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Auteur William S. OETTING |
Documents disponibles écrits par cet auteur (1)
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Mendelian randomization: A novel test of the gateway hypothesis and models of gene–environment interplay / Daniel E. IRONS in Development and Psychopathology, 19-4 (Fall 2007)
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Titre : Mendelian randomization: A novel test of the gateway hypothesis and models of gene–environment interplay Type de document : Texte imprimé et/ou numérique Auteurs : Daniel E. IRONS, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur ; William S. OETTING, Auteur Année de publication : 2007 Article en page(s) : p.1181-1195 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : To determine if drinking behavior in adolescence provides a “gateway” leading to the misuse of other psychoactive substances and antisocial behavior, we genotyped 180 Asian adolescent adoptees to determine if they inherited the deficient from of the aldehyde dehydrogenase 2 (ALDH2) enzyme that is important in the metabolism of alcohol. Based on the gateway model, we hypothesized that those with normal enzyme activity (70% of the sample) who began to misuse alcohol would also misuse other drugs and display antisocial tendencies. Those with the enzyme deficiency (30%), because they experience unpleasant side effects associated with drinking, were expected to show less evidence of alcohol misuse and thus be less likely to progress to the misuse of other substances or engage in antisocial acts. Consistent with previous research, we found that ALDH2 deficiency was significantly associated with lower rates of drinking and getting drunk but not with ever having tried alcohol. Contrary to the gateway model, we found no evidence that ALDH2 deficiency was associated with lower rates of nonalcohol substance use or antisociality. Finally, in an examination of factors that may moderate the impact of the metabolic protection because of ALDH2 deficiency, we identified siblings rather than parents as the major source of familial environmental effect on adolescent drinking. En ligne : http://dx.doi.org/10.1017/s0954579407000612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182
in Development and Psychopathology > 19-4 (Fall 2007) . - p.1181-1195[article] Mendelian randomization: A novel test of the gateway hypothesis and models of gene–environment interplay [Texte imprimé et/ou numérique] / Daniel E. IRONS, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur ; William S. OETTING, Auteur . - 2007 . - p.1181-1195.
Langues : Anglais (eng)
in Development and Psychopathology > 19-4 (Fall 2007) . - p.1181-1195
Index. décimale : PER Périodiques Résumé : To determine if drinking behavior in adolescence provides a “gateway” leading to the misuse of other psychoactive substances and antisocial behavior, we genotyped 180 Asian adolescent adoptees to determine if they inherited the deficient from of the aldehyde dehydrogenase 2 (ALDH2) enzyme that is important in the metabolism of alcohol. Based on the gateway model, we hypothesized that those with normal enzyme activity (70% of the sample) who began to misuse alcohol would also misuse other drugs and display antisocial tendencies. Those with the enzyme deficiency (30%), because they experience unpleasant side effects associated with drinking, were expected to show less evidence of alcohol misuse and thus be less likely to progress to the misuse of other substances or engage in antisocial acts. Consistent with previous research, we found that ALDH2 deficiency was significantly associated with lower rates of drinking and getting drunk but not with ever having tried alcohol. Contrary to the gateway model, we found no evidence that ALDH2 deficiency was associated with lower rates of nonalcohol substance use or antisociality. Finally, in an examination of factors that may moderate the impact of the metabolic protection because of ALDH2 deficiency, we identified siblings rather than parents as the major source of familial environmental effect on adolescent drinking. En ligne : http://dx.doi.org/10.1017/s0954579407000612 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182