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Auteur J. YANG |
Documents disponibles écrits par cet auteur (2)
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Genome-wide association study and identification of chromosomal enhancer maps in multiple brain regions related to autism spectrum disorder / L. ZHANG in Autism Research, 12-1 (January 2019)
[article]
Titre : Genome-wide association study and identification of chromosomal enhancer maps in multiple brain regions related to autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. ZHANG, Auteur ; L. LIU, Auteur ; Y. WEN, Auteur ; M. MA, Auteur ; S. CHENG, Auteur ; J. YANG, Auteur ; P. LI, Auteur ; B. CHENG, Auteur ; Y. DU, Auteur ; X. LIANG, Auteur ; Y. ZHAO, Auteur ; M. DING, Auteur ; X. GUO, Auteur ; F. ZHANG, Auteur Article en page(s) : p.26-32 Langues : Anglais (eng) Mots-clés : autism biological pathways brain regions enhancer Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex developmental disorder with strong genetic components involved. Recent studies have demonstrated the importance of non-coding regulatory variants for complex diseases. To explore the roles of chromosomal enhancer regions in the pathogenesis of ASD, we conducted an integrative analysis of genome-wide association study (GWAS) and brain region related enhancer-gene networks for ASD. The GWAS data of ASD were driven from a published study, involving 7,387 ASD cases and 8,567 controls. The enhancer-gene networks of eight brain regions were used here. The GWAS of ASD was first merged respectively with the enhancer datasets of eight brain regions. Pathway enrichment analysis was then performed to detect ASD associated pathways based on the enhancer-related single nucleotide polymorphism (SNPs) of each brain region. We detected multiple genes with brain region specific or common association signals, such as PGM3 (P value = 1.93 x 10(-5) ) and RWDD2A (P value = 1.93 x 10(-5) ) for hippocampus middle, and ENPP4 (all P values <0.05), and ENPP5 (all P values <0.05) for seven brain regions. By comparing the pathway enrichment analysis results of various brain regions, several cross brain regions pathways were detected for ASD, such as REACTOME_POTASSIUM_CHANNELS (all P values <0.05) for six brain regions and KEGG_CELL_ADHESION_MOLECULES_CAMS (all P values <0.05) for seven brain regions. In addition, several pathways were also identified for specific brain regions, such as REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING (P value = 4.00 x 10(-3) ) for angular gyrus, REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR (P value = 2.22 x 10(-3) ) for anterior caudate, and KEGG_PRION_DISEASES (P value = 1.00 x 10(-4) ) for germinal matrix. Our results provide novel clues for understanding the genetic basis of ASD. Autism Research 2019, 12: 26-32. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: ASD is a complex developmental disorder with strong genetic components, but the pathogenesis of ASD is still unclear. Using the latest GWAS data and enhancer map, we explored the brain region related biological pathways associated with ASD. Our results provide novel clues for revealing the functional relevance of enhancer variants with ASD and understanding the genetic basis of ASD. En ligne : http://dx.doi.org/10.1002/aur.2001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Autism Research > 12-1 (January 2019) . - p.26-32[article] Genome-wide association study and identification of chromosomal enhancer maps in multiple brain regions related to autism spectrum disorder [Texte imprimé et/ou numérique] / L. ZHANG, Auteur ; L. LIU, Auteur ; Y. WEN, Auteur ; M. MA, Auteur ; S. CHENG, Auteur ; J. YANG, Auteur ; P. LI, Auteur ; B. CHENG, Auteur ; Y. DU, Auteur ; X. LIANG, Auteur ; Y. ZHAO, Auteur ; M. DING, Auteur ; X. GUO, Auteur ; F. ZHANG, Auteur . - p.26-32.
Langues : Anglais (eng)
in Autism Research > 12-1 (January 2019) . - p.26-32
Mots-clés : autism biological pathways brain regions enhancer Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex developmental disorder with strong genetic components involved. Recent studies have demonstrated the importance of non-coding regulatory variants for complex diseases. To explore the roles of chromosomal enhancer regions in the pathogenesis of ASD, we conducted an integrative analysis of genome-wide association study (GWAS) and brain region related enhancer-gene networks for ASD. The GWAS data of ASD were driven from a published study, involving 7,387 ASD cases and 8,567 controls. The enhancer-gene networks of eight brain regions were used here. The GWAS of ASD was first merged respectively with the enhancer datasets of eight brain regions. Pathway enrichment analysis was then performed to detect ASD associated pathways based on the enhancer-related single nucleotide polymorphism (SNPs) of each brain region. We detected multiple genes with brain region specific or common association signals, such as PGM3 (P value = 1.93 x 10(-5) ) and RWDD2A (P value = 1.93 x 10(-5) ) for hippocampus middle, and ENPP4 (all P values <0.05), and ENPP5 (all P values <0.05) for seven brain regions. By comparing the pathway enrichment analysis results of various brain regions, several cross brain regions pathways were detected for ASD, such as REACTOME_POTASSIUM_CHANNELS (all P values <0.05) for six brain regions and KEGG_CELL_ADHESION_MOLECULES_CAMS (all P values <0.05) for seven brain regions. In addition, several pathways were also identified for specific brain regions, such as REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING (P value = 4.00 x 10(-3) ) for angular gyrus, REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR (P value = 2.22 x 10(-3) ) for anterior caudate, and KEGG_PRION_DISEASES (P value = 1.00 x 10(-4) ) for germinal matrix. Our results provide novel clues for understanding the genetic basis of ASD. Autism Research 2019, 12: 26-32. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: ASD is a complex developmental disorder with strong genetic components, but the pathogenesis of ASD is still unclear. Using the latest GWAS data and enhancer map, we explored the brain region related biological pathways associated with ASD. Our results provide novel clues for revealing the functional relevance of enhancer variants with ASD and understanding the genetic basis of ASD. En ligne : http://dx.doi.org/10.1002/aur.2001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice / X. WANG in Autism Research, 12-4 (April 2019)
[article]
Titre : Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice Type de document : Texte imprimé et/ou numérique Auteurs : X. WANG, Auteur ; J. YANG, Auteur ; H. ZHANG, Auteur ; J. YU, Auteur ; Z. YAO, Auteur Article en page(s) : p.576-588 Langues : Anglais (eng) Mots-clés : anti-inflammation autism spectrum disorders interleukin 17a interleukin 6 maternal immune activation probiotics Index. décimale : PER Périodiques Résumé : Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL-6) and IL-17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD-like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA-induced increases in the IL-6 and IL-17a levels in both maternal serum and fetal brains, parvalbumin positive (PV(+) ) neuron loss, and the decrease in the gamma-aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. Autism Res 2019, 12: 576-588. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Interleukin 6 (IL-6) and IL-17a are key cytokines in the maternal immune activation (MIA)-induced autism spectrum disorders (ASD). Based on emerging evidence that probiotics can inhibit the production of proinflammatory cytokines, we found that oral probiotics prevented MIA-induced ASD-like behaviors in offspring. This work suggested that oral probiotics during pregnancy may be an effective means for decreasing the incidence of ASD in offspring. En ligne : https://dx.doi.org/10.1002/aur.2079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388
in Autism Research > 12-4 (April 2019) . - p.576-588[article] Oral probiotic administration during pregnancy prevents autism-related behaviors in offspring induced by maternal immune activation via anti-inflammation in mice [Texte imprimé et/ou numérique] / X. WANG, Auteur ; J. YANG, Auteur ; H. ZHANG, Auteur ; J. YU, Auteur ; Z. YAO, Auteur . - p.576-588.
Langues : Anglais (eng)
in Autism Research > 12-4 (April 2019) . - p.576-588
Mots-clés : anti-inflammation autism spectrum disorders interleukin 17a interleukin 6 maternal immune activation probiotics Index. décimale : PER Périodiques Résumé : Maternal immune activation (MIA) is associated with an increased risk for autism spectrum disorders (ASD) in offspring. Animal experiments have found that interleukin 6 (IL-6) and IL-17a are key cytokines in the induction of ASD by MIA. Moreover, probiotics were verified to inhibit the production of proinflammatory cytokines. Therefore, we investigated whether the administration of oral probiotics during pregnancy might protect the offspring that have suffered MIA from developing ASD. Probiotics were orally administered to pregnant mice with/without the simultaneous administration of Poly(I:C). We found that oral probiotics prevented the ASD-like behaviors induced by MIA in offspring. Furthermore, oral probiotics prevented the MIA-induced increases in the IL-6 and IL-17a levels in both maternal serum and fetal brains, parvalbumin positive (PV(+) ) neuron loss, and the decrease in the gamma-aminobutyric acid levels in the prefrontal cortex of adult offspring. This work suggests that administering oral probiotics during pregnancy may help decrease the risk of ASD following MIA during pregnancy. Autism Res 2019, 12: 576-588. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Interleukin 6 (IL-6) and IL-17a are key cytokines in the maternal immune activation (MIA)-induced autism spectrum disorders (ASD). Based on emerging evidence that probiotics can inhibit the production of proinflammatory cytokines, we found that oral probiotics prevented MIA-induced ASD-like behaviors in offspring. This work suggested that oral probiotics during pregnancy may be an effective means for decreasing the incidence of ASD in offspring. En ligne : https://dx.doi.org/10.1002/aur.2079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388