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Auteur Lawrence SCAHILL |
Documents disponibles écrits par cet auteur (55)
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Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials / Lawrence SCAHILL in Autism, 20-2 (February 2016)
[article]
Titre : Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Denis G SUKHODOLSKY, Auteur ; Emily I. ANDERBERG, Auteur ; Anastasia DIMITROPOULOS, Auteur ; James DZIURA, Auteur ; Michael G. AMAN, Auteur ; James MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Victoria HALLETT, Auteur ; Karol KATZ, Auteur ; Benedetto VITIELLO, Auteur ; Christopher MCDOUGLE, Auteur Article en page(s) : p.145-152 Langues : Anglais (eng) Mots-clés : autism spectrum disorder clinical trials outcome measurement repetitive behavior risperidone Index. décimale : PER Périodiques Résumé : Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4–17?years). At the medication-free baseline, the internal consistency on the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach’s alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74–0.88). There were no differences between active treatment groups. These results indicate that the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test–retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment. En ligne : http://dx.doi.org/10.1177/1362361315574889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278
in Autism > 20-2 (February 2016) . - p.145-152[article] Sensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Denis G SUKHODOLSKY, Auteur ; Emily I. ANDERBERG, Auteur ; Anastasia DIMITROPOULOS, Auteur ; James DZIURA, Auteur ; Michael G. AMAN, Auteur ; James MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Victoria HALLETT, Auteur ; Karol KATZ, Auteur ; Benedetto VITIELLO, Auteur ; Christopher MCDOUGLE, Auteur . - p.145-152.
Langues : Anglais (eng)
in Autism > 20-2 (February 2016) . - p.145-152
Mots-clés : autism spectrum disorder clinical trials outcome measurement repetitive behavior risperidone Index. décimale : PER Périodiques Résumé : Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder to detect change with treatment. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. In Study 2, 49 subjects received risperidone only and 75 subjects received risperidone plus parent training. The combined sample consisted of 187 boys and 38 girls (aged 4–17?years). At the medication-free baseline, the internal consistency on the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder total score was excellent (Cronbach’s alpha = 0.84) and the mean scores were similar across the four groups. Compared to placebo in Study 1, all three active treatment groups showed significant improvement (effect sizes: 0.74–0.88). There were no differences between active treatment groups. These results indicate that the Children’s Yale–Brown Obsessive Compulsive Scale modified for autism spectrum disorder has acceptable test–retest as evidenced by the medium to high correlations in the placebo group and demonstrated sensitivity to change with treatment. En ligne : http://dx.doi.org/10.1177/1362361315574889 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 Social and Emotional Adjustment in Children Affected with Gilles de la Tourette's Syndrome: Associations with ADHD and Family Functioning / Alice S. CARTER in Journal of Child Psychology and Psychiatry, 41-2 (February 2000)
[article]
Titre : Social and Emotional Adjustment in Children Affected with Gilles de la Tourette's Syndrome: Associations with ADHD and Family Functioning Type de document : Texte imprimé et/ou numérique Auteurs : Alice S. CARTER, Auteur ; Deborah O'DONNELL, Auteur ; Robert T. SCHULTZ, Auteur ; Lawrence SCAHILL, Auteur ; James F. LECKMAN, Auteur ; David L. PAULS, Auteur Année de publication : 2000 Article en page(s) : p.215-223 Langues : Anglais (eng) Mots-clés : Tourette syndrome family functioning ADHD social-emotional functioning social behavior Index. décimale : PER Périodiques Résumé : This study examined social-emotional functioning in children with Gilles de la Tourette's syndrome (TS) alone and children with TS and Attention Deficit Hyperactivity Disorder (ADHD). In addition, the contribution of family functioning to social competence was examined. Children with a clinical diagnosis of TS were recruited from the Yale Child Study Center TS specialty clinic. Unaffected control children were recruited through newspaper advertisements and announcements within the university and at area schools. The final sample consisted of 72 children (45 boys and 27 girls) between the ages of 8 and 14. Sixteen children met DMS-III-R criteria for TS, 33 children met criteria for TS and ADHD, and 23 children had no psychiatric diagnoses. Children with TS and ADHD evidenced more externalizing and internalizing behavior problems and poorer social adaptation than children with TS only or unaffected controls. Children with TS only were not significantly different from unaffected controls on most measures of externalizing behaviors and social adaptation but did exhibit more internalizing symptoms. Tic symptom severity was not associated with social, behavioral, or emotional functioning among children with TS, even after stratifying by medication status. However, ADHD diagnosis, obsessional symptom severity, and family functioning were significantly associated with social and emotional adjustment among TS children. Moreover, family functioning was associated with social and emotional adjustment even after controlling for TS and ADHD diagnostic status. These findings demonstrate that much of the social and behavioral dysfunction in children with TS is ADHD-specific and children with TS alone have a very different social-emotional profile than do those with TS plus ADHD. Finally, social-emotional adjustment in children with TS is best understood within the family context. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125
in Journal of Child Psychology and Psychiatry > 41-2 (February 2000) . - p.215-223[article] Social and Emotional Adjustment in Children Affected with Gilles de la Tourette's Syndrome: Associations with ADHD and Family Functioning [Texte imprimé et/ou numérique] / Alice S. CARTER, Auteur ; Deborah O'DONNELL, Auteur ; Robert T. SCHULTZ, Auteur ; Lawrence SCAHILL, Auteur ; James F. LECKMAN, Auteur ; David L. PAULS, Auteur . - 2000 . - p.215-223.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 41-2 (February 2000) . - p.215-223
Mots-clés : Tourette syndrome family functioning ADHD social-emotional functioning social behavior Index. décimale : PER Périodiques Résumé : This study examined social-emotional functioning in children with Gilles de la Tourette's syndrome (TS) alone and children with TS and Attention Deficit Hyperactivity Disorder (ADHD). In addition, the contribution of family functioning to social competence was examined. Children with a clinical diagnosis of TS were recruited from the Yale Child Study Center TS specialty clinic. Unaffected control children were recruited through newspaper advertisements and announcements within the university and at area schools. The final sample consisted of 72 children (45 boys and 27 girls) between the ages of 8 and 14. Sixteen children met DMS-III-R criteria for TS, 33 children met criteria for TS and ADHD, and 23 children had no psychiatric diagnoses. Children with TS and ADHD evidenced more externalizing and internalizing behavior problems and poorer social adaptation than children with TS only or unaffected controls. Children with TS only were not significantly different from unaffected controls on most measures of externalizing behaviors and social adaptation but did exhibit more internalizing symptoms. Tic symptom severity was not associated with social, behavioral, or emotional functioning among children with TS, even after stratifying by medication status. However, ADHD diagnosis, obsessional symptom severity, and family functioning were significantly associated with social and emotional adjustment among TS children. Moreover, family functioning was associated with social and emotional adjustment even after controlling for TS and ADHD diagnostic status. These findings demonstrate that much of the social and behavioral dysfunction in children with TS is ADHD-specific and children with TS alone have a very different social-emotional profile than do those with TS plus ADHD. Finally, social-emotional adjustment in children with TS is best understood within the family context. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 Social Skills Development in Children with Autism Spectrum Disorders: A Review of the Intervention Research / Susan W. WHITE in Journal of Autism and Developmental Disorders, 37-10 (November 2007)
[article]
Titre : Social Skills Development in Children with Autism Spectrum Disorders: A Review of the Intervention Research Type de document : Texte imprimé et/ou numérique Auteurs : Susan W. WHITE, Auteur ; Lawrence SCAHILL, Auteur ; Kathleen KEONIG, Auteur Année de publication : 2007 Article en page(s) : p.1858-1868 Langues : Anglais (eng) Mots-clés : Autism Asperger’s-Disorder Social-skills-training Index. décimale : PER Périodiques Résumé : Social reciprocity deficits are a core feature of the autism spectrum disorders (ASD). This review summarizes the state of research in group-based social skills training programs for school-age children and adolescents with ASD. All published studies of group social skills interventions between 1985 and 2006 were reviewed, as well as dissertations examining group-based social skills intervention programs. To assess the state of the science, a template developed by an NIMH work group was applied to 14 identified studies. Based on this review, the empirical support for this approach is incomplete, but promising intervention strategies were identified. Recommendations for the design of future treatment trials to guide clinical practice are offered.
En ligne : http://dx.doi.org/10.1007/s10803-006-0320-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219
in Journal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1858-1868[article] Social Skills Development in Children with Autism Spectrum Disorders: A Review of the Intervention Research [Texte imprimé et/ou numérique] / Susan W. WHITE, Auteur ; Lawrence SCAHILL, Auteur ; Kathleen KEONIG, Auteur . - 2007 . - p.1858-1868.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 37-10 (November 2007) . - p.1858-1868
Mots-clés : Autism Asperger’s-Disorder Social-skills-training Index. décimale : PER Périodiques Résumé : Social reciprocity deficits are a core feature of the autism spectrum disorders (ASD). This review summarizes the state of research in group-based social skills training programs for school-age children and adolescents with ASD. All published studies of group social skills interventions between 1985 and 2006 were reviewed, as well as dissertations examining group-based social skills intervention programs. To assess the state of the science, a template developed by an NIMH work group was applied to 14 identified studies. Based on this review, the empirical support for this approach is incomplete, but promising intervention strategies were identified. Recommendations for the design of future treatment trials to guide clinical practice are offered.
En ligne : http://dx.doi.org/10.1007/s10803-006-0320-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study / Craig ERICKSON in Journal of Autism and Developmental Disorders, 44-4 (April 2014)
[article]
Titre : STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study Type de document : Texte imprimé et/ou numérique Auteurs : Craig ERICKSON, Auteur ; Jeremy M. VEENSTRA-VANDERWEELE, Auteur ; Raun D. MELMED, Auteur ; James T. MCCRACKEN, Auteur ; Lawrence D. GINSBERG, Auteur ; Linmarie SIKICH, Auteur ; Lawrence SCAHILL, Auteur ; Maryann CHERUBINI, Auteur ; Peter ZAREVICS, Auteur ; Karen WALTON-BOWEN, Auteur ; Randall L. CARPENTER, Auteur ; Mark F. BEAR, Auteur ; Paul P. WANG, Auteur ; Bryan H. KING, Auteur Année de publication : 2014 Article en page(s) : p.958-964 Langues : Anglais (eng) Mots-clés : STX209 Arbaclofen Gamma-aminobutyric acid (GABA) Autism spectrum disorder Clinical trial Index. décimale : PER Périodiques Résumé : STX209 (arbaclofen), a selective GABA-B agonist, is hypothesized to modulate the balance of excitatory to inhibitory neurotransmission, and has shown preliminary evidence of benefit in fragile X syndrome. We evaluated its safety, tolerability, and efficacy in non-syndromic autism spectrum disorders, in an 8-week open-label trial enrolling 32 children and adolescents with either Autistic Disorder or Pervasive Developmental Disorder—Not Otherwise Specified, and a score ?17 on the Aberrant Behavior Checklist (ABC)—Irritability subscale. STX209 was generally well-tolerated. The most common adverse events were agitation and irritability, which typically resolved without dose changes, and were often felt to represent spontaneous variation in underlying symptoms. Improvements were observed on several outcome measures in this exploratory trial, including the ABC-Irritability (the primary endpoint) and the Lethargy/Social Withdrawal subscales, the Social Responsiveness Scale, the CY-BOCS-PDD, and clinical global impression scales. Placebo-controlled study of STX209 is warranted. En ligne : http://dx.doi.org/10.1007/s10803-013-1963-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.958-964[article] STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study [Texte imprimé et/ou numérique] / Craig ERICKSON, Auteur ; Jeremy M. VEENSTRA-VANDERWEELE, Auteur ; Raun D. MELMED, Auteur ; James T. MCCRACKEN, Auteur ; Lawrence D. GINSBERG, Auteur ; Linmarie SIKICH, Auteur ; Lawrence SCAHILL, Auteur ; Maryann CHERUBINI, Auteur ; Peter ZAREVICS, Auteur ; Karen WALTON-BOWEN, Auteur ; Randall L. CARPENTER, Auteur ; Mark F. BEAR, Auteur ; Paul P. WANG, Auteur ; Bryan H. KING, Auteur . - 2014 . - p.958-964.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.958-964
Mots-clés : STX209 Arbaclofen Gamma-aminobutyric acid (GABA) Autism spectrum disorder Clinical trial Index. décimale : PER Périodiques Résumé : STX209 (arbaclofen), a selective GABA-B agonist, is hypothesized to modulate the balance of excitatory to inhibitory neurotransmission, and has shown preliminary evidence of benefit in fragile X syndrome. We evaluated its safety, tolerability, and efficacy in non-syndromic autism spectrum disorders, in an 8-week open-label trial enrolling 32 children and adolescents with either Autistic Disorder or Pervasive Developmental Disorder—Not Otherwise Specified, and a score ?17 on the Aberrant Behavior Checklist (ABC)—Irritability subscale. STX209 was generally well-tolerated. The most common adverse events were agitation and irritability, which typically resolved without dose changes, and were often felt to represent spontaneous variation in underlying symptoms. Improvements were observed on several outcome measures in this exploratory trial, including the ABC-Irritability (the primary endpoint) and the Lethargy/Social Withdrawal subscales, the Social Responsiveness Scale, the CY-BOCS-PDD, and clinical global impression scales. Placebo-controlled study of STX209 is warranted. En ligne : http://dx.doi.org/10.1007/s10803-013-1963-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 Teaching Parents Behavioral Strategies for Autism Spectrum Disorder (ASD): Effects on Stress, Strain, and Competence / S. IADAROLA in Journal of Autism and Developmental Disorders, 48-4 (April 2018)
[article]
Titre : Teaching Parents Behavioral Strategies for Autism Spectrum Disorder (ASD): Effects on Stress, Strain, and Competence Type de document : Texte imprimé et/ou numérique Auteurs : S. IADAROLA, Auteur ; L. LEVATO, Auteur ; B. HARRISON, Auteur ; T. SMITH, Auteur ; L. LECAVALIER, Auteur ; C. JOHNSON, Auteur ; N. SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.1031-1040 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Parent training Parental competence Parental stress Index. décimale : PER Périodiques Résumé : We report on parent outcomes from a randomized clinical trial of parent training (PT) versus psychoeducation (PEP) in 180 children with autism spectrum disorder (ASD) and disruptive behavior. We compare the impact of PT and PEP on parent outcomes: Parenting Stress Index (PSI), Parent Sense of Competence (PSOC), and Caregiver Strain Questionnaire (CGSQ). Mixed-effects linear models evaluated differences at weeks 12 and 24, controlling for baseline scores. Parents in PT reported greater improvement than PEP on the PSOC (ES = 0.34), CGSQ (ES = 0.50), and difficult child subdomain of the PSI (ES = 0.44). This is the largest trial assessing PT in ASD on parent outcomes. PT reduces disruptive behavior in children, and improves parental competence while reducing parental stress and parental strain. En ligne : http://dx.doi.org/10.1007/s10803-017-3339-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1031-1040[article] Teaching Parents Behavioral Strategies for Autism Spectrum Disorder (ASD): Effects on Stress, Strain, and Competence [Texte imprimé et/ou numérique] / S. IADAROLA, Auteur ; L. LEVATO, Auteur ; B. HARRISON, Auteur ; T. SMITH, Auteur ; L. LECAVALIER, Auteur ; C. JOHNSON, Auteur ; N. SWIEZY, Auteur ; Karen E. BEARSS, Auteur ; Lawrence SCAHILL, Auteur . - p.1031-1040.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1031-1040
Mots-clés : Autism spectrum disorder Parent training Parental competence Parental stress Index. décimale : PER Périodiques Résumé : We report on parent outcomes from a randomized clinical trial of parent training (PT) versus psychoeducation (PEP) in 180 children with autism spectrum disorder (ASD) and disruptive behavior. We compare the impact of PT and PEP on parent outcomes: Parenting Stress Index (PSI), Parent Sense of Competence (PSOC), and Caregiver Strain Questionnaire (CGSQ). Mixed-effects linear models evaluated differences at weeks 12 and 24, controlling for baseline scores. Parents in PT reported greater improvement than PEP on the PSOC (ES = 0.34), CGSQ (ES = 0.50), and difficult child subdomain of the PSI (ES = 0.44). This is the largest trial assessing PT in ASD on parent outcomes. PT reduces disruptive behavior in children, and improves parental competence while reducing parental stress and parental strain. En ligne : http://dx.doi.org/10.1007/s10803-017-3339-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=351 PermalinkThe role of emotion regulation and core autism symptoms in the experience of anxiety in autism / Caitlin M. CONNER in Autism, 24-4 (May 2020)
PermalinkTrial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 39-5 (May 2009)
PermalinkUsing qualitative methods to guide scale development for anxiety in youth with autism spectrum disorder / Karen E. BEARSS in Autism, 20-6 (August 2016)
PermalinkUsing the big data approach to clarify the structure of restricted and repetitive behaviors across the most commonly used autism spectrum disorder measures / M. ULJAREVIC in Molecular Autism, 12 (2021)
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