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Détail de l'auteur
Auteur J. Michael BOWERS |
Documents disponibles écrits par cet auteur (2)
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ASD-relevant Animal Models of the Foxp Family of Transcription Factors / J. Michael BOWERS in Autism - Open Access, 2-S ([01/12/2012])
[article]
Titre : ASD-relevant Animal Models of the Foxp Family of Transcription Factors Type de document : Texte imprimé et/ou numérique Auteurs : J. Michael BOWERS, Auteur ; Genevieve KONOPKA, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : FOXP2 FOXP1 Autism Genetics Rodent vocalization Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder with a multifaceted association between genes and the environment. Currently, in the majority of patients, the etiology of autism is not known and coupled with increasing prevalence rates, along with the high degree of heritability of autism, the development of animal models is crucial for studying and developing therapies for autism. A key characteristic of autism is marked abnormalities in the acquisition and use of language. Thus, to understand and ultimately treat autism is an especially difficult task because no animal produces language, as it is defined in humans. In this review, we will discuss the FOXP family of genes, which are a group of transcription factors that have been linked to both autism, as well as language in humans. Due to the association of language/communication and the Foxp family of transcription factors, animal models with targeted disruptions of Foxp functioning are powerful tools for understanding the developmental signaling pathways that may be vulnerable in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409
in Autism - Open Access > 2-S [01/12/2012] . - 7 p.[article] ASD-relevant Animal Models of the Foxp Family of Transcription Factors [Texte imprimé et/ou numérique] / J. Michael BOWERS, Auteur ; Genevieve KONOPKA, Auteur . - 7 p.
Langues : Anglais (eng)
in Autism - Open Access > 2-S [01/12/2012] . - 7 p.
Mots-clés : FOXP2 FOXP1 Autism Genetics Rodent vocalization Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder with a multifaceted association between genes and the environment. Currently, in the majority of patients, the etiology of autism is not known and coupled with increasing prevalence rates, along with the high degree of heritability of autism, the development of animal models is crucial for studying and developing therapies for autism. A key characteristic of autism is marked abnormalities in the acquisition and use of language. Thus, to understand and ultimately treat autism is an especially difficult task because no animal produces language, as it is defined in humans. In this review, we will discuss the FOXP family of genes, which are a group of transcription factors that have been linked to both autism, as well as language in humans. Due to the association of language/communication and the Foxp family of transcription factors, animal models with targeted disruptions of Foxp functioning are powerful tools for understanding the developmental signaling pathways that may be vulnerable in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.S1-010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 Echolalia from a transdiagnostic perspective / Tyler C. MCFAYDEN in Autism & Developmental Language Impairments, 7 (January-December 2022)
[article]
Titre : Echolalia from a transdiagnostic perspective Type de document : Texte imprimé et/ou numérique Auteurs : Tyler C. MCFAYDEN, Auteur ; Shelia M. KENNISON, Auteur ; J. Michael BOWERS, Auteur Langues : Anglais (eng) Mots-clés : Echolalia aphasia autism repetitive speech transdiagnostic Index. décimale : PER Périodiques Résumé : Background & aims Echolalia, the repetition of one’s or others’ utterances, is a behavior present in typical development, autism spectrum disorder, aphasias, Tourette’s, and other clinical groups. Despite the broad range of conditions in which echolalia can occur, it is considered primarily through a disorder-specific lens, which limits a full understanding of the behavior. Method Empirical and review papers on echolalia across disciplines and etiologies were considered for this narrative review. Literatures were condensed into three primary sections, including echolalia presentations, neural mechanisms, and treatment approaches. Main contribution Echolalia, commonly observed in autism and other developmental conditions, is assessed, observed, and treated in a siloed fashion, which reduces our collective knowledge of this communication difference. Echolalia should be considered as a developmental, transdiagnostic, and communicative phenomenon. Echolalia is commonly considered as a communicative behavior, but little is known about its neural etiologies or efficacious treatments. Conclusions This review is the first to synthesize echolalia from a transdiagnostic perspective, which allows for the direct comparisons across and within clinical groups to inform assessment, treatment, conceptualization, and research recommendations. Implications Considering echolalia transdiagnostically highlights the lack of consensus on operationalization and measurement across and within disorders. Clinical and research future directions need to prioritize consistent definitions of echolalia, which can be used to derive accurate prevalence estimates. Echolalia should be considered as a communication strategy, used similarly across developmental and clinical groups, with recommended strategies of shaping to increase its effectiveness. En ligne : http://dx.doi.org/10.1177/23969415221140464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491
in Autism & Developmental Language Impairments > 7 (January-December 2022)[article] Echolalia from a transdiagnostic perspective [Texte imprimé et/ou numérique] / Tyler C. MCFAYDEN, Auteur ; Shelia M. KENNISON, Auteur ; J. Michael BOWERS, Auteur.
Langues : Anglais (eng)
in Autism & Developmental Language Impairments > 7 (January-December 2022)
Mots-clés : Echolalia aphasia autism repetitive speech transdiagnostic Index. décimale : PER Périodiques Résumé : Background & aims Echolalia, the repetition of one’s or others’ utterances, is a behavior present in typical development, autism spectrum disorder, aphasias, Tourette’s, and other clinical groups. Despite the broad range of conditions in which echolalia can occur, it is considered primarily through a disorder-specific lens, which limits a full understanding of the behavior. Method Empirical and review papers on echolalia across disciplines and etiologies were considered for this narrative review. Literatures were condensed into three primary sections, including echolalia presentations, neural mechanisms, and treatment approaches. Main contribution Echolalia, commonly observed in autism and other developmental conditions, is assessed, observed, and treated in a siloed fashion, which reduces our collective knowledge of this communication difference. Echolalia should be considered as a developmental, transdiagnostic, and communicative phenomenon. Echolalia is commonly considered as a communicative behavior, but little is known about its neural etiologies or efficacious treatments. Conclusions This review is the first to synthesize echolalia from a transdiagnostic perspective, which allows for the direct comparisons across and within clinical groups to inform assessment, treatment, conceptualization, and research recommendations. Implications Considering echolalia transdiagnostically highlights the lack of consensus on operationalization and measurement across and within disorders. Clinical and research future directions need to prioritize consistent definitions of echolalia, which can be used to derive accurate prevalence estimates. Echolalia should be considered as a communication strategy, used similarly across developmental and clinical groups, with recommended strategies of shaping to increase its effectiveness. En ligne : http://dx.doi.org/10.1177/23969415221140464 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491