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Détail de l'auteur
Auteur James MACKILLOP |
Documents disponibles écrits par cet auteur (2)
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Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life / Ayelet LAHAT in Development and Psychopathology, 29-3 (August 2017)
[article]
Titre : Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life Type de document : Texte imprimé et/ou numérique Auteurs : Ayelet LAHAT, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Karen J. MATHEWSON, Auteur ; James MACKILLOP, Auteur ; Saroj SAIGAL, Auteur ; Katherine M. MORRISON, Auteur ; Michael H. BOYLE, Auteur ; Louis A. SCHMIDT, Auteur Article en page(s) : p.837-843 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Extremely low birth weight (ELBW; 5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311
in Development and Psychopathology > 29-3 (August 2017) . - p.837-843[article] Extremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life [Texte imprimé et/ou numérique] / Ayelet LAHAT, Auteur ; Ryan J. VAN LIESHOUT, Auteur ; Karen J. MATHEWSON, Auteur ; James MACKILLOP, Auteur ; Saroj SAIGAL, Auteur ; Katherine M. MORRISON, Auteur ; Michael H. BOYLE, Auteur ; Louis A. SCHMIDT, Auteur . - p.837-843.
Langues : Anglais (eng)
in Development and Psychopathology > 29-3 (August 2017) . - p.837-843
Index. décimale : PER Périodiques Résumé : Abstract Extremely low birth weight (ELBW; 5-HTTLPR). We followed the oldest longitudinal cohort of ELBW survivors to adulthood. Participants provided buccal cells and reported on internalizing problems, using the Young Adult Self-Report when they were in their mid-20s (ELBW/SGA, N = 28; ELBW/AGA, N = 60; NBW, N = 81) and mid-30s (ELBW/SGA, N = 27; ELBW/AGA, N = 58; NBW, N = 76). The findings indicate that ELBW/SGAs carrying the 5-HTTLPR short allele reported increased internalizing problems, particularly depression, during the third and fourth decades of life. This is the first known report on gene–environment interactions predicting psychopathology among ELBW survivors. Our findings elucidate putative neurobiological pathways that underlie risk for psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579416000511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=311 Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood / Assaf OSHRI in Development and Psychopathology, 30-2 (May 2018)
[article]
Titre : Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Assaf OSHRI, Auteur ; Steve M. KOGAN, Auteur ; Josephine A. KWON, Auteur ; K. A. S. WICKRAMA, Auteur ; Lauren VANDERBROEK, Auteur ; Abraham A. PALMER, Auteur ; James MACKILLOP, Auteur Article en page(s) : p.417-435 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Emerging developmental perspectives suggest that adverse rearing environments promote neurocognitive adaptations that heighten impulsivity and increase vulnerability to risky behavior. Although studies document links between harsh rearing environments and impulsive behavior on substance use, the developmental hypothesis that impulsivity acts as mechanism linking adverse rearing environments to downstream substance use remains to be investigated. The present study investigated the role of impulsivity in linking child abuse and neglect with adult substance use using data from (a) a longitudinal sample of youth (Study 1, N = 9,421) and (b) a cross-sectional sample of adults (Study 2, N = 1,011). In Study 1, the links between child abuse and neglect and young adult smoking and marijuana use were mediated by increases in adolescent impulsivity. In Study 2, indirect links between child abuse and neglect and substance use were evidenced via delayed reward discounting and impulsivity traits. Among impulsivity subcomponents, robust indirect effects connecting childhood experiences to cigarette use emerged for negative urgency. Negative urgency, positive urgency, and sensation seeking mediated the effect of child abuse and neglect on cannabis and alcohol use. Results suggest that child abuse and neglect increases risk for substance use in part, due to effects on impulsivity. Individuals with adverse childhood experiences may benefit from substance use preventive intervention programs that target impulsive behaviors. En ligne : http://dx.doi.org/10.1017/S0954579417000943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358
in Development and Psychopathology > 30-2 (May 2018) . - p.417-435[article] Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood [Texte imprimé et/ou numérique] / Assaf OSHRI, Auteur ; Steve M. KOGAN, Auteur ; Josephine A. KWON, Auteur ; K. A. S. WICKRAMA, Auteur ; Lauren VANDERBROEK, Auteur ; Abraham A. PALMER, Auteur ; James MACKILLOP, Auteur . - p.417-435.
Langues : Anglais (eng)
in Development and Psychopathology > 30-2 (May 2018) . - p.417-435
Index. décimale : PER Périodiques Résumé : Emerging developmental perspectives suggest that adverse rearing environments promote neurocognitive adaptations that heighten impulsivity and increase vulnerability to risky behavior. Although studies document links between harsh rearing environments and impulsive behavior on substance use, the developmental hypothesis that impulsivity acts as mechanism linking adverse rearing environments to downstream substance use remains to be investigated. The present study investigated the role of impulsivity in linking child abuse and neglect with adult substance use using data from (a) a longitudinal sample of youth (Study 1, N = 9,421) and (b) a cross-sectional sample of adults (Study 2, N = 1,011). In Study 1, the links between child abuse and neglect and young adult smoking and marijuana use were mediated by increases in adolescent impulsivity. In Study 2, indirect links between child abuse and neglect and substance use were evidenced via delayed reward discounting and impulsivity traits. Among impulsivity subcomponents, robust indirect effects connecting childhood experiences to cigarette use emerged for negative urgency. Negative urgency, positive urgency, and sensation seeking mediated the effect of child abuse and neglect on cannabis and alcohol use. Results suggest that child abuse and neglect increases risk for substance use in part, due to effects on impulsivity. Individuals with adverse childhood experiences may benefit from substance use preventive intervention programs that target impulsive behaviors. En ligne : http://dx.doi.org/10.1017/S0954579417000943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358