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Détail de l'auteur
Auteur J. P. NEWNHAM |
Documents disponibles écrits par cet auteur (1)
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Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population / Kandice J. VARCIN in Autism Research, 12-1 (January 2019)
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Titre : Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population Type de document : Texte imprimé et/ou numérique Auteurs : Kandice J. VARCIN, Auteur ; J. P. NEWNHAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.80-88 Langues : Anglais (eng) Mots-clés : autism spectrum disorder body mass index maternal obesity prenatal Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence demonstrating that maternal obesity at the time of conception increases the risk for Autism Spectrum Disorders (ASD) among offspring. We explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. A large sample of women, recruited during the second trimester of pregnancy, had their height measured and reported their pre-pregnancy weight. These measurements were then converted to a Body Mass Index (BMI) using the formula: (weight in kilograms)/(height in metres(2) ). At 19-20 years of age, 1238 offspring of these women completed a measure of autistic-like traits, the Autism-Spectrum Quotient (AQ). Regression analyses identified a positive association between increasing maternal pre-pregnancy BMI and increasing AQ Total Score amongst offspring; this association was maintained even after controlling for a range of variables including maternal/obstetric factors (age at conception, education, smoking, alcohol consumption, hypertensive diseases, diabetes, threatened abortion), paternal BMI at pregnancy, and child factors (parity, sex) (P < .01, R(2) =.03). Chi-square analyses found that women with pre-pregnancy obesity (BMI >/= 30) were more likely to have offspring with high scores (>/=26) on the AQ (P = .01). Follow-up binary logistic regression analyses also accounting for the same obstetric and sociodemographic variables found that the offspring of women with pre-pregnancy obesity were at a statistically significantly increased risk of having high scores (>/=26) on the AQ (OR: 2.80; 95% CI: 1.06, 7.43). This study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring. Autism Research 2019, 12: 80-88. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The current study explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. We found that pre-pregnancy body mass index in women is associated with the amount of autistic-like traits in their children in early adulthood. Specifically, women who were obese at the time of conception were more likely to have a child who had high levels of autistic-like traits in early adulthood. En ligne : http://dx.doi.org/10.1002/aur.1973 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376
in Autism Research > 12-1 (January 2019) . - p.80-88[article] Maternal pre-pregnancy weight and autistic-like traits among offspring in the general population [Texte imprimé et/ou numérique] / Kandice J. VARCIN, Auteur ; J. P. NEWNHAM, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.80-88.
Langues : Anglais (eng)
in Autism Research > 12-1 (January 2019) . - p.80-88
Mots-clés : autism spectrum disorder body mass index maternal obesity prenatal Index. décimale : PER Périodiques Résumé : There is an emerging body of evidence demonstrating that maternal obesity at the time of conception increases the risk for Autism Spectrum Disorders (ASD) among offspring. We explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. A large sample of women, recruited during the second trimester of pregnancy, had their height measured and reported their pre-pregnancy weight. These measurements were then converted to a Body Mass Index (BMI) using the formula: (weight in kilograms)/(height in metres(2) ). At 19-20 years of age, 1238 offspring of these women completed a measure of autistic-like traits, the Autism-Spectrum Quotient (AQ). Regression analyses identified a positive association between increasing maternal pre-pregnancy BMI and increasing AQ Total Score amongst offspring; this association was maintained even after controlling for a range of variables including maternal/obstetric factors (age at conception, education, smoking, alcohol consumption, hypertensive diseases, diabetes, threatened abortion), paternal BMI at pregnancy, and child factors (parity, sex) (P < .01, R(2) =.03). Chi-square analyses found that women with pre-pregnancy obesity (BMI >/= 30) were more likely to have offspring with high scores (>/=26) on the AQ (P = .01). Follow-up binary logistic regression analyses also accounting for the same obstetric and sociodemographic variables found that the offspring of women with pre-pregnancy obesity were at a statistically significantly increased risk of having high scores (>/=26) on the AQ (OR: 2.80; 95% CI: 1.06, 7.43). This study provides further evidence that maternal pre-pregnancy obesity is associated with autism-like behaviors in offspring. Autism Research 2019, 12: 80-88. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The current study explored whether pre-pregnancy weight was related to autistic-like traits among offspring not diagnosed with ASD. We found that pre-pregnancy body mass index in women is associated with the amount of autistic-like traits in their children in early adulthood. Specifically, women who were obese at the time of conception were more likely to have a child who had high levels of autistic-like traits in early adulthood. En ligne : http://dx.doi.org/10.1002/aur.1973 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376