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Auteur M. P. LOPEZ-LARSON |
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Decreased anterior cingulate activation in a motor task in youths with bipolar disorder / J. B. KING in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)
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Titre : Decreased anterior cingulate activation in a motor task in youths with bipolar disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. B. KING, Auteur ; Jeffrey S. ANDERSON, Auteur ; D. A. YURGELUN-TODD, Auteur ; P. SUBRAMANIAM, Auteur ; M. R. EHRLER, Auteur ; M. P. LOPEZ-LARSON, Auteur Article en page(s) : p.900-907 Langues : Anglais (eng) Mots-clés : Bipolar disorder adolescents anterior cingulate fMRI finger tapping Index. décimale : PER Périodiques Résumé : BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between-group whole-brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole-brain false discovery rate (FDR) correction (qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention-deficit/hyperactivity disorder (ADHD) in the BP group were also conducted. RESULTS: Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP. CONCLUSIONS: These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP. En ligne : http://dx.doi.org/10.1111/jcpp.12875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368
in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.900-907[article] Decreased anterior cingulate activation in a motor task in youths with bipolar disorder [Texte imprimé et/ou numérique] / J. B. KING, Auteur ; Jeffrey S. ANDERSON, Auteur ; D. A. YURGELUN-TODD, Auteur ; P. SUBRAMANIAM, Auteur ; M. R. EHRLER, Auteur ; M. P. LOPEZ-LARSON, Auteur . - p.900-907.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-8 (August 2018) . - p.900-907
Mots-clés : Bipolar disorder adolescents anterior cingulate fMRI finger tapping Index. décimale : PER Périodiques Résumé : BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between-group whole-brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole-brain false discovery rate (FDR) correction (qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention-deficit/hyperactivity disorder (ADHD) in the BP group were also conducted. RESULTS: Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP. CONCLUSIONS: These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP. En ligne : http://dx.doi.org/10.1111/jcpp.12875 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368