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Auteur K. KONRAD |
Documents disponibles écrits par cet auteur (2)
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A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder / P. SHAW in Journal of Child Psychology and Psychiatry, 59-10 (October 2018)
[article]
Titre : A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : P. SHAW, Auteur ; A. ISHII-TAKAHASHI, Auteur ; M. T. PARK, Auteur ; G. A. DEVENYI, Auteur ; C. ZIBMAN, Auteur ; S. KASPAREK, Auteur ; G. SUDRE, Auteur ; A. MANGALMURTI, Auteur ; M. HOOGMAN, Auteur ; H. TIEMEIER, Auteur ; Georg G. VON POLIER, Auteur ; D. SHOOK, Auteur ; R. MUETZEL, Auteur ; M. M. CHAKRAVARTY, Auteur ; K. KONRAD, Auteur ; S. DURSTON, Auteur ; T. WHITE, Auteur Article en page(s) : p.1114-1123 Langues : Anglais (eng) Mots-clés : Cerebellum attention deficit hyperactivity disorder growth meta-analysis neuroanatomy white matter Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum supports many cognitive functions disrupted in attention deficit hyperactivity disorder (ADHD). Prior neuroanatomic studies have been often limited by small sample sizes, inconsistent findings, and a reliance on cross-sectional data, limiting inferences about cerebellar development. Here, we conduct a multicohort study using longitudinal data, to characterize cerebellar development. METHODS: Growth trajectories of the cerebellar vermis, hemispheres and white matter were estimated using piecewise linear regression from 1,656 youth; of whom 63% had longitudinal data, totaling 2,914 scans. Four cohorts participated, all contained childhood data (age 4-12 years); two had adolescent data (12-25 years). Growth parameters were combined using random-effects meta-analysis. RESULTS: Diagnostic differences in growth were confined to the corpus medullare (cerebellar white matter). Here, the ADHD group showed slower growth in early childhood compared to the typically developing group (left corpus medullare z = 2.49, p = .01; right z = 2.03, p = .04). This reversed in late childhood, with faster growth in ADHD in the left corpus medullare (z = 2.06, p = .04). Findings held when gender, intelligence, comorbidity, and psychostimulant medication were considered. DISCUSSION: Across four independent cohorts, containing predominately longitudinal data, we found diagnostic differences in the growth of cerebellar white matter. In ADHD, slower white matter growth in early childhood was followed by faster growth in late childhood. The findings are consistent with the concept of ADHD as a disorder of the brain's structural connections, formed partly by developing cortico-cerebellar white matter tracts. En ligne : http://dx.doi.org/10.1111/jcpp.12920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369
in Journal of Child Psychology and Psychiatry > 59-10 (October 2018) . - p.1114-1123[article] A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder [Texte imprimé et/ou numérique] / P. SHAW, Auteur ; A. ISHII-TAKAHASHI, Auteur ; M. T. PARK, Auteur ; G. A. DEVENYI, Auteur ; C. ZIBMAN, Auteur ; S. KASPAREK, Auteur ; G. SUDRE, Auteur ; A. MANGALMURTI, Auteur ; M. HOOGMAN, Auteur ; H. TIEMEIER, Auteur ; Georg G. VON POLIER, Auteur ; D. SHOOK, Auteur ; R. MUETZEL, Auteur ; M. M. CHAKRAVARTY, Auteur ; K. KONRAD, Auteur ; S. DURSTON, Auteur ; T. WHITE, Auteur . - p.1114-1123.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 59-10 (October 2018) . - p.1114-1123
Mots-clés : Cerebellum attention deficit hyperactivity disorder growth meta-analysis neuroanatomy white matter Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum supports many cognitive functions disrupted in attention deficit hyperactivity disorder (ADHD). Prior neuroanatomic studies have been often limited by small sample sizes, inconsistent findings, and a reliance on cross-sectional data, limiting inferences about cerebellar development. Here, we conduct a multicohort study using longitudinal data, to characterize cerebellar development. METHODS: Growth trajectories of the cerebellar vermis, hemispheres and white matter were estimated using piecewise linear regression from 1,656 youth; of whom 63% had longitudinal data, totaling 2,914 scans. Four cohorts participated, all contained childhood data (age 4-12 years); two had adolescent data (12-25 years). Growth parameters were combined using random-effects meta-analysis. RESULTS: Diagnostic differences in growth were confined to the corpus medullare (cerebellar white matter). Here, the ADHD group showed slower growth in early childhood compared to the typically developing group (left corpus medullare z = 2.49, p = .01; right z = 2.03, p = .04). This reversed in late childhood, with faster growth in ADHD in the left corpus medullare (z = 2.06, p = .04). Findings held when gender, intelligence, comorbidity, and psychostimulant medication were considered. DISCUSSION: Across four independent cohorts, containing predominately longitudinal data, we found diagnostic differences in the growth of cerebellar white matter. In ADHD, slower white matter growth in early childhood was followed by faster growth in late childhood. The findings are consistent with the concept of ADHD as a disorder of the brain's structural connections, formed partly by developing cortico-cerebellar white matter tracts. En ligne : http://dx.doi.org/10.1111/jcpp.12920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder / K. KONRAD in Journal of Child Psychology and Psychiatry, 63-2 (February 2022)
[article]
Titre : Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. KONRAD, Auteur ; G. KOHLS, Auteur ; S. BAUMANN, Auteur ; A. BERNHARD, Auteur ; A. MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; A. SMARAGDI, Auteur ; K. GONZALEZ-MADRUGA, Auteur ; A. WELLS, Auteur ; J. C. ROGERS, Auteur ; R. PAULI, Auteur ; R. CLANTON, Auteur ; R. BAKER, Auteur ; L. KERSTEN, Auteur ; M. PRÄTZLICH, Auteur ; H. OLDENHOF, Auteur ; L. JANSEN, Auteur ; A. KLEEVEN, Auteur ; Aitana BIGORRA, Auteur ; A. HERVAS, Auteur ; I. KEREXETA-LIZEAGA, Auteur ; E. SESMA-PARDO, Auteur ; M. ANGEL GONZALEZ-TORRES, Auteur ; R. SIKLÓSI, Auteur ; R. DOCHNAL, Auteur ; Z. KALOGERAKIS, Auteur ; M. PIRLYMPOU, Auteur ; L. PAPADAKOS, Auteur ; H. CORNWELL, Auteur ; W. SCHARKE, Auteur ; Dimitris DIKEOS, Auteur ; A. FERNÁNDEZ-RIVAS, Auteur ; A. POPMA, Auteur ; C. STADLER, Auteur ; B. HERPERTZ-DAHLMANN, Auteur ; Stephane A. DE BRITO, Auteur ; G. FAIRCHILD, Auteur ; C. M. FREITAG, Auteur Article en page(s) : p.218-228 Langues : Anglais (eng) Mots-clés : Conduct disorder callous-unemotional traits psychiatric comorbidity sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the 'gender paradox' and 'delayed-onset pathway' hypotheses of female CD. METHODS: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9-18?years), compared to 864 sex- and age-matched typically developing controls. RESULTS: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the 'gender paradox' hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the 'delayed-onset pathway' hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology. CONCLUSIONS: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the 'gender paradox' and 'delayed-onset pathway' hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes. En ligne : http://dx.doi.org/10.1111/jcpp.13428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.218-228[article] Sex differences in psychiatric comorbidity and clinical presentation in youths with conduct disorder [Texte imprimé et/ou numérique] / K. KONRAD, Auteur ; G. KOHLS, Auteur ; S. BAUMANN, Auteur ; A. BERNHARD, Auteur ; A. MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; A. SMARAGDI, Auteur ; K. GONZALEZ-MADRUGA, Auteur ; A. WELLS, Auteur ; J. C. ROGERS, Auteur ; R. PAULI, Auteur ; R. CLANTON, Auteur ; R. BAKER, Auteur ; L. KERSTEN, Auteur ; M. PRÄTZLICH, Auteur ; H. OLDENHOF, Auteur ; L. JANSEN, Auteur ; A. KLEEVEN, Auteur ; Aitana BIGORRA, Auteur ; A. HERVAS, Auteur ; I. KEREXETA-LIZEAGA, Auteur ; E. SESMA-PARDO, Auteur ; M. ANGEL GONZALEZ-TORRES, Auteur ; R. SIKLÓSI, Auteur ; R. DOCHNAL, Auteur ; Z. KALOGERAKIS, Auteur ; M. PIRLYMPOU, Auteur ; L. PAPADAKOS, Auteur ; H. CORNWELL, Auteur ; W. SCHARKE, Auteur ; Dimitris DIKEOS, Auteur ; A. FERNÁNDEZ-RIVAS, Auteur ; A. POPMA, Auteur ; C. STADLER, Auteur ; B. HERPERTZ-DAHLMANN, Auteur ; Stephane A. DE BRITO, Auteur ; G. FAIRCHILD, Auteur ; C. M. FREITAG, Auteur . - p.218-228.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-2 (February 2022) . - p.218-228
Mots-clés : Conduct disorder callous-unemotional traits psychiatric comorbidity sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Conduct disorder (CD) rarely occurs alone but is typically accompanied by comorbid psychiatric disorders, which complicates the clinical presentation and treatment of affected youths. The aim of this study was to investigate sex differences in comorbidity pattern in CD and to systematically explore the 'gender paradox' and 'delayed-onset pathway' hypotheses of female CD. METHODS: As part of the FemNAT-CD multisite study, semistructured clinical interviews and rating scales were used to perform a comprehensive phenotypic characterization of 454 girls and 295 boys with CD (9-18?years), compared to 864 sex- and age-matched typically developing controls. RESULTS: Girls with CD exhibited higher rates of current major depression, anxiety disorders, post-traumatic stress disorder and borderline personality disorder, whereas boys with CD had higher rates of current attention-deficit/hyperactivity disorder. In line with the 'gender paradox' hypothesis, relative to boys, girls with CD showed significantly more lifetime psychiatric comorbidities (incl. Alcohol Use Disorder), which were accompanied by more severe CD symptoms. Female and male youths with CD also differed significantly in their CD symptom profiles and distribution of age-of-onset subtypes of CD (i.e. fewer girls with childhood-onset CD). In line with the 'delayed-onset pathway' hypothesis, girls with adolescent-onset CD showed similar levels of dimensional psychopathology like boys with childhood-onset CD, while boys with adolescent-onset CD had the lowest levels of internalizing psychopathology. CONCLUSIONS: Within the largest study of CD in girls performed to date, we found compelling evidence for sex differences in comorbidity patterns and clinical presentation of CD. Our findings further support aspects of the 'gender paradox' and 'delayed-onset pathway' hypotheses by showing that girls with CD had higher rates of comorbid lifetime mental disorders and functional impairments, and they usually developed CD during adolescence. These novel data on sex-specific clinical profiles of CD will be critical in informing intervention and prevention programmes. En ligne : http://dx.doi.org/10.1111/jcpp.13428 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457