults following childhood maltreatment [Texte imprimé et/ou numérique] / M. I. GERIN, Auteur ; E. VIDING, Auteur ; J. B. PINGAULT, Auteur ; V. B. PUETZ, Auteur ; A. R. KNODT, Auteur ; S. R. RADTKE, Auteur ; Bartholomew D. BRIGIDI, Auteur ; J. R. SWARTZ, Auteur ; A. R. HARIRI, Auteur ; E. J. MCCRORY, Auteur . - p.752-761.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.752-761
Mots-clés : Maltreatment amygdala child abuse internalizing disorder stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood maltreatment is one of the most potent predictors of future psychopathology, including internalizing disorders. It remains unclear whether heightened amygdala reactivity to threat and elevated stress exposure may be implicated in the pathogenesis and maintenance of internalizing disorders among individuals with a history of childhood maltreatment. METHODS: Using data from a sample of 1,144 young adults, we investigated the contribution of baseline threat-related amygdala reactivity and prospective major stressful life events to internalizing symptoms severity 1 year later (on average) in individuals with a history of maltreatment (n = 100) and propensity score matched nonmaltreated peers (n = 96). RESULTS: Even after stringently matching for several potentially confounding variables - including baseline internalizing symptoms, socioeconomic status and IQ - childhood maltreatment status predicted increased amygdala reactivity at baseline, elevated post-baseline exposure to major stressful life events and internalizing symptoms at follow-up. We also showed, for the first time, that amygdala reactivity at baseline and also post-baseline exposure to major stressful life events mediated the association between a history of maltreatment and future internalizing symptoms. CONCLUSIONS: These findings provide support for the view that maltreatment is a potent developmental insult leading to long-lasting neurocognitive recalibrations of the threat processing system. It is possible that such alterations, over time, may impact mental health functioning by compromising the ability to effectively negotiate everyday challenges (stress susceptibility). These alterations were not, however, found to sensitize an individual to the impact of major stressful life events. The results of this study also lend compelling support to the view that increased psychiatric risk, in the context of childhood maltreatment, follows from an increased propensity to experience major stressful life events (stress generation). En ligne : http://dx.doi.org/10.1111/jcpp.13041 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress / Jamie L. HANSON in Development and Psychopathology, 27-4 (Part 2) (November 2015)
[article]
Titre : Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress Type de document : Texte imprimé et/ou numérique Auteurs : Jamie L. HANSON, Auteur ; Annchen R. KNODT, Auteur ; Bartholomew D. BRIGIDI, Auteur ; Ahmad R. HARIRI, Auteur Article en page(s) : p.1611-1619 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The experience of child maltreatment is a significant risk factor for the development of later internalizing disorders such as depression and anxiety. This risk is particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists for such “stress sensitization,” little is known about the mechanisms mediating such relationships, particularly within the brain. Here we report that the experience of child maltreatment independent of recent life stress, gender, and age is associated with reduced structural integrity of the uncinate fasciculus, a major white matter pathway between the amygdala and ventromedial prefrontal cortex, in young adults. We further demonstrate that individuals with lower uncinate fasciculus integrity at baseline who subsequently experience stressful life events report higher levels of internalizing symptomatology at follow-up. Our findings suggest a novel neurobiological mechanism linking child maltreatment with later internalizing symptoms, specifically altered structural connectivity within the brain's threat-detection and emotion-regulation circuitry. En ligne : http://dx.doi.org/10.1017/S0954579415000978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273
in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1611-1619[article] Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress [Texte imprimé et/ou numérique] / Jamie L. HANSON, Auteur ; Annchen R. KNODT, Auteur ; Bartholomew D. BRIGIDI, Auteur ; Ahmad R. HARIRI, Auteur . - p.1611-1619.
Langues : Anglais (eng)
in Development and Psychopathology > 27-4 (Part 2) (November 2015) . - p.1611-1619
Index. décimale : PER Périodiques Résumé : The experience of child maltreatment is a significant risk factor for the development of later internalizing disorders such as depression and anxiety. This risk is particularly heightened after exposure to additional, more contemporaneous stress. While behavioral evidence exists for such “stress sensitization,” little is known about the mechanisms mediating such relationships, particularly within the brain. Here we report that the experience of child maltreatment independent of recent life stress, gender, and age is associated with reduced structural integrity of the uncinate fasciculus, a major white matter pathway between the amygdala and ventromedial prefrontal cortex, in young adults. We further demonstrate that individuals with lower uncinate fasciculus integrity at baseline who subsequently experience stressful life events report higher levels of internalizing symptomatology at follow-up. Our findings suggest a novel neurobiological mechanism linking child maltreatment with later internalizing symptoms, specifically altered structural connectivity within the brain's threat-detection and emotion-regulation circuitry. En ligne : http://dx.doi.org/10.1017/S0954579415000978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=273