Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur L. FANANAS |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Cortisol, cortisone, and BDNF in amniotic fluid in the second trimester of pregnancy: Effect of early life and current maternal stress and socioeconomic status / M. DEUSCHLE in Development and Psychopathology, 30-3 (August 2018)
[article]
Titre : Cortisol, cortisone, and BDNF in amniotic fluid in the second trimester of pregnancy: Effect of early life and current maternal stress and socioeconomic status Type de document : Texte imprimé et/ou numérique Auteurs : M. DEUSCHLE, Auteur ; F. HENDLMEIER, Auteur ; S. WITT, Auteur ; M. RIETSCHEL, Auteur ; M. GILLES, Auteur ; A. SANCHEZ-GUIJO, Auteur ; L. FANANAS, Auteur ; S. HENTZE, Auteur ; S. A. WUDY, Auteur ; R. HELLWEG, Auteur Article en page(s) : p.971-980 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The prenatal environment shapes the offspring's phenotype; moreover, transgenerational stress and stress during pregnancy may play a role. Brain-derived neurotrophic factor (BDNF) and glucocorticoids influence neurodevelopment during pregnancy, and there is evidence that BDNF in amniotic fluid is mainly of fetal origin, while the source of glucocorticoids is maternal. We tested the hypothesis that maternal early life stress, psychiatric diagnoses, anxiety, perceived stress, and socioeconomic status influence BDNF and glucocorticoid concentrations in amniotic fluid in the second trimester. We studied 79 pregnant women who underwent amniocentesis in the early second trimester and analyzed BDNF, cortisol, and cortisone concentrations in amniotic fluid. The endocrine data were related to maternal early life adversities (Childhood Trauma Questionaire), perceived stress (Perceived Stress Scale), anxiety, socioeconomic status (family income), and the presence of psychiatric diseases. We found BDNF in amniotic fluid to be positively related to maternal early adversity (Childhood Trauma Questionaire). Low family income (socioeconomic status) was related to high amniotic fluid glucocorticoid concentrations. Neither glucocorticoid concentrations nor hydroxy steroid dehydrogenase (HSD2) activity could be related to BDNF concentrations in amniotic fluid. Early maternal adverse events may be reflected in the fetal BDNF regulation, and it should be tested whether this relates to differences in neurodevelopment. En ligne : http://dx.doi.org/10.1017/s0954579418000147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366
in Development and Psychopathology > 30-3 (August 2018) . - p.971-980[article] Cortisol, cortisone, and BDNF in amniotic fluid in the second trimester of pregnancy: Effect of early life and current maternal stress and socioeconomic status [Texte imprimé et/ou numérique] / M. DEUSCHLE, Auteur ; F. HENDLMEIER, Auteur ; S. WITT, Auteur ; M. RIETSCHEL, Auteur ; M. GILLES, Auteur ; A. SANCHEZ-GUIJO, Auteur ; L. FANANAS, Auteur ; S. HENTZE, Auteur ; S. A. WUDY, Auteur ; R. HELLWEG, Auteur . - p.971-980.
Langues : Anglais (eng)
in Development and Psychopathology > 30-3 (August 2018) . - p.971-980
Index. décimale : PER Périodiques Résumé : The prenatal environment shapes the offspring's phenotype; moreover, transgenerational stress and stress during pregnancy may play a role. Brain-derived neurotrophic factor (BDNF) and glucocorticoids influence neurodevelopment during pregnancy, and there is evidence that BDNF in amniotic fluid is mainly of fetal origin, while the source of glucocorticoids is maternal. We tested the hypothesis that maternal early life stress, psychiatric diagnoses, anxiety, perceived stress, and socioeconomic status influence BDNF and glucocorticoid concentrations in amniotic fluid in the second trimester. We studied 79 pregnant women who underwent amniocentesis in the early second trimester and analyzed BDNF, cortisol, and cortisone concentrations in amniotic fluid. The endocrine data were related to maternal early life adversities (Childhood Trauma Questionaire), perceived stress (Perceived Stress Scale), anxiety, socioeconomic status (family income), and the presence of psychiatric diseases. We found BDNF in amniotic fluid to be positively related to maternal early adversity (Childhood Trauma Questionaire). Low family income (socioeconomic status) was related to high amniotic fluid glucocorticoid concentrations. Neither glucocorticoid concentrations nor hydroxy steroid dehydrogenase (HSD2) activity could be related to BDNF concentrations in amniotic fluid. Early maternal adverse events may be reflected in the fetal BDNF regulation, and it should be tested whether this relates to differences in neurodevelopment. En ligne : http://dx.doi.org/10.1017/s0954579418000147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer / J. FORES-MARTOS in Molecular Autism, 10 (2019)
[article]
Titre : Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer Type de document : Texte imprimé et/ou numérique Auteurs : J. FORES-MARTOS, Auteur ; F. CATALA-LOPEZ, Auteur ; J. SANCHEZ-VALLE, Auteur ; K. IBANEZ, Auteur ; H. TEJERO, Auteur ; H. PALMA-GUDIEL, Auteur ; J. CLIMENT, Auteur ; V. PANCALDI, Auteur ; L. FANANAS, Auteur ; C. ARANGO, Auteur ; Mara PARELLADA, Auteur ; A. BAUDOT, Auteur ; D. VOGT, Auteur ; J. L. RUBENSTEIN, Auteur ; A. VALENCIA, Auteur ; R. TABARES-SEISDEDOS, Auteur Article en page(s) : 17 p. Langues : Anglais (eng) Mots-clés : asd Autism Cancer Comorbidity Gene expression Meta-analysis Multimorbidity Transcriptome Index. décimale : PER Périodiques Résumé : Background: Epidemiological and clinical evidence points to cancer as a comorbidity in people with autism spectrum disorders (ASD). A significant overlap of genes and biological processes between both diseases has also been reported. Methods: Here, for the first time, we compared the gene expression profiles of ASD frontal cortex tissues and 22 cancer types obtained by differential expression meta-analysis and report gene, pathway, and drug set-based overlaps between them. Results: Four cancer types (brain, thyroid, kidney, and pancreatic cancers) presented a significant overlap in gene expression deregulations in the same direction as ASD whereas two cancer types (lung and prostate cancers) showed differential expression profiles significantly deregulated in the opposite direction from ASD. Functional enrichment and LINCS L1000 based drug set enrichment analyses revealed the implication of several biological processes and pathways that were affected jointly in both diseases, including impairments of the immune system, and impairments in oxidative phosphorylation and ATP synthesis among others. Our data also suggest that brain and kidney cancer have patterns of transcriptomic dysregulation in the PI3K/AKT/MTOR axis that are similar to those found in ASD. Conclusions: Comparisons of ASD and cancer differential gene expression meta-analysis results suggest that brain, kidney, thyroid, and pancreatic cancers are candidates for direct comorbid associations with ASD. On the other hand, lung and prostate cancers are candidates for inverse comorbid associations with ASD. Joint perturbations in a set of specific biological processes underlie these associations which include several pathways previously implicated in both cancer and ASD encompassing immune system alterations, impairments of energy metabolism, cell cycle, and signaling through PI3K and G protein-coupled receptors among others. These findings could help to explain epidemiological observations pointing towards direct and inverse comorbid associations between ASD and specific cancer types and depict a complex scenario regarding the molecular patterns of association between ASD and cancer. En ligne : http://dx.doi.org/10.1186/s13229-019-0262-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=398
in Molecular Autism > 10 (2019) . - 17 p.[article] Transcriptomic metaanalyses of autistic brains reveals shared gene expression and biological pathway abnormalities with cancer [Texte imprimé et/ou numérique] / J. FORES-MARTOS, Auteur ; F. CATALA-LOPEZ, Auteur ; J. SANCHEZ-VALLE, Auteur ; K. IBANEZ, Auteur ; H. TEJERO, Auteur ; H. PALMA-GUDIEL, Auteur ; J. CLIMENT, Auteur ; V. PANCALDI, Auteur ; L. FANANAS, Auteur ; C. ARANGO, Auteur ; Mara PARELLADA, Auteur ; A. BAUDOT, Auteur ; D. VOGT, Auteur ; J. L. RUBENSTEIN, Auteur ; A. VALENCIA, Auteur ; R. TABARES-SEISDEDOS, Auteur . - 17 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 17 p.
Mots-clés : asd Autism Cancer Comorbidity Gene expression Meta-analysis Multimorbidity Transcriptome Index. décimale : PER Périodiques Résumé : Background: Epidemiological and clinical evidence points to cancer as a comorbidity in people with autism spectrum disorders (ASD). A significant overlap of genes and biological processes between both diseases has also been reported. Methods: Here, for the first time, we compared the gene expression profiles of ASD frontal cortex tissues and 22 cancer types obtained by differential expression meta-analysis and report gene, pathway, and drug set-based overlaps between them. Results: Four cancer types (brain, thyroid, kidney, and pancreatic cancers) presented a significant overlap in gene expression deregulations in the same direction as ASD whereas two cancer types (lung and prostate cancers) showed differential expression profiles significantly deregulated in the opposite direction from ASD. Functional enrichment and LINCS L1000 based drug set enrichment analyses revealed the implication of several biological processes and pathways that were affected jointly in both diseases, including impairments of the immune system, and impairments in oxidative phosphorylation and ATP synthesis among others. Our data also suggest that brain and kidney cancer have patterns of transcriptomic dysregulation in the PI3K/AKT/MTOR axis that are similar to those found in ASD. Conclusions: Comparisons of ASD and cancer differential gene expression meta-analysis results suggest that brain, kidney, thyroid, and pancreatic cancers are candidates for direct comorbid associations with ASD. On the other hand, lung and prostate cancers are candidates for inverse comorbid associations with ASD. Joint perturbations in a set of specific biological processes underlie these associations which include several pathways previously implicated in both cancer and ASD encompassing immune system alterations, impairments of energy metabolism, cell cycle, and signaling through PI3K and G protein-coupled receptors among others. These findings could help to explain epidemiological observations pointing towards direct and inverse comorbid associations between ASD and specific cancer types and depict a complex scenario regarding the molecular patterns of association between ASD and cancer. En ligne : http://dx.doi.org/10.1186/s13229-019-0262-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=398