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Auteur M. S. KOBOR |
Documents disponibles écrits par cet auteur (2)
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An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior / E. CONRADT in Development and Psychopathology, 30-3 (August 2018)
[article]
Titre : An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior Type de document : Texte imprimé et/ou numérique Auteurs : E. CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; S. E. CROWELL, Auteur ; C. MONK, Auteur ; M. S. KOBOR, Auteur Article en page(s) : p.881-890 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Development and Psychopathology > 30-3 (August 2018) . - p.881-890[article] An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior [Texte imprimé et/ou numérique] / E. CONRADT, Auteur ; Daniel E. ADKINS, Auteur ; S. E. CROWELL, Auteur ; C. MONK, Auteur ; M. S. KOBOR, Auteur . - p.881-890.
Langues : Anglais (eng)
in Development and Psychopathology > 30-3 (August 2018) . - p.881-890
Index. décimale : PER Périodiques Résumé : Following recent advances in behavioral and psychiatric epigenetics, researchers are increasingly using epigenetic methods to study prenatal exposure to maternal mood disorder and its effects on fetal and newborn neurobehavior. Despite notable progress, various methodological limitations continue to obscure our understanding of the epigenetic mechanisms underpinning prenatal exposure to maternal mood disorder on newborn neurobehavioral development. Here we detail this problem, discussing limitations of the currently dominant analytical approaches (i.e., candidate epigenetic and epigenome-wide association studies), then present a solution that retains many benefits of existing methods while minimizing their shortcomings: epigenetic pathway analysis. We argue that the application of pathway-based epigenetic approaches that target DNA methylation at transcription factor binding sites could substantially deepen our mechanistic understanding of how prenatal exposures influence newborn neurobehavior. En ligne : http://dx.doi.org/10.1017/s0954579418000688 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 The early care environment and DNA methylome variation in childhood / E. GARG in Development and Psychopathology, 30-3 (August 2018)
[article]
Titre : The early care environment and DNA methylome variation in childhood Type de document : Texte imprimé et/ou numérique Auteurs : E. GARG, Auteur ; L. CHEN, Auteur ; T. T. T. NGUYEN, Auteur ; I. POKHVISNEVA, Auteur ; L. M. CHEN, Auteur ; E. UNTERNAEHRER, Auteur ; J. L. MACISAAC, Auteur ; L. M. MCEWEN, Auteur ; S. M. MAH, Auteur ; H. GAUDREAU, Auteur ; R. LEVITAN, Auteur ; E. MOSS, Auteur ; M. B. SOKOLOWSKI, Auteur ; J. L. KENNEDY, Auteur ; M. S. STEINER, Auteur ; M. J. MEANEY, Auteur ; J. D. HOLBROOK, Auteur ; P. P. SILVEIRA, Auteur ; N. KARNANI, Auteur ; M. S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur Article en page(s) : p.891-903 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Development and Psychopathology > 30-3 (August 2018) . - p.891-903[article] The early care environment and DNA methylome variation in childhood [Texte imprimé et/ou numérique] / E. GARG, Auteur ; L. CHEN, Auteur ; T. T. T. NGUYEN, Auteur ; I. POKHVISNEVA, Auteur ; L. M. CHEN, Auteur ; E. UNTERNAEHRER, Auteur ; J. L. MACISAAC, Auteur ; L. M. MCEWEN, Auteur ; S. M. MAH, Auteur ; H. GAUDREAU, Auteur ; R. LEVITAN, Auteur ; E. MOSS, Auteur ; M. B. SOKOLOWSKI, Auteur ; J. L. KENNEDY, Auteur ; M. S. STEINER, Auteur ; M. J. MEANEY, Auteur ; J. D. HOLBROOK, Auteur ; P. P. SILVEIRA, Auteur ; N. KARNANI, Auteur ; M. S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur . - p.891-903.
Langues : Anglais (eng)
in Development and Psychopathology > 30-3 (August 2018) . - p.891-903
Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366