Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Thomas WASSINK |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study / Molly LOSH in Journal of Autism and Developmental Disorders, 47-3 (March 2017)
[article]
Titre : Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study Type de document : Texte imprimé et/ou numérique Auteurs : Molly LOSH, Auteur ; Gary E. MARTIN, Auteur ; Michelle LEE, Auteur ; Jessica KLUSEK, Auteur ; John SIDERIS, Auteur ; Sheila BARRON, Auteur ; Thomas WASSINK, Auteur Article en page(s) : p.834-845 Langues : Anglais (eng) Mots-clés : Autism Genetics Endophenotype Longitudinal Broad autism phenotype Language Index. décimale : PER Périodiques Résumé : Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents’ childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents’ childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. En ligne : http://dx.doi.org/10.1007/s10803-016-2996-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304
in Journal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.834-845[article] Developmental Markers of Genetic Liability to Autism in Parents: A Longitudinal, Multigenerational Study [Texte imprimé et/ou numérique] / Molly LOSH, Auteur ; Gary E. MARTIN, Auteur ; Michelle LEE, Auteur ; Jessica KLUSEK, Auteur ; John SIDERIS, Auteur ; Sheila BARRON, Auteur ; Thomas WASSINK, Auteur . - p.834-845.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-3 (March 2017) . - p.834-845
Mots-clés : Autism Genetics Endophenotype Longitudinal Broad autism phenotype Language Index. décimale : PER Périodiques Résumé : Genetic liability to autism spectrum disorder (ASD) can be expressed in unaffected relatives through subclinical, genetically meaningful traits, or endophenotypes. This study aimed to identify developmental endophenotypes in parents of individuals with ASD by examining parents’ childhood academic development over the school-age period. A cohort of 139 parents of individuals with ASD were studied, along with their children with ASD and 28 controls. Parents’ childhood records in the domains of language, reading, and math were studied from grades K-12. Results indicated that relatively lower performance and slower development of skills (particularly language related skills), and an uneven rate of development across domains predicted ASD endophenotypes in adulthood for parents, and the severity of clinical symptoms in children with ASD. These findings may mark childhood indicators of genetic liability to ASD in parents, that could inform understanding of the subclinical expression of ASD genetic liability. En ligne : http://dx.doi.org/10.1007/s10803-016-2996-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304