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Auteur Sabrina KRAUSE |
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History of child maltreatment and telomere length in immune cell subsets: Associations with stress- and attachment-related hormones / Christina BOECK in Development and Psychopathology, 30-2 (May 2018)
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Titre : History of child maltreatment and telomere length in immune cell subsets: Associations with stress- and attachment-related hormones Type de document : Texte imprimé et/ou numérique Auteurs : Christina BOECK, Auteur ; Sabrina KRAUSE, Auteur ; Alexander KARABATSIAKIS, Auteur ; Katharina SCHURY, Auteur ; Harald GÜNDEL, Auteur ; Christiane WALLER, Auteur ; Iris-Tatjana KOLASSA, Auteur Article en page(s) : p.539-551 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Experiencing maltreatment during childhood can have long-lasting consequences for both mental and physical health. Immune cell telomere length (TL) shortening might be one link between child maltreatment (CM) experiences and adverse health outcomes later in life. While the stress hormone cortisol has been associated with TL attrition, the attachment-related hormone oxytocin may promote resilience. In 15 mothers with and 15 age- and body mass index-matched mothers without CM, we assessed TL in peripheral blood mononuclear cells and selected immune cell subsets (monocytes, naive, and memory cytotoxic T cells) by quantitative fluorescence in situ hybridization, as well as peripheral cortisol and oxytocin levels. Memory cytotoxic T cells showed significantly shorter TL in association with CM, whereas TL in monocytes and naive cytotoxic T cells did not significantly differ between the two groups. Across both groups, cortisol was negatively associated with TL, while oxytocin was positively associated with TL in memory cytotoxic T cells. These results indicate that long-lived memory cytotoxic T cells are most affected by the increased biological stress state associated with CM. Keeping in mind the correlational and preliminary nature of the results, the data suggest that cortisol may have a damaging and oxytocin a protective function on TL. En ligne : http://dx.doi.org/10.1017/S0954579417001055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359
in Development and Psychopathology > 30-2 (May 2018) . - p.539-551[article] History of child maltreatment and telomere length in immune cell subsets: Associations with stress- and attachment-related hormones [Texte imprimé et/ou numérique] / Christina BOECK, Auteur ; Sabrina KRAUSE, Auteur ; Alexander KARABATSIAKIS, Auteur ; Katharina SCHURY, Auteur ; Harald GÜNDEL, Auteur ; Christiane WALLER, Auteur ; Iris-Tatjana KOLASSA, Auteur . - p.539-551.
Langues : Anglais (eng)
in Development and Psychopathology > 30-2 (May 2018) . - p.539-551
Index. décimale : PER Périodiques Résumé : Experiencing maltreatment during childhood can have long-lasting consequences for both mental and physical health. Immune cell telomere length (TL) shortening might be one link between child maltreatment (CM) experiences and adverse health outcomes later in life. While the stress hormone cortisol has been associated with TL attrition, the attachment-related hormone oxytocin may promote resilience. In 15 mothers with and 15 age- and body mass index-matched mothers without CM, we assessed TL in peripheral blood mononuclear cells and selected immune cell subsets (monocytes, naive, and memory cytotoxic T cells) by quantitative fluorescence in situ hybridization, as well as peripheral cortisol and oxytocin levels. Memory cytotoxic T cells showed significantly shorter TL in association with CM, whereas TL in monocytes and naive cytotoxic T cells did not significantly differ between the two groups. Across both groups, cortisol was negatively associated with TL, while oxytocin was positively associated with TL in memory cytotoxic T cells. These results indicate that long-lived memory cytotoxic T cells are most affected by the increased biological stress state associated with CM. Keeping in mind the correlational and preliminary nature of the results, the data suggest that cortisol may have a damaging and oxytocin a protective function on TL. En ligne : http://dx.doi.org/10.1017/S0954579417001055 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359