Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur V. QUADROS EDWARD |
Documents disponibles écrits par cet auteur (1)
Faire une suggestion Affiner la recherche
Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents / V. QUADROS EDWARD in Autism Research, 11-5 (May 2018)
[article]
Titre : Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents Type de document : Texte imprimé et/ou numérique Auteurs : V. QUADROS EDWARD, Auteur ; M. SEQUEIRA JEFFREY, Auteur ; W. Ted BROWN, Auteur ; Clifford MEVS, Auteur ; Elaine MARCHI, Auteur ; Michael FLORY, Auteur ; C. JENKINS EDMUND, Auteur ; T. VELINOV MILEN, Auteur ; Ira L. COHEN, Auteur Article en page(s) : p.707-712 Langues : Anglais (eng) Mots-clés : autism folate receptor autoantibodies Index. décimale : PER Périodiques Résumé : Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FR?) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls. Overall, 76% of the affected children, 75% of the unaffected siblings, 69% of fathers and 59% of mothers were positive for either blocking or binding Ab, whereas the prevalence of this Ab in the normal controls was 29%. The Ab was highly prevalent in affected families including unaffected siblings. The appearance of these antibodies may have a familial origin but the risk of developing ASD is likely influenced by other mitigating factors since some siblings who had the antibodies were not affected. The antibody response appears heritable with the blocking autoantibody in the parents and affected child increasing the risk of ASD. Autism Res 2018, 11: 707?712. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Folate is an essential nutrient during fetal and infant development. Autoantibodies against the folate receptor alpha can block folate transport from the mother to the fetus and to the brain in infants. Children diagnosed with autism and their immediate family members were evaluated for the prevalence of folate receptor autoantibodies. The autoantibody was highly prevalent in affected families with similar distribution in parents, normal siblings and affected children. The presence of these antibodies appears to have a familial origin and may contribute to developmental deficits when combined with other factors. En ligne : https://doi.org/10.1002/aur.1934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363
in Autism Research > 11-5 (May 2018) . - p.707-712[article] Folate receptor autoantibodies are prevalent in children diagnosed with autism spectrum disorder, their normal siblings and parents [Texte imprimé et/ou numérique] / V. QUADROS EDWARD, Auteur ; M. SEQUEIRA JEFFREY, Auteur ; W. Ted BROWN, Auteur ; Clifford MEVS, Auteur ; Elaine MARCHI, Auteur ; Michael FLORY, Auteur ; C. JENKINS EDMUND, Auteur ; T. VELINOV MILEN, Auteur ; Ira L. COHEN, Auteur . - p.707-712.
Langues : Anglais (eng)
in Autism Research > 11-5 (May 2018) . - p.707-712
Mots-clés : autism folate receptor autoantibodies Index. décimale : PER Périodiques Résumé : Folate deficiency can affect fetal and neonatal brain development Considering the reported association of Folate receptor alpha (FR?) autoantibodies (Abs) with autism and developmental disorders, we sought to confirm this in families of 82 children with ASD, 53 unaffected siblings, 65 fathers, and 70 mothers, along with 52 unrelated normal controls. Overall, 76% of the affected children, 75% of the unaffected siblings, 69% of fathers and 59% of mothers were positive for either blocking or binding Ab, whereas the prevalence of this Ab in the normal controls was 29%. The Ab was highly prevalent in affected families including unaffected siblings. The appearance of these antibodies may have a familial origin but the risk of developing ASD is likely influenced by other mitigating factors since some siblings who had the antibodies were not affected. The antibody response appears heritable with the blocking autoantibody in the parents and affected child increasing the risk of ASD. Autism Res 2018, 11: 707?712. ? 2018 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Folate is an essential nutrient during fetal and infant development. Autoantibodies against the folate receptor alpha can block folate transport from the mother to the fetus and to the brain in infants. Children diagnosed with autism and their immediate family members were evaluated for the prevalence of folate receptor autoantibodies. The autoantibody was highly prevalent in affected families with similar distribution in parents, normal siblings and affected children. The presence of these antibodies appears to have a familial origin and may contribute to developmental deficits when combined with other factors. En ligne : https://doi.org/10.1002/aur.1934 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363