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Autism Research . 9-4Paru le : 01/04/2016 |
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9-4 - April 2016 [Texte imprimé et/ou numérique] . - 2016. Langues : Anglais (eng)
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[article]
Titre : Issue Information Type de document : Texte imprimé et/ou numérique Article en page(s) : p.419-422 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.419-422[article] Issue Information [Texte imprimé et/ou numérique] . - p.419-422.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.419-422
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1549 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 CSF N-glycan profile reveals sialylation deficiency in a patient with GM2 gangliosidosis presenting as childhood disintegrative disorder / Rita BARONE in Autism Research, 9-4 (April 2016)
[article]
Titre : CSF N-glycan profile reveals sialylation deficiency in a patient with GM2 gangliosidosis presenting as childhood disintegrative disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rita BARONE, Auteur ; Luisella STURIALE, Auteur ; Agata FIUMARA, Auteur ; Angelo PALMIGIANO, Auteur ; Rosaria O. BUA, Auteur ; Renata RIZZO, Auteur ; Mario ZAPPIA, Auteur ; Domenico GAROZZO, Auteur Article en page(s) : p.423-428 Langues : Anglais (eng) Mots-clés : autism spectrum disorders CSF N-glycome Tay Sachs Disease GM2 gangliosidosis MALDI-TOF MS Index. décimale : PER Périodiques Résumé : Protein N-glycosylation consists in the synthesis and processing of the oligosaccharide moiety (N-glycan) linked to a protein and it serves several functions for the proper central nervous system (CNS) development and function. Previous experimental and clinical studies have shown the importance of proper glycoprotein sialylation for the synaptic function and the occurrence of autism spectrum disorders (ASD) in the presence of sialylation deficiency in the CNS. Late-onset Tay Sachs disease (LOTSD) is a lysosomal disorder caused by mutations in the HEXA gene resulting in GM2-ganglioside storage in the CNS. It is characterized by progressive neurological impairment and high co-occurrence of psychiatric disturbances. We studied the N-glycome profile of the cerebrospinal fluid (CSF) in a 14 year-old patient with GM2-gangliosidosis (LOTSD). At the age of 4, the patient presented regressive autism fulfilling criteria for childhood disintegrative disorder (CDD). A CSF sample was obtained in the course of diagnostic work-up for the suspicion of an underlying neurodegenerative disorder. We found definite changes of CSF N-glycans due to a dramatic decrease of sialylated biantennary and triantennary structures and an increase of asialo-core fucosylated bisected N-glycans. No changes of total plasma N-glycans were found. Herein findings highlight possible relationships between the early onset psychiatric disturbance featuring CDD in the patient and defective protein sialylation in the CNS. In conclusion, the study first shows aberrant N-glycan structures of CSF proteins in LOTSD; unveils possible pathomechanisms of GM2-gangliosidosis; supports existing relationships between neuropsychiatric disorders and unproper protein glycosylation in the CNS. Autism Res 2016, 9: 423–428. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.423-428[article] CSF N-glycan profile reveals sialylation deficiency in a patient with GM2 gangliosidosis presenting as childhood disintegrative disorder [Texte imprimé et/ou numérique] / Rita BARONE, Auteur ; Luisella STURIALE, Auteur ; Agata FIUMARA, Auteur ; Angelo PALMIGIANO, Auteur ; Rosaria O. BUA, Auteur ; Renata RIZZO, Auteur ; Mario ZAPPIA, Auteur ; Domenico GAROZZO, Auteur . - p.423-428.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.423-428
Mots-clés : autism spectrum disorders CSF N-glycome Tay Sachs Disease GM2 gangliosidosis MALDI-TOF MS Index. décimale : PER Périodiques Résumé : Protein N-glycosylation consists in the synthesis and processing of the oligosaccharide moiety (N-glycan) linked to a protein and it serves several functions for the proper central nervous system (CNS) development and function. Previous experimental and clinical studies have shown the importance of proper glycoprotein sialylation for the synaptic function and the occurrence of autism spectrum disorders (ASD) in the presence of sialylation deficiency in the CNS. Late-onset Tay Sachs disease (LOTSD) is a lysosomal disorder caused by mutations in the HEXA gene resulting in GM2-ganglioside storage in the CNS. It is characterized by progressive neurological impairment and high co-occurrence of psychiatric disturbances. We studied the N-glycome profile of the cerebrospinal fluid (CSF) in a 14 year-old patient with GM2-gangliosidosis (LOTSD). At the age of 4, the patient presented regressive autism fulfilling criteria for childhood disintegrative disorder (CDD). A CSF sample was obtained in the course of diagnostic work-up for the suspicion of an underlying neurodegenerative disorder. We found definite changes of CSF N-glycans due to a dramatic decrease of sialylated biantennary and triantennary structures and an increase of asialo-core fucosylated bisected N-glycans. No changes of total plasma N-glycans were found. Herein findings highlight possible relationships between the early onset psychiatric disturbance featuring CDD in the patient and defective protein sialylation in the CNS. In conclusion, the study first shows aberrant N-glycan structures of CSF proteins in LOTSD; unveils possible pathomechanisms of GM2-gangliosidosis; supports existing relationships between neuropsychiatric disorders and unproper protein glycosylation in the CNS. Autism Res 2016, 9: 423–428. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1541 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Cortical and subcortical glutathione levels in adults with autism spectrum disorder / Alice M. S. DURIEUX in Autism Research, 9-4 (April 2016)
[article]
Titre : Cortical and subcortical glutathione levels in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur Article en page(s) : p.429-435 Langues : Anglais (eng) Mots-clés : autism magnetic resonance spectroscopy glutathione oxidative stress redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.429-435[article] Cortical and subcortical glutathione levels in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur . - p.429-435.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.429-435
Mots-clés : autism magnetic resonance spectroscopy glutathione oxidative stress redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Association and gene–gene interactions study of reelin signaling pathway related genes with autism in the Han Chinese population / Yidong SHEN in Autism Research, 9-4 (April 2016)
[article]
Titre : Association and gene–gene interactions study of reelin signaling pathway related genes with autism in the Han Chinese population Type de document : Texte imprimé et/ou numérique Auteurs : Yidong SHEN, Auteur ; Guanglei XUN, Auteur ; Hui GUO, Auteur ; Yiqun HE, Auteur ; Jianjun OU, Auteur ; Huixi DONG, Auteur ; Kun XIA, Auteur ; Jingping ZHAO, Auteur Article en page(s) : p.436-442 Langues : Anglais (eng) Mots-clés : autism reelin signaling pathway interaction polymorphism Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder with unclear etiology. Reelin had been proposed to participate in the etiology of autism due to its important role in brain development. The goal of this study was to explore the association and gene–gene interactions of reelin signaling pathway related genes (RELN, VLDLR, LRP8, DAB1, FYN, and CDK5) with autism in Han Chinese population. Genotyping data of the six genes were obtained from a recent genome-wide association study performed in 430 autistic children who fulfilled the DSM-IV-TR criteria for autistic disorder, and 1,074 healthy controls. Single marker case-control association analysis and haplotype case-control association analysis were conducted after the data was screened. Multifactor dimensionality reduction (MDR) was applied to further test gene–gene interactions. Neither the single marker nor the haplotype association tests found any significant difference between the autistic group and the control group after permutation test of 1,000 rounds. The 4-locus MDR model (comprising rs6143734, rs1858782, rs634500, and rs1924267 which belong to RELN and DAB1) was determined to be the model with the highest cross-validation consistency (CVC) and testing balanced accuracy. The results indicate that an interaction between RELN and DAB1 may increase the risk of autism in the Han Chinese population. Furthermore, it can also be inferred that the involvement of RELN in the etiology of autism would occur through interaction with DAB1. Autism Res 2016, 9: 436–442. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.436-442[article] Association and gene–gene interactions study of reelin signaling pathway related genes with autism in the Han Chinese population [Texte imprimé et/ou numérique] / Yidong SHEN, Auteur ; Guanglei XUN, Auteur ; Hui GUO, Auteur ; Yiqun HE, Auteur ; Jianjun OU, Auteur ; Huixi DONG, Auteur ; Kun XIA, Auteur ; Jingping ZHAO, Auteur . - p.436-442.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.436-442
Mots-clés : autism reelin signaling pathway interaction polymorphism Index. décimale : PER Périodiques Résumé : Autism is a neurodevelopmental disorder with unclear etiology. Reelin had been proposed to participate in the etiology of autism due to its important role in brain development. The goal of this study was to explore the association and gene–gene interactions of reelin signaling pathway related genes (RELN, VLDLR, LRP8, DAB1, FYN, and CDK5) with autism in Han Chinese population. Genotyping data of the six genes were obtained from a recent genome-wide association study performed in 430 autistic children who fulfilled the DSM-IV-TR criteria for autistic disorder, and 1,074 healthy controls. Single marker case-control association analysis and haplotype case-control association analysis were conducted after the data was screened. Multifactor dimensionality reduction (MDR) was applied to further test gene–gene interactions. Neither the single marker nor the haplotype association tests found any significant difference between the autistic group and the control group after permutation test of 1,000 rounds. The 4-locus MDR model (comprising rs6143734, rs1858782, rs634500, and rs1924267 which belong to RELN and DAB1) was determined to be the model with the highest cross-validation consistency (CVC) and testing balanced accuracy. The results indicate that an interaction between RELN and DAB1 may increase the risk of autism in the Han Chinese population. Furthermore, it can also be inferred that the involvement of RELN in the etiology of autism would occur through interaction with DAB1. Autism Res 2016, 9: 436–442. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1540 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 A Simplified Diagnostic Observational Assessment of Autism Spectrum Disorder in Early Childhood / David GRODBERG in Autism Research, 9-4 (April 2016)
[article]
Titre : A Simplified Diagnostic Observational Assessment of Autism Spectrum Disorder in Early Childhood Type de document : Texte imprimé et/ou numérique Auteurs : David GRODBERG, Auteur ; Paige SIPER, Auteur ; Jesslyn JAMISON, Auteur ; Joseph D. BUXBAUM, Auteur ; Alexander KOLEVZON, Auteur Article en page(s) : p.443-449 Langues : Anglais (eng) Mots-clés : Autism diagnosis Autism mental status exam Observational assessment Index. décimale : PER Périodiques Résumé : Subspecialty physicians who have expertise in the diagnosis of autism spectrum disorder typically do not have the resources to administer comprehensive diagnostic observational assessments for patients suspected of ASD. The autism mental status exam (AMSE) is a free and brief eight-item observation tool that addresses this practice gap. The AMSE, designed by Child and Adolescent Psychiatrists, Developmental Behavioral Pediatricians and Pediatric Neurologists structures the observation and documentation of signs and symptoms of ASD and yields a score. Excellent sensitivity and specificity was demonstrated in a population of high-risk adults. This protocol now investigates the AMSE's test performance in a population of 45 young children age 18 months to 5 years with suspected ASD or social and communication concerns who are evaluated at an autism research center. Each subject received a developmental evaluation, including the AMSE, performed by a Child and Adolescent Psychiatrist, that was followed by independent standardized assessment using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised. A Best Estimate Diagnosis protocol used DSM-5 criteria to ascertain a diagnosis of ASD or non-ASD. Receiver operating characteristic curve analysis was used to determine the AMSE cut point with the highest sensitivity and specificity. Findings indicate an optimized sensitivity of 94% and a specificity of 100% for this high prevalence group. Because of its high classification accuracy in this sample of children the AMSE holds promise as a tool that can support both diagnostic decision making and standardize point of care observational assessment of ASD in high risk children. Autism Res 2016, 9: 443–449. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1539 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.443-449[article] A Simplified Diagnostic Observational Assessment of Autism Spectrum Disorder in Early Childhood [Texte imprimé et/ou numérique] / David GRODBERG, Auteur ; Paige SIPER, Auteur ; Jesslyn JAMISON, Auteur ; Joseph D. BUXBAUM, Auteur ; Alexander KOLEVZON, Auteur . - p.443-449.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.443-449
Mots-clés : Autism diagnosis Autism mental status exam Observational assessment Index. décimale : PER Périodiques Résumé : Subspecialty physicians who have expertise in the diagnosis of autism spectrum disorder typically do not have the resources to administer comprehensive diagnostic observational assessments for patients suspected of ASD. The autism mental status exam (AMSE) is a free and brief eight-item observation tool that addresses this practice gap. The AMSE, designed by Child and Adolescent Psychiatrists, Developmental Behavioral Pediatricians and Pediatric Neurologists structures the observation and documentation of signs and symptoms of ASD and yields a score. Excellent sensitivity and specificity was demonstrated in a population of high-risk adults. This protocol now investigates the AMSE's test performance in a population of 45 young children age 18 months to 5 years with suspected ASD or social and communication concerns who are evaluated at an autism research center. Each subject received a developmental evaluation, including the AMSE, performed by a Child and Adolescent Psychiatrist, that was followed by independent standardized assessment using the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised. A Best Estimate Diagnosis protocol used DSM-5 criteria to ascertain a diagnosis of ASD or non-ASD. Receiver operating characteristic curve analysis was used to determine the AMSE cut point with the highest sensitivity and specificity. Findings indicate an optimized sensitivity of 94% and a specificity of 100% for this high prevalence group. Because of its high classification accuracy in this sample of children the AMSE holds promise as a tool that can support both diagnostic decision making and standardize point of care observational assessment of ASD in high risk children. Autism Res 2016, 9: 443–449. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1539 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Judging the Intensity of Emotional Expression in Faces: the Effects of Colored Tints on Individuals With Autism Spectrum Disorder / Lydia WHITAKER in Autism Research, 9-4 (April 2016)
[article]
Titre : Judging the Intensity of Emotional Expression in Faces: the Effects of Colored Tints on Individuals With Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lydia WHITAKER, Auteur ; Catherine R. G. JONES, Auteur ; Arnold J. WILKINS, Auteur ; Debi ROBERSON, Auteur Article en page(s) : p.450-459 Langues : Anglais (eng) Mots-clés : facial expressions sensory autism spectrum disorder tints overlays visual stress Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often show atypical processing of facial expressions, which may result from visual stress. In the current study, children with ASD and matched controls judged which member of a pair of faces displayed the more intense emotion. Both faces showed anger, disgust, fear, happiness, sadness or surprise but to different degrees. Faces were presented on a monitor that was tinted either gray or with a color previously selected by the participant individually as improving the clarity of text. Judgments of emotional intensity improved significantly with the addition of the preferred colored tint in the ASD group but not in controls, a result consistent with a link between visual stress and impairments in processing facial expressions in individuals with ASD. Autism Res 2016, 9: 450–459. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.450-459[article] Judging the Intensity of Emotional Expression in Faces: the Effects of Colored Tints on Individuals With Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Lydia WHITAKER, Auteur ; Catherine R. G. JONES, Auteur ; Arnold J. WILKINS, Auteur ; Debi ROBERSON, Auteur . - p.450-459.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.450-459
Mots-clés : facial expressions sensory autism spectrum disorder tints overlays visual stress Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) often show atypical processing of facial expressions, which may result from visual stress. In the current study, children with ASD and matched controls judged which member of a pair of faces displayed the more intense emotion. Both faces showed anger, disgust, fear, happiness, sadness or surprise but to different degrees. Faces were presented on a monitor that was tinted either gray or with a color previously selected by the participant individually as improving the clarity of text. Judgments of emotional intensity improved significantly with the addition of the preferred colored tint in the ASD group but not in controls, a result consistent with a link between visual stress and impairments in processing facial expressions in individuals with ASD. Autism Res 2016, 9: 450–459. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Maternal Vocal Feedback to 9-Month-Old Infant Siblings of Children with ASD / Meagan R. TALBOTT in Autism Research, 9-4 (April 2016)
[article]
Titre : Maternal Vocal Feedback to 9-Month-Old Infant Siblings of Children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : Meagan R. TALBOTT, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur Article en page(s) : p.460-470 Langues : Anglais (eng) Mots-clés : autism infant siblings language development maternal responses feedback loop Index. décimale : PER Périodiques Résumé : Infant siblings of children with autism spectrum disorder display differences in early language and social communication skills beginning as early as the first year of life. While environmental influences on early language development are well documented in other infant populations, they have received relatively little attention inside of the infant sibling context. In this study, we analyzed home video diaries collected prospectively as part of a longitudinal study of infant siblings. Infant vowel and consonant-vowel vocalizations and maternal language-promoting and non-promoting verbal responses were scored for 30 infant siblings and 30 low risk control infants at 9 months of age. Analyses evaluated whether infant siblings or their mothers exhibited differences from low risk dyads in vocalization frequency or distribution, and whether mothers' responses were associated with other features of the high risk context. Analyses were conducted with respect to both initial risk group and preliminary outcome classification. Overall, we found no differences in infants' consonant-vowel vocalizations, the frequency of overall maternal utterances, or the distribution of mothers' response types. Both groups of infants produced more vowel than consonant-vowel vocalizations, and both groups of mothers responded to consonant-vowel vocalizations with more language-promoting than non-promoting responses. These results indicate that as a group, mothers of high risk infants provide equally high quality linguistic input to their infants in the first year of life and suggest that impoverished maternal linguistic input does not contribute to high risk infants' initial language difficulties. Implications for intervention strategies are also discussed. Autism Res 2016, 9: 460–470. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.460-470[article] Maternal Vocal Feedback to 9-Month-Old Infant Siblings of Children with ASD [Texte imprimé et/ou numérique] / Meagan R. TALBOTT, Auteur ; Charles A. NELSON, Auteur ; Helen TAGER-FLUSBERG, Auteur . - p.460-470.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.460-470
Mots-clés : autism infant siblings language development maternal responses feedback loop Index. décimale : PER Périodiques Résumé : Infant siblings of children with autism spectrum disorder display differences in early language and social communication skills beginning as early as the first year of life. While environmental influences on early language development are well documented in other infant populations, they have received relatively little attention inside of the infant sibling context. In this study, we analyzed home video diaries collected prospectively as part of a longitudinal study of infant siblings. Infant vowel and consonant-vowel vocalizations and maternal language-promoting and non-promoting verbal responses were scored for 30 infant siblings and 30 low risk control infants at 9 months of age. Analyses evaluated whether infant siblings or their mothers exhibited differences from low risk dyads in vocalization frequency or distribution, and whether mothers' responses were associated with other features of the high risk context. Analyses were conducted with respect to both initial risk group and preliminary outcome classification. Overall, we found no differences in infants' consonant-vowel vocalizations, the frequency of overall maternal utterances, or the distribution of mothers' response types. Both groups of infants produced more vowel than consonant-vowel vocalizations, and both groups of mothers responded to consonant-vowel vocalizations with more language-promoting than non-promoting responses. These results indicate that as a group, mothers of high risk infants provide equally high quality linguistic input to their infants in the first year of life and suggest that impoverished maternal linguistic input does not contribute to high risk infants' initial language difficulties. Implications for intervention strategies are also discussed. Autism Res 2016, 9: 460–470. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1521 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Autistic Traits Moderate the Impact of Reward Learning on Social Behaviour / Maria Serena PANASITI in Autism Research, 9-4 (April 2016)
[article]
Titre : Autistic Traits Moderate the Impact of Reward Learning on Social Behaviour Type de document : Texte imprimé et/ou numérique Auteurs : Maria Serena PANASITI, Auteur ; Ignazio PUZZO, Auteur ; Bhismadev CHAKRABARTI, Auteur Article en page(s) : p.471-479 Langues : Anglais (eng) Mots-clés : reward autism prosocial behaviour empathy Index. décimale : PER Périodiques Résumé : A deficit in empathy has been suggested to underlie social behavioural atypicalities in autism. A parallel theoretical account proposes that reduced social motivation (i.e., low responsivity to social rewards) can account for the said atypicalities. Recent evidence suggests that autistic traits modulate the link between reward and proxy metrics related to empathy. Using an evaluative conditioning paradigm to associate high and low rewards with faces, a previous study has shown that individuals high in autistic traits show reduced spontaneous facial mimicry of faces associated with high vs. low reward. This observation raises the possibility that autistic traits modulate the magnitude of evaluative conditioning. To test this, we investigated (a) if autistic traits could modulate the ability to implicitly associate a reward value to a social stimulus (reward learning/conditioning, using the Implicit Association Task, IAT); (b) if the learned association could modulate participants’ prosocial behaviour (i.e., social reciprocity, measured using the cyberball task); (c) if the strength of this modulation was influenced by autistic traits. In 43 neurotypical participants, we found that autistic traits moderated the relationship of social reward learning on prosocial behaviour but not reward learning itself. This evidence suggests that while autistic traits do not directly influence social reward learning, they modulate the relationship of social rewards with prosocial behaviour. Autism Res 2016, 9: 471–479. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research En ligne : http://dx.doi.org/10.1002/aur.1523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.471-479[article] Autistic Traits Moderate the Impact of Reward Learning on Social Behaviour [Texte imprimé et/ou numérique] / Maria Serena PANASITI, Auteur ; Ignazio PUZZO, Auteur ; Bhismadev CHAKRABARTI, Auteur . - p.471-479.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.471-479
Mots-clés : reward autism prosocial behaviour empathy Index. décimale : PER Périodiques Résumé : A deficit in empathy has been suggested to underlie social behavioural atypicalities in autism. A parallel theoretical account proposes that reduced social motivation (i.e., low responsivity to social rewards) can account for the said atypicalities. Recent evidence suggests that autistic traits modulate the link between reward and proxy metrics related to empathy. Using an evaluative conditioning paradigm to associate high and low rewards with faces, a previous study has shown that individuals high in autistic traits show reduced spontaneous facial mimicry of faces associated with high vs. low reward. This observation raises the possibility that autistic traits modulate the magnitude of evaluative conditioning. To test this, we investigated (a) if autistic traits could modulate the ability to implicitly associate a reward value to a social stimulus (reward learning/conditioning, using the Implicit Association Task, IAT); (b) if the learned association could modulate participants’ prosocial behaviour (i.e., social reciprocity, measured using the cyberball task); (c) if the strength of this modulation was influenced by autistic traits. In 43 neurotypical participants, we found that autistic traits moderated the relationship of social reward learning on prosocial behaviour but not reward learning itself. This evidence suggests that while autistic traits do not directly influence social reward learning, they modulate the relationship of social rewards with prosocial behaviour. Autism Res 2016, 9: 471–479. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research En ligne : http://dx.doi.org/10.1002/aur.1523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Clinical and Cognitive Characteristics Associated with Mathematics Problem Solving in Adolescents with Autism Spectrum Disorder / Tasha M. OSWALD in Autism Research, 9-4 (April 2016)
[article]
Titre : Clinical and Cognitive Characteristics Associated with Mathematics Problem Solving in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tasha M. OSWALD, Auteur ; Jonathan S. BECK, Auteur ; Ana-Maria IOSIF, Auteur ; James B. MCCAULEY, Auteur ; Leslie J. GILHOOLY, Auteur ; John C. MATTER, Auteur ; Marjorie SOLOMON, Auteur Article en page(s) : p.480-490 Langues : Anglais (eng) Mots-clés : adolescents mathematics problem solving anxiety working memory perceptual reasoning Index. décimale : PER Périodiques Résumé : Mathematics achievement in autism spectrum disorder (ASD) has been understudied. However, the ability to solve applied math problems is associated with academic achievement, everyday problem-solving abilities, and vocational outcomes. The paucity of research on math achievement in ASD may be partly explained by the widely-held belief that most individuals with ASD are mathematically gifted, despite emerging evidence to the contrary. The purpose of the study was twofold: to assess the relative proportions of youth with ASD who demonstrate giftedness versus disability on applied math problems, and to examine which cognitive (i.e., perceptual reasoning, verbal ability, working memory) and clinical (i.e., test anxiety) characteristics best predict achievement on applied math problems in ASD relative to typically developing peers. Twenty-seven high-functioning adolescents with ASD and 27 age- and Full Scale IQ-matched typically developing controls were assessed on standardized measures of math problem solving, perceptual reasoning, verbal ability, and test anxiety. Results indicated that 22% of the ASD sample evidenced a mathematics learning disability, while only 4% exhibited mathematical giftedness. The parsimonious linear regression model revealed that the strongest predictor of math problem solving was perceptual reasoning, followed by verbal ability and test anxiety, then diagnosis of ASD. These results inform our theories of math ability in ASD and highlight possible targets of intervention for students with ASD struggling with mathematics. Autism Res 2016, 9: 480–490. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.480-490[article] Clinical and Cognitive Characteristics Associated with Mathematics Problem Solving in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Tasha M. OSWALD, Auteur ; Jonathan S. BECK, Auteur ; Ana-Maria IOSIF, Auteur ; James B. MCCAULEY, Auteur ; Leslie J. GILHOOLY, Auteur ; John C. MATTER, Auteur ; Marjorie SOLOMON, Auteur . - p.480-490.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.480-490
Mots-clés : adolescents mathematics problem solving anxiety working memory perceptual reasoning Index. décimale : PER Périodiques Résumé : Mathematics achievement in autism spectrum disorder (ASD) has been understudied. However, the ability to solve applied math problems is associated with academic achievement, everyday problem-solving abilities, and vocational outcomes. The paucity of research on math achievement in ASD may be partly explained by the widely-held belief that most individuals with ASD are mathematically gifted, despite emerging evidence to the contrary. The purpose of the study was twofold: to assess the relative proportions of youth with ASD who demonstrate giftedness versus disability on applied math problems, and to examine which cognitive (i.e., perceptual reasoning, verbal ability, working memory) and clinical (i.e., test anxiety) characteristics best predict achievement on applied math problems in ASD relative to typically developing peers. Twenty-seven high-functioning adolescents with ASD and 27 age- and Full Scale IQ-matched typically developing controls were assessed on standardized measures of math problem solving, perceptual reasoning, verbal ability, and test anxiety. Results indicated that 22% of the ASD sample evidenced a mathematics learning disability, while only 4% exhibited mathematical giftedness. The parsimonious linear regression model revealed that the strongest predictor of math problem solving was perceptual reasoning, followed by verbal ability and test anxiety, then diagnosis of ASD. These results inform our theories of math ability in ASD and highlight possible targets of intervention for students with ASD struggling with mathematics. Autism Res 2016, 9: 480–490. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Specificity of autonomic arousal to anxiety in children with autism spectrum disorder / Tabitha A. CHIU in Autism Research, 9-4 (April 2016)
[article]
Titre : Specificity of autonomic arousal to anxiety in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Tabitha A. CHIU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jessica BRIAN, Auteur ; Tom CHAU, Auteur ; Azadeh KUSHKI, Auteur Article en page(s) : p.491-501 Langues : Anglais (eng) Mots-clés : physiology psychophysiology autism spectrum disorders autonomic nervous system arousal anxiety cardiac activity Index. décimale : PER Périodiques Résumé : Anxiety is one of the most concerning comorbidities in autism spectrum disorder (ASD) due to its high prevalence, negative impact on physical and psychological well-being, and interaction with core deficits of ASD. Current assessment and treatment of anxiety, which rely on the observation of behavior and self-reports, are often ineffective as ASD is associated with deficits in communication and diminished introspective ability. In this light, autonomic nervous system (ANS) activity has been suggested as a marker of physiological arousal associated with anxiety. However, physiological arousal measured by ANS indices also occurs with other cognitive and emotional processes, and it is unclear whether anxiety-related arousal can be differentiated from that related to other cognitive processes. To address this gap, we investigated the use of linear and nonlinear classification techniques for differentiating anxiety-related arousal from arousal due to three cognitive processes (attention, inhibitory control, and social cognition) and physical activity based on electrocardiography signal features. Our results indicate that over 80% classification accuracy can be achieved, suggesting that ANS response can be used as a specific marker of anxiety-related arousal in a subgroup of children with ASD who demonstrate an increase in heart rate in response to anxiogenic stimuli. Autism Res 2016, 9: 491–501. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.491-501[article] Specificity of autonomic arousal to anxiety in children with autism spectrum disorder [Texte imprimé et/ou numérique] / Tabitha A. CHIU, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jessica BRIAN, Auteur ; Tom CHAU, Auteur ; Azadeh KUSHKI, Auteur . - p.491-501.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.491-501
Mots-clés : physiology psychophysiology autism spectrum disorders autonomic nervous system arousal anxiety cardiac activity Index. décimale : PER Périodiques Résumé : Anxiety is one of the most concerning comorbidities in autism spectrum disorder (ASD) due to its high prevalence, negative impact on physical and psychological well-being, and interaction with core deficits of ASD. Current assessment and treatment of anxiety, which rely on the observation of behavior and self-reports, are often ineffective as ASD is associated with deficits in communication and diminished introspective ability. In this light, autonomic nervous system (ANS) activity has been suggested as a marker of physiological arousal associated with anxiety. However, physiological arousal measured by ANS indices also occurs with other cognitive and emotional processes, and it is unclear whether anxiety-related arousal can be differentiated from that related to other cognitive processes. To address this gap, we investigated the use of linear and nonlinear classification techniques for differentiating anxiety-related arousal from arousal due to three cognitive processes (attention, inhibitory control, and social cognition) and physical activity based on electrocardiography signal features. Our results indicate that over 80% classification accuracy can be achieved, suggesting that ANS response can be used as a specific marker of anxiety-related arousal in a subgroup of children with ASD who demonstrate an increase in heart rate in response to anxiogenic stimuli. Autism Res 2016, 9: 491–501. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1528 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
[article]
Titre : Scientific Summaries for Families with ASD Type de document : Texte imprimé et/ou numérique Article en page(s) : p.502-505 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.502-505[article] Scientific Summaries for Families with ASD [Texte imprimé et/ou numérique] . - p.502-505.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.502-505
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1634 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
[article]
Titre : Message from the President Type de document : Texte imprimé et/ou numérique Article en page(s) : p.506-507 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1635 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.506-507[article] Message from the President [Texte imprimé et/ou numérique] . - p.506-507.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.506-507
Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1635 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287