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Auteur Oliver BRÜSTLE |
Documents disponibles écrits par cet auteur (1)
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Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction / Arquimedes CHEFFER in Molecular Autism, 11 (2020)
[article]
Titre : Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction Type de document : Texte imprimé et/ou numérique Auteurs : Arquimedes CHEFFER, Auteur ; Lea Jessica FLITSCH, Auteur ; Tamara KRUTENKO, Auteur ; Pascal RÖDERER, Auteur ; Liubov SOKHRANYAEVA, Auteur ; Vira IEFREMOVA, Auteur ; Mohamad HAJO, Auteur ; Michael PEITZ, Auteur ; Martin Karl SCHWARZ, Auteur ; Oliver BRÜSTLE, Auteur Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Brain organoids Cell reprogramming In vitro differentiation Induced pluripotent stem cells Neuronal connectivity Index. décimale : PER Périodiques Résumé : The controlled differentiation of pluripotent stem cells (PSCs) into neurons and glia offers a unique opportunity to study early stages of human central nervous system development under controlled conditions in vitro. With the advent of cell reprogramming and the possibility to generate induced pluripotent stem cells (iPSCs) from any individual in a scalable manner, these studies can be extended to a disease- and patient-specific level. Autism spectrum disorder (ASD) is considered a neurodevelopmental disorder, with substantial evidence pointing to early alterations in neurogenesis and network formation as key pathogenic drivers. For that reason, ASD represents an ideal candidate for stem cell-based disease modeling. Here, we provide a concise review on recent advances in the field of human iPSC-based modeling of syndromic and non-syndromic forms of ASD, with a particular focus on studies addressing neuronal dysfunction and altered connectivity. We further discuss recent efforts to translate stem cell-based disease modeling to 3D via brain organoid and cell transplantation approaches, which enable the investigation of disease mechanisms in a tissue-like context. Finally, we describe advanced tools facilitating the assessment of altered neuronal function, comment on the relevance of iPSC-based models for the assessment of pharmaceutical therapies and outline potential future routes in stem cell-based ASD research. En ligne : http://dx.doi.org/10.1186/s13229-020-00383-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438
in Molecular Autism > 11 (2020)[article] Human stem cell-based models for studying autism spectrum disorder-related neuronal dysfunction [Texte imprimé et/ou numérique] / Arquimedes CHEFFER, Auteur ; Lea Jessica FLITSCH, Auteur ; Tamara KRUTENKO, Auteur ; Pascal RÖDERER, Auteur ; Liubov SOKHRANYAEVA, Auteur ; Vira IEFREMOVA, Auteur ; Mohamad HAJO, Auteur ; Michael PEITZ, Auteur ; Martin Karl SCHWARZ, Auteur ; Oliver BRÜSTLE, Auteur.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020)
Mots-clés : Autism spectrum disorder Brain organoids Cell reprogramming In vitro differentiation Induced pluripotent stem cells Neuronal connectivity Index. décimale : PER Périodiques Résumé : The controlled differentiation of pluripotent stem cells (PSCs) into neurons and glia offers a unique opportunity to study early stages of human central nervous system development under controlled conditions in vitro. With the advent of cell reprogramming and the possibility to generate induced pluripotent stem cells (iPSCs) from any individual in a scalable manner, these studies can be extended to a disease- and patient-specific level. Autism spectrum disorder (ASD) is considered a neurodevelopmental disorder, with substantial evidence pointing to early alterations in neurogenesis and network formation as key pathogenic drivers. For that reason, ASD represents an ideal candidate for stem cell-based disease modeling. Here, we provide a concise review on recent advances in the field of human iPSC-based modeling of syndromic and non-syndromic forms of ASD, with a particular focus on studies addressing neuronal dysfunction and altered connectivity. We further discuss recent efforts to translate stem cell-based disease modeling to 3D via brain organoid and cell transplantation approaches, which enable the investigation of disease mechanisms in a tissue-like context. Finally, we describe advanced tools facilitating the assessment of altered neuronal function, comment on the relevance of iPSC-based models for the assessment of pharmaceutical therapies and outline potential future routes in stem cell-based ASD research. En ligne : http://dx.doi.org/10.1186/s13229-020-00383-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438