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Auteur Ieuan A. HUGHES |
Documents disponibles écrits par cet auteur (1)
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No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children / Karson T. F. KUNG in Journal of Child Psychology and Psychiatry, 57-12 (December 2016)
[article]
Titre : No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children Type de document : Texte imprimé et/ou numérique Auteurs : Karson T. F. KUNG, Auteur ; Debra SPENCER, Auteur ; Vickie PASTERSKI, Auteur ; Sharon NEUFELD, Auteur ; Vivette GLOVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Peter C. HINDMARSH, Auteur ; Ieuan A. HUGHES, Auteur ; Carlo L. ACERINI, Auteur ; Melissa HINES, Auteur Article en page(s) : p.1455-1462 Langues : Anglais (eng) Mots-clés : Congenital adrenal hyperplasia fetal testosterone prenatal testosterone exposure autism autistic traits extreme male brain Index. décimale : PER Périodiques Résumé : Background There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. Methods A parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years. Results Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample. Conclusions These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.12602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298
in Journal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1455-1462[article] No relationship between prenatal androgen exposure and autistic traits: convergent evidence from studies of children with congenital adrenal hyperplasia and of amniotic testosterone concentrations in typically developing children [Texte imprimé et/ou numérique] / Karson T. F. KUNG, Auteur ; Debra SPENCER, Auteur ; Vickie PASTERSKI, Auteur ; Sharon NEUFELD, Auteur ; Vivette GLOVER, Auteur ; Thomas G. O'CONNOR, Auteur ; Peter C. HINDMARSH, Auteur ; Ieuan A. HUGHES, Auteur ; Carlo L. ACERINI, Auteur ; Melissa HINES, Auteur . - p.1455-1462.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 57-12 (December 2016) . - p.1455-1462
Mots-clés : Congenital adrenal hyperplasia fetal testosterone prenatal testosterone exposure autism autistic traits extreme male brain Index. décimale : PER Périodiques Résumé : Background There is a marked male preponderance in autism spectrum conditions. The extreme male brain theory and the fetal androgen theory of autism suggest that elevated prenatal testosterone exposure is a key contributor to autistic traits. The current paper reports findings from two separate studies that test this hypothesis. Methods A parent-report questionnaire, the Childhood Autism Spectrum Test (CAST), was employed to measure autistic traits in both studies. The first study examined autistic traits in young children with congenital adrenal hyperplasia (CAH), a condition causing unusually high concentrations of testosterone prenatally in girls. Eighty one children with CAH (43 girls) and 72 unaffected relatives (41 girls), aged 4–11 years, were assessed. The second study examined autistic traits in relation to amniotic testosterone in 92 typically developing children (48 girls), aged 3–5 years. Results Findings from neither study supported the association between prenatal androgen (testosterone) exposure and autistic traits. Specifically, young girls with and without CAH did not differ significantly in CAST scores and amniotic testosterone concentrations were not significantly associated with CAST scores in boys, girls, or the whole sample. Conclusions These studies do not support a relationship between prenatal testosterone exposure and autistic traits. These findings augment prior research suggesting no consistent relationship between early androgen exposure and autistic traits. En ligne : http://dx.doi.org/10.1111/jcpp.12602 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298