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Détail de l'auteur
Auteur Michael A. MOONEY |
Documents disponibles écrits par cet auteur (1)
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Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD / Joel T. NIGG in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)
[article]
Titre : Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Joel T. NIGG, Auteur ; Sarah L. KARALUNAS, Auteur ; Hanna C. GUSTAFSSON, Auteur ; Priya BHATT, Auteur ; Peter RYABININ, Auteur ; Michael A. MOONEY, Auteur ; Stephen V. FARAONE, Auteur ; Damien A. FAIR, Auteur ; Beth WILMOT, Auteur Article en page(s) : p.205-214 Langues : Anglais (eng) Mots-clés : Adhd irritability polygenic score temperament Index. décimale : PER Périodiques Résumé : BACKGROUND: A central nosological problem concerns the etiological relationship of emotional dysregulation with ADHD. Molecular genetic risk scores provide a novel method for informing this question. METHODS: Participants were 514 community-recruited children of Northern European descent age 7-11 defined as ADHD or non-ADHD by detailed research evaluation. Parents-rated ADHD on standardized ratings and child temperament on the Temperament in Middle Childhood Questionnaire (TMCQ) and reported on ADHD and comorbid disorders by semi-structured clinical interview. Categorical and dimensional variables were created for ADHD, emotional dysregulation (implicating disruption of regulation of both anger-irritability and of positive valence surgency-sensation seeking), and irritability alone (anger dysregulation). Genome-wide polygenic risk scores (PRS) were computed for ADHD and depression genetic liability. Structural equation models and computationally derived emotion profiles guided analysis. RESULTS: The ADHD PRS was associated in variable-centered analyses with irritability (beta = .179, 95% CI = 0.087-0.280; DeltaR(2) = .034, p < .0002), but also with surgency/sensation seeking (B = .146, 95%CI = 0.052-0.240, DeltaR(2) =.022, p = .002). In person-centered analysis, the ADHD PRS was elevated in the emotion dysregulation ADHD group versus other ADHD children (OR = 1.44, 95% CI = 1.03-2.20, Nagelkerke DeltaR(2) = .013, p = .033) but did not differentiate irritable from surgent ADHD profiles. All effects were independent of variation in ADHD severity across traits or groups. The depression PRS was related to oppositional defiant disorder but not to ADHD emotion dysregulation. CONCLUSIONS: Irritability-anger and surgency-sensation seeking, as forms of negative and positively valenced dysregulated affect in ADHD populations, both relate principally to ADHD genetic risk and not mood-related genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415
in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.205-214[article] Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD [Texte imprimé et/ou numérique] / Joel T. NIGG, Auteur ; Sarah L. KARALUNAS, Auteur ; Hanna C. GUSTAFSSON, Auteur ; Priya BHATT, Auteur ; Peter RYABININ, Auteur ; Michael A. MOONEY, Auteur ; Stephen V. FARAONE, Auteur ; Damien A. FAIR, Auteur ; Beth WILMOT, Auteur . - p.205-214.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.205-214
Mots-clés : Adhd irritability polygenic score temperament Index. décimale : PER Périodiques Résumé : BACKGROUND: A central nosological problem concerns the etiological relationship of emotional dysregulation with ADHD. Molecular genetic risk scores provide a novel method for informing this question. METHODS: Participants were 514 community-recruited children of Northern European descent age 7-11 defined as ADHD or non-ADHD by detailed research evaluation. Parents-rated ADHD on standardized ratings and child temperament on the Temperament in Middle Childhood Questionnaire (TMCQ) and reported on ADHD and comorbid disorders by semi-structured clinical interview. Categorical and dimensional variables were created for ADHD, emotional dysregulation (implicating disruption of regulation of both anger-irritability and of positive valence surgency-sensation seeking), and irritability alone (anger dysregulation). Genome-wide polygenic risk scores (PRS) were computed for ADHD and depression genetic liability. Structural equation models and computationally derived emotion profiles guided analysis. RESULTS: The ADHD PRS was associated in variable-centered analyses with irritability (beta = .179, 95% CI = 0.087-0.280; DeltaR(2) = .034, p < .0002), but also with surgency/sensation seeking (B = .146, 95%CI = 0.052-0.240, DeltaR(2) =.022, p = .002). In person-centered analysis, the ADHD PRS was elevated in the emotion dysregulation ADHD group versus other ADHD children (OR = 1.44, 95% CI = 1.03-2.20, Nagelkerke DeltaR(2) = .013, p = .033) but did not differentiate irritable from surgent ADHD profiles. All effects were independent of variation in ADHD severity across traits or groups. The depression PRS was related to oppositional defiant disorder but not to ADHD emotion dysregulation. CONCLUSIONS: Irritability-anger and surgency-sensation seeking, as forms of negative and positively valenced dysregulated affect in ADHD populations, both relate principally to ADHD genetic risk and not mood-related genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415