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Détail de l'auteur
Auteur K. L. EAGLESON |
Documents disponibles écrits par cet auteur (1)
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A new synaptic player leading to autism risk: Met receptor tyrosine kinase / M. C. JUDSON in Journal of Neurodevelopmental Disorders, 3-3 (September 2011)
[article]
Titre : A new synaptic player leading to autism risk: Met receptor tyrosine kinase Type de document : Texte imprimé et/ou numérique Auteurs : M. C. JUDSON, Auteur ; K. L. EAGLESON, Auteur ; P. LEVITT, Auteur Article en page(s) : p.282-92 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The validity for assigning disorder risk to an autism spectrum disorder (ASD) candidate gene comes from convergent genetic, clinical, and developmental neurobiology data. Here, we review these lines of evidence from multiple human genetic studies, and non-human primate and mouse experiments that support the conclusion that the MET receptor tyrosine kinase (RTK) functions to influence synapse development in circuits relevant to certain core behavioral domains of ASD. There is association of both common functional alleles and rare copy number variants that impact levels of MET expression in the human cortex. The timing of Met expression is linked to axon terminal outgrowth and synaptogenesis in the developing rodent and primate forebrain, and both in vitro and in vivo studies implicate this RTK in dendritic branching, spine maturation, and excitatory connectivity in the neocortex. This impact can occur in a cell-nonautonomous fashion, emphasizing the unique role that Met plays in specific circuits relevant to ASD. En ligne : http://dx.doi.org/10.1007/s11689-011-9081-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343
in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.282-92[article] A new synaptic player leading to autism risk: Met receptor tyrosine kinase [Texte imprimé et/ou numérique] / M. C. JUDSON, Auteur ; K. L. EAGLESON, Auteur ; P. LEVITT, Auteur . - p.282-92.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 3-3 (September 2011) . - p.282-92
Index. décimale : PER Périodiques Résumé : The validity for assigning disorder risk to an autism spectrum disorder (ASD) candidate gene comes from convergent genetic, clinical, and developmental neurobiology data. Here, we review these lines of evidence from multiple human genetic studies, and non-human primate and mouse experiments that support the conclusion that the MET receptor tyrosine kinase (RTK) functions to influence synapse development in circuits relevant to certain core behavioral domains of ASD. There is association of both common functional alleles and rare copy number variants that impact levels of MET expression in the human cortex. The timing of Met expression is linked to axon terminal outgrowth and synaptogenesis in the developing rodent and primate forebrain, and both in vitro and in vivo studies implicate this RTK in dendritic branching, spine maturation, and excitatory connectivity in the neocortex. This impact can occur in a cell-nonautonomous fashion, emphasizing the unique role that Met plays in specific circuits relevant to ASD. En ligne : http://dx.doi.org/10.1007/s11689-011-9081-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=343