Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach / Stelios GEORGIADES in Journal of Child Psychology and Psychiatry, 54-2 (February 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.206-215 Titre : Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach Type de document : Texte imprimé et/ou numérique Auteurs : Stelios GEORGIADES, Auteur ; Peter SZATMARI, Auteur ; Michael H. BOYLE, Auteur ; Steven HANNA, Auteur ; Eric DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Pat MIRENDA, Auteur ; Isabel M. SMITH, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Teresa BENNETT, Auteur ; Ann THOMPSON, Auteur ; PATHWAYS IN A. S. D. STUDY TEAM, Auteur Année de publication : 2013 Article en page(s) : p.206-215 Langues : Anglais (eng) Mots-clés : Symptomatology  Autistic disorder  Classification  Diagnosis  DSM Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which is often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On the basis of empirical evidence, instead of three binary categories, the upcoming edition of the DSM 5 will use two dimensions – social communication deficits (SCD) and fixated interests and repetitive behaviors (FIRB) – for the ASD diagnostic criteria. Building on this proposed DSM 5 model, it would be useful to consider whether empirical data on the SCD and FIRB dimensions can be used within the novel methodological framework of Factor Mixture Modeling (FMM) to stratify children with ASD into more homogeneous subgroups. Methods: The study sample consisted of 391 newly diagnosed children (mean age 38.3 months; 330 males) with ASD. To derive subgroups, data from the Autism Diagnostic Interview-Revised indexing SCD and FIRB were used in FMM; FMM allows the examination of continuous dimensions and latent classes (i.e., categories) using both factor analysis (FA) and latent class analysis (LCA) as part of a single analytic framework. Results: Competing LCA, FA, and FMM models were fit to the data. On the basis of a set of goodness-of-fit criteria, a ‘two-factor/three-class' factor mixture model provided the overall best fit to the data. This model describes ASD using three subgroups/classes (Class 1: 34%, Class 2: 10%, Class 3: 56% of the sample) based on differential severity gradients on the SCD and FIRB symptom dimensions. In addition to having different symptom severity levels, children from these subgroups were diagnosed at different ages and were functioning at different adaptive, language, and cognitive levels. Conclusions: Study findings suggest that the two symptom dimensions of SCD and FIRB proposed for the DSM 5 can be used in FMM to stratify children with ASD empirically into three relatively homogeneous subgroups. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02588.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188 [article] Investigating phenotypic heterogeneity in children with autism spectrum disorder: a factor mixture modeling approach [Texte imprimé et/ou numérique] / Stelios GEORGIADES, Auteur ; Peter SZATMARI, Auteur ; Michael H. BOYLE, Auteur ; Steven HANNA, Auteur ; Eric DUKU, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Joanne VOLDEN, Auteur ; Pat MIRENDA, Auteur ; Isabel M. SMITH, Auteur ; Wendy ROBERTS, Auteur ; Tracy VAILLANCOURT, Auteur ; Charlotte WADDELL, Auteur ; Teresa BENNETT, Auteur ; Ann THOMPSON, Auteur ; PATHWAYS IN A. S. D. STUDY TEAM, Auteur . - 2013 . - p.206-215. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-2 (February 2013) . - p.206-215 Mots-clés : Symptomatology  Autistic disorder  Classification  Diagnosis  DSM Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is characterized by notable phenotypic heterogeneity, which is often viewed as an obstacle to the study of its etiology, diagnosis, treatment, and prognosis. On the basis of empirical evidence, instead of three binary categories, the upcoming edition of the DSM 5 will use two dimensions – social communication deficits (SCD) and fixated interests and repetitive behaviors (FIRB) – for the ASD diagnostic criteria. Building on this proposed DSM 5 model, it would be useful to consider whether empirical data on the SCD and FIRB dimensions can be used within the novel methodological framework of Factor Mixture Modeling (FMM) to stratify children with ASD into more homogeneous subgroups. Methods: The study sample consisted of 391 newly diagnosed children (mean age 38.3 months; 330 males) with ASD. To derive subgroups, data from the Autism Diagnostic Interview-Revised indexing SCD and FIRB were used in FMM; FMM allows the examination of continuous dimensions and latent classes (i.e., categories) using both factor analysis (FA) and latent class analysis (LCA) as part of a single analytic framework. Results: Competing LCA, FA, and FMM models were fit to the data. On the basis of a set of goodness-of-fit criteria, a ‘two-factor/three-class' factor mixture model provided the overall best fit to the data. This model describes ASD using three subgroups/classes (Class 1: 34%, Class 2: 10%, Class 3: 56% of the sample) based on differential severity gradients on the SCD and FIRB symptom dimensions. In addition to having different symptom severity levels, children from these subgroups were diagnosed at different ages and were functioning at different adaptive, language, and cognitive levels. Conclusions: Study findings suggest that the two symptom dimensions of SCD and FIRB proposed for the DSM 5 can be used in FMM to stratify children with ASD empirically into three relatively homogeneous subgroups. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02588.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=188

Investigating the Measurement Properties of the Social Responsiveness Scale in Preschool Children with Autism Spectrum Disorders / Eric DUKU in Journal of Autism and Developmental Disorders, 43-4 (April 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-4 (April 2013) . - p.860-868 Titre : Investigating the Measurement Properties of the Social Responsiveness Scale in Preschool Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Eric DUKU, Auteur ; Tracy VAILLANCOURT, Auteur ; Peter SZATMARI, Auteur ; Stelios GEORGIADES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Isabel M. SMITH, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Pat MIRENDA, Auteur ; Wendy ROBERTS, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Ann THOMPSON, Auteur ; Teresa BENNETT, Auteur Article en page(s) : p.860-868 Langues : Anglais (eng) Mots-clés : Social Responsiveness Scale  Autism spectrum disorders  Measurement  Confirmatory factor analysis  Rasch analyses  Structural equation modelling Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine the measurement properties of the Social Responsiveness Scale in an accelerated longitudinal sample of 4-year-old preschool children with the complementary approaches of categorical confirmatory factor analysis and Rasch analysis. Measurement models based on the literature and other hypothesized measurement models which were tested using categorical confirmatory factor analysis did not fit well and were not unidimensional. Rasch analyses showed that a 30-item subset met criteria of unidimensionality and invariance across item, person, and over time; and this subset exhibited convergent validity with other child outcomes. This subset was shown to have enhanced psychometric properties and could be used in measuring social responsiveness among preschool age children with Autism Spectrum Disorders. En ligne : http://dx.doi.org/10.1007/s10803-012-1627-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Investigating the Measurement Properties of the Social Responsiveness Scale in Preschool Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Eric DUKU, Auteur ; Tracy VAILLANCOURT, Auteur ; Peter SZATMARI, Auteur ; Stelios GEORGIADES, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Isabel M. SMITH, Auteur ; Susan E. BRYSON, Auteur ; Eric FOMBONNE, Auteur ; Pat MIRENDA, Auteur ; Wendy ROBERTS, Auteur ; Joanne VOLDEN, Auteur ; Charlotte WADDELL, Auteur ; Ann THOMPSON, Auteur ; Teresa BENNETT, Auteur . - p.860-868. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-4 (April 2013) . - p.860-868 Mots-clés : Social Responsiveness Scale  Autism spectrum disorders  Measurement  Confirmatory factor analysis  Rasch analyses  Structural equation modelling Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine the measurement properties of the Social Responsiveness Scale in an accelerated longitudinal sample of 4-year-old preschool children with the complementary approaches of categorical confirmatory factor analysis and Rasch analysis. Measurement models based on the literature and other hypothesized measurement models which were tested using categorical confirmatory factor analysis did not fit well and were not unidimensional. Rasch analyses showed that a 30-item subset met criteria of unidimensionality and invariance across item, person, and over time; and this subset exhibited convergent validity with other child outcomes. This subset was shown to have enhanced psychometric properties and could be used in measuring social responsiveness among preschool age children with Autism Spectrum Disorders. En ligne : http://dx.doi.org/10.1007/s10803-012-1627-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Joint trajectories of internalizing and externalizing problems in preschool children with autism spectrum disorder / Tracy VAILLANCOURT in Development and Psychopathology, 29-1 (February 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-1 (February 2017) . - p.203-214 Titre : Joint trajectories of internalizing and externalizing problems in preschool children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tracy VAILLANCOURT, Auteur ; John D. HALTIGAN, Auteur ; Isabel SMITH, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; Eric FOMBONNE, Auteur ; Charlotte WADDELL, Auteur ; Eric DUKU, Auteur ; Pat MIRENDA, Auteur ; Stelios GEORGIADES, Auteur ; Teresa BENNETT, Auteur ; Joanne VOLDEN, Auteur ; Mayada ELSABBAGH, Auteur ; Wendy ROBERTS, Auteur ; Susan E. BRYSON, Auteur Article en page(s) : p.203-214 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : AbstractThe co-occurring development of internalizing and externalizing problems were examined in an inception cohort of 392 children diagnosed with autism spectrum disorder at age 3 who were assessed on four occasions. Results indicated that internalizing and externalizing problems were stable over time and highly comorbid. Joint trajectory analysis suggested that 13% of the sample followed a dual high-risk trajectory. High risk was not found to be associated with intellectual ability or autism spectrum disorder symptom severity but was linked to lower income and gender: more girls than boys were found in the high/stable internalizing problems trajectory. The results suggest that 1 in 4 preschoolers followed a trajectory of internalizing or externalizing problems (or a combination of the two) that could be characterized as clinically elevated. En ligne : http://dx.doi.org/10.1017/s0954579416000043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Joint trajectories of internalizing and externalizing problems in preschool children with autism spectrum disorder [Texte imprimé et/ou numérique] / Tracy VAILLANCOURT, Auteur ; John D. HALTIGAN, Auteur ; Isabel SMITH, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; Eric FOMBONNE, Auteur ; Charlotte WADDELL, Auteur ; Eric DUKU, Auteur ; Pat MIRENDA, Auteur ; Stelios GEORGIADES, Auteur ; Teresa BENNETT, Auteur ; Joanne VOLDEN, Auteur ; Mayada ELSABBAGH, Auteur ; Wendy ROBERTS, Auteur ; Susan E. BRYSON, Auteur . - p.203-214. Langues : Anglais (eng) in Development and Psychopathology > 29-1 (February 2017) . - p.203-214 Index. décimale : PER Périodiques Résumé : AbstractThe co-occurring development of internalizing and externalizing problems were examined in an inception cohort of 392 children diagnosed with autism spectrum disorder at age 3 who were assessed on four occasions. Results indicated that internalizing and externalizing problems were stable over time and highly comorbid. Joint trajectory analysis suggested that 13% of the sample followed a dual high-risk trajectory. High risk was not found to be associated with intellectual ability or autism spectrum disorder symptom severity but was linked to lower income and gender: more girls than boys were found in the high/stable internalizing problems trajectory. The results suggest that 1 in 4 preschoolers followed a trajectory of internalizing or externalizing problems (or a combination of the two) that could be characterized as clinically elevated. En ligne : http://dx.doi.org/10.1017/s0954579416000043 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

De Kanner au DSM-5... / Eric FOMBONNE in Bulletin Scientifique de l'arapi (Le), 28 (Décembre 2011)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 28 (Décembre 2011) . - p.10-11 Titre : De Kanner au DSM-5... Type de document : Texte imprimé et/ou numérique Auteurs : Eric FOMBONNE, Auteur Année de publication : 2011 Article en page(s) : p.10-11 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] De Kanner au DSM-5... [Texte imprimé et/ou numérique] / Eric FOMBONNE, Auteur . - 2011 . - p.10-11. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 28 (Décembre 2011) . - p.10-11 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Mobile and online consumer tools to screen for autism do not promote equity / Benjamin W SANDERS in Autism, 27-3 (April 2023)  

Public ISBD [article]  inAutism > 27-3 (April 2023) . - p.714-722 Titre : Mobile and online consumer tools to screen for autism do not promote equity Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin W SANDERS, Auteur ; Steven BEDRICK, Auteur ; Sarabeth BRODER-FINGERT, Auteur ; Shannon A BROWN, Auteur ; Jill K DOLATA, Auteur ; Eric FOMBONNE, Auteur ; Julie A REEDER, Auteur ; Luis Andres RIVAS VAZQUEZ, Auteur ; Plyce FUCHU, Auteur ; Yesenia MORALES, Auteur ; Katharine E ZUCKERMAN, Auteur Article en page(s) : p.714-722 Langues : Anglais (eng) Mots-clés : autism spectrum disorder,digital divide,mass screening,mobile applications,parents,preschool,child Index. décimale : PER Périodiques Résumé : Limited access to screening and evaluation for autism spectrum disorder in children is a major barrier to improving outcomes for marginalized families. To identify and evaluate available digital autism spectrum disorder screening resources, we simulated web and mobile app searches by a parent concerned about their child?s likelihood of autism spectrum disorder. Included digital autism spectrum disorder screening tools (a) were on Internet or mobile app; (b) were in English; (c) had a parent user inputting data; (d) assigned likelihood category to child <9?years; and (e) screened for autism spectrum disorder. Ten search terms, developed using Google Search and parent panel recommendations, were used to search web and app tools in the United States, the United Kingdom, India, Australia, and Canada using Virtual Private Networks. Results were examined for attributes likely to benefit parents in marginalized communities, such as ease of searching, language versions, and reading level. The four terms most likely to identify any tools were ''autism quiz,'' ''autism screening tool,'' ''does my child have autism,'' and ''autism toddler.'' Three out of five searches contained autism spectrum disorder screening tools, as did one of 10 links or apps. Searches identified a total of 1475 websites and 919 apps, which yielded 23 unique tools. Most tools required continuous Internet access or offered only English, and many had high reading levels. In conclusion, screening tools are available, but they are not easily found. Barriers include inaccessibility to parents with limited literacy or limited English proficiency, and frequent encounters with games, advertisements, and user fees.Lay AbstractMany parents wonder if their child might have autism. Many parents use their smartphones to answer health questions. We asked, ''How easy or hard is it for parents to use their smartphones to find 'tools' to test their child for signs of autism?'' After doing pretend parent searches, we found that only one in 10 search results were tools to test children for autism. These tools were not designed for parents who have low income or other challenges such as low literacy skills, low English proficiency, or not being tech-savvy. En ligne : https://doi.org/10.1177/13623613221114280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Mobile and online consumer tools to screen for autism do not promote equity [Texte imprimé et/ou numérique] / Benjamin W SANDERS, Auteur ; Steven BEDRICK, Auteur ; Sarabeth BRODER-FINGERT, Auteur ; Shannon A BROWN, Auteur ; Jill K DOLATA, Auteur ; Eric FOMBONNE, Auteur ; Julie A REEDER, Auteur ; Luis Andres RIVAS VAZQUEZ, Auteur ; Plyce FUCHU, Auteur ; Yesenia MORALES, Auteur ; Katharine E ZUCKERMAN, Auteur . - p.714-722. Langues : Anglais (eng) in Autism > 27-3 (April 2023) . - p.714-722 Mots-clés : autism spectrum disorder,digital divide,mass screening,mobile applications,parents,preschool,child Index. décimale : PER Périodiques Résumé : Limited access to screening and evaluation for autism spectrum disorder in children is a major barrier to improving outcomes for marginalized families. To identify and evaluate available digital autism spectrum disorder screening resources, we simulated web and mobile app searches by a parent concerned about their child?s likelihood of autism spectrum disorder. Included digital autism spectrum disorder screening tools (a) were on Internet or mobile app; (b) were in English; (c) had a parent user inputting data; (d) assigned likelihood category to child <9?years; and (e) screened for autism spectrum disorder. Ten search terms, developed using Google Search and parent panel recommendations, were used to search web and app tools in the United States, the United Kingdom, India, Australia, and Canada using Virtual Private Networks. Results were examined for attributes likely to benefit parents in marginalized communities, such as ease of searching, language versions, and reading level. The four terms most likely to identify any tools were ''autism quiz,'' ''autism screening tool,'' ''does my child have autism,'' and ''autism toddler.'' Three out of five searches contained autism spectrum disorder screening tools, as did one of 10 links or apps. Searches identified a total of 1475 websites and 919 apps, which yielded 23 unique tools. Most tools required continuous Internet access or offered only English, and many had high reading levels. In conclusion, screening tools are available, but they are not easily found. Barriers include inaccessibility to parents with limited literacy or limited English proficiency, and frequent encounters with games, advertisements, and user fees.Lay AbstractMany parents wonder if their child might have autism. Many parents use their smartphones to answer health questions. We asked, ''How easy or hard is it for parents to use their smartphones to find 'tools' to test their child for signs of autism?'' After doing pretend parent searches, we found that only one in 10 search results were tools to test children for autism. These tools were not designed for parents who have low income or other challenges such as low literacy skills, low English proficiency, or not being tech-savvy. En ligne : https://doi.org/10.1177/13623613221114280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

Modeling the Phenotypic Architecture of Autism Symptoms from Time of Diagnosis to Age 6 / Stelios GEORGIADES in Journal of Autism and Developmental Disorders, 44-12 (December 2014)  

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Modest Impact on Risk for Autism Spectrum Disorder of Rare Copy Number Variants at 15q11.2, Specifically Breakpoints 1 to 2 / Pauline CHASTE in Autism Research, 7-3 (June 2014)  

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No Sex Differences in Cognitive Ability in Young Children with Autism Spectrum Disorder / Susanne W. DUVALL in Journal of Autism and Developmental Disorders, 50-5 (May 2020)  

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Overweight and Obesity: Prevalence and Correlates in a Large Clinical Sample of Children with Autism Spectrum Disorder / Katharine E. ZUCKERMAN in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

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Perception of emotion in musical performance in adolescents with autism spectrum disorders / Anjali BHATARA in Autism Research, 3-5 (October 2010)  

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Phenotypic Overlap Between Core Diagnostic Features and Emotional/Behavioral Problems in Preschool Children with Autism Spectrum Disorder / Stelios GEORGIADES in Journal of Autism and Developmental Disorders, 41-10 (October 2011)  

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La position de l'autisme et des psychoses infantiles dans plusieurs nosographies / Eric FOMBONNE in Handicap et Inadaptations, 57 (janvier-mars 1992)

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Pragmatic language markers of autism diagnosis and severity / Jill K. DOLATA in Research in Autism Spectrum Disorders, 94 (June 2022)  

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Prevalence and Incidence of Autism Spectrum Disorder in an Israeli Population / Michael DAVIDOVITCH in Journal of Autism and Developmental Disorders, 43-4 (April 2013)  

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Prévalence de l’autisme infantile dans quatre régions françaises / Eric FOMBONNE in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., HS 3-4 (Novembre 1997)

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