Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Détail de l'auteur
Auteur Abdullah BOZKURT |
Documents disponibles écrits par cet auteur (2)
Faire une suggestion Affiner la recherche
Evaluation of retinal nerve fiber layer thickness in children with autism spectrum disorders / Abdullah BOZKURT in Research in Autism Spectrum Disorders, 98 (October 2022)
[article]
Titre : Evaluation of retinal nerve fiber layer thickness in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Abdullah BOZKURT, Auteur ; Gokçe Nur SAY, Auteur ; Berkan SAHIN, Auteur ; Miraç Baris USTA, Auteur ; Merve KALYONCU, Auteur ; Nurullah KOCAK, Auteur ; Osmanli CANSU COBANOGLU, Auteur Article en page(s) : 102050 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Retinal nerve fiber layer thickness Optical coherence tomography Index. décimale : PER Périodiques Résumé : Background The study compared retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume of children with autism spectrum disorder (ASD) to those of healthy control group and correlated the RNFL thickness with symptom severity in children with ASD. Method Forty children between the ages of 7 and 12 with normal intelligence levels and who were diagnosed with ASD as per DSM-5 were included in the ASD group. The control group consisted of healthy children, who were matched with subjects in the ASD group in terms of age and gender. The Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS) were used to evaluate the severity of the disease in the cases diagnosed with ASD. The RNFL, macular thickness, and macular volume of all participants were measured optical coherence tomography (OCT). Results The temporal, temporal superior, nasal superior, temporal inferior, and global RNFL thicknesses were significantly lower in the ASD group than in the control group. There was no correlation between the RNFL thickness and ASD symptom severity. The macular thickness and volume were not significantly different between the groups. Conclusion Our data suggest that lower RNFL thickness may relate to atypical brain development in the ASD, and this can be measured in the retina. En ligne : https://doi.org/10.1016/j.rasd.2022.102050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490
in Research in Autism Spectrum Disorders > 98 (October 2022) . - 102050[article] Evaluation of retinal nerve fiber layer thickness in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Abdullah BOZKURT, Auteur ; Gokçe Nur SAY, Auteur ; Berkan SAHIN, Auteur ; Miraç Baris USTA, Auteur ; Merve KALYONCU, Auteur ; Nurullah KOCAK, Auteur ; Osmanli CANSU COBANOGLU, Auteur . - 102050.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 98 (October 2022) . - 102050
Mots-clés : Autism spectrum disorders Retinal nerve fiber layer thickness Optical coherence tomography Index. décimale : PER Périodiques Résumé : Background The study compared retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume of children with autism spectrum disorder (ASD) to those of healthy control group and correlated the RNFL thickness with symptom severity in children with ASD. Method Forty children between the ages of 7 and 12 with normal intelligence levels and who were diagnosed with ASD as per DSM-5 were included in the ASD group. The control group consisted of healthy children, who were matched with subjects in the ASD group in terms of age and gender. The Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS) were used to evaluate the severity of the disease in the cases diagnosed with ASD. The RNFL, macular thickness, and macular volume of all participants were measured optical coherence tomography (OCT). Results The temporal, temporal superior, nasal superior, temporal inferior, and global RNFL thicknesses were significantly lower in the ASD group than in the control group. There was no correlation between the RNFL thickness and ASD symptom severity. The macular thickness and volume were not significantly different between the groups. Conclusion Our data suggest that lower RNFL thickness may relate to atypical brain development in the ASD, and this can be measured in the retina. En ligne : https://doi.org/10.1016/j.rasd.2022.102050 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder / Esen YILDIRIM DEMIRDÖ?EN in Research in Autism Spectrum Disorders, 112 (April 2024)
[article]
Titre : Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Esen YILDIRIM DEMIRDÖ?EN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERI?, Auteur ; Nezahat KURT, Auteur ; Neslihan YÜCE, Auteur Article en page(s) : p.102327 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Hypoxia-inducible factor-1 alpha (HIF-1?) Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1? and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1? and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1? and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1? and apelin serum levels were compared between groups. Additionally, correlations between HIF-1? and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1? and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r = ?0.430, p = 0.018). Serum HIF-1? levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1? and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1?, apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102327[article] Serum hypoxia-inducible factor-1 alpha (HIF-1?) and apelin levels in children and adolescents diagnosed with autism spectrum disorder [Texte imprimé et/ou numérique] / Esen YILDIRIM DEMIRDÖ?EN, Auteur ; Mehmet Akif AKINCI, Auteur ; Abdullah BOZKURT, Auteur ; Özgür ESMERAY, Auteur ; Fatma Betül ÖZGERI?, Auteur ; Nezahat KURT, Auteur ; Neslihan YÜCE, Auteur . - p.102327.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 112 (April 2024) . - p.102327
Mots-clés : Autism spectrum disorder Hypoxia-inducible factor-1 alpha (HIF-1?) Apelin Index. décimale : PER Périodiques Résumé : Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which underlying etiological factors remains unclear. The important environmental factors associated with ASD, include neuroinflammation, hypoxia, and oxidative stress. HIF-1? and apelin are biochemical markers that play important roles in neuroinflammation, hypoxia and oxidative stress. The aim of this study is to determine whether serum HIF-1? and apelin levels differ between children and adolescents with Autism Spectrum Disorder (ASD) and healthy controls. Methods This cross-sectional study included 30 children and adolescents with ASD and 30 healthy controls. HIF-1? and apelin serum levels were measured using commercial enzyme-linked immunosorbent assay kits. Autism symptom severity was evaluated using Childhood Autism Rating Scale (CARS). HIF-1? and apelin serum levels were compared between groups. Additionally, correlations between HIF-1? and apelin serum levels and sociodemographic-clinical variables (age, BMI, CARS total score, ASD severity, psychiatric medication use, psychiatric comorbidity, NLR, SII) were evaluated in the ASD group. Results Serum HIF-1? and apelin levels were statistically significantly higher in the ASD group (p = 0.044, p = 0.041 respectively). Serum apelin levels were negatively correlated with age (r = ?0.430, p = 0.018). Serum HIF-1? levels were positively correlated with NLR (r = 0.627 p < 0.001) and SII (r = 0.609 p < 0.001). There was positive correlation between serum apelin levels and NLR (r = 0.525 p = 0.003) and SII (r = 559 p = 0.002). Conclusion These results suggest that, HIF-1? and apelin may play a potential role in the etiopathogenesis of ASD. Further studies on the subject are needed to reveal the causality between HIF-1?, apelin and ASD. En ligne : https://doi.org/10.1016/j.rasd.2024.102327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523