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Cortical and subcortical glutathione levels in adults with autism spectrum disorder / Alice M. S. DURIEUX in Autism Research, 9-4 (April 2016)
[article]
Titre : Cortical and subcortical glutathione levels in adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur Article en page(s) : p.429-435 Langues : Anglais (eng) Mots-clés : autism magnetic resonance spectroscopy glutathione oxidative stress redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287
in Autism Research > 9-4 (April 2016) . - p.429-435[article] Cortical and subcortical glutathione levels in adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Alice M. S. DURIEUX, Auteur ; Jamie HORDER, Auteur ; M. Andreina MENDEZ, Auteur ; Alice EGERTON, Auteur ; Steven C. R. WILLIAMS, Auteur ; C. Ellie WILSON, Auteur ; Debbie SPAIN, Auteur ; Clodagh M. MURPHY, Auteur ; Dene ROBERTSON, Auteur ; Gareth J. BARKER, Auteur ; Declan G. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur . - p.429-435.
Langues : Anglais (eng)
in Autism Research > 9-4 (April 2016) . - p.429-435
Mots-clés : autism magnetic resonance spectroscopy glutathione oxidative stress redox Index. décimale : PER Périodiques Résumé : Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. Autism Res 2016, 9: 429–435. © 2015 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. En ligne : http://dx.doi.org/10.1002/aur.1522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=287 Biochemical Effects of Ribose and NADH Therapy in Children with Autism / Stuart H. FREEDENFELD in Autism Insights, 3 ([01/01/2011])
[article]
Titre : Biochemical Effects of Ribose and NADH Therapy in Children with Autism Type de document : Application, site Internet Auteurs : Stuart H. FREEDENFELD, Auteur ; Kim HAMADA, Auteur ; Tapan AUDHYA, Auteur ; James B. ADAMS, Auteur Année de publication : 2011 Article en page(s) : 11 p. Langues : Anglais (eng) Mots-clés : NADH ribose autism mitochondria glutathione methylation adenosine Index. décimale : PER Périodiques Résumé : Objectives: Several studies have previously indicated that children with autism often have abnormalities in methylation, glutathione redox, and mitochondrial function. A common feature of these abnormalities is that they are affected directly or indirectly by levels of ribose, reduced Nicotinamide Adenine Dinucleotide (NADH), reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH), and Adenosine-5’-triphosphate (ATP). The objective of this study was to investigate the possible biochemical effect of ribose therapy and NADH therapy on children with autism.
Design: In a pilot study, ribose was administered orally to eight children with autism for two weeks, and NADH was administered orally to another group of eight children with autism for two weeks. Children were ages 3–9 years with clinical symptoms of low energy and/or low muscle tone. Eighteen biomarkers related to methylation (including S-adenosylmethionine (SAM)), glutathione (including the reduced form, GSH, and the oxidized form GSSG), adenosine triphosphate (ATP), and folic acid and were measured at the beginning and end of the therapy.
Results: The NADH group had significant improvements in levels of ribose-5-phosphate, GSH, NADH, NADPH, and SAM. The Ribose group had significant improvements in ribose-5-phosphate, NADH, ATP, and folic acid. There was no significant change in GSSG in either group after two weeks.
Conclusions: This small study suggests that both NADH and Ribose therapy results in some improvements in biochemistry, and may be beneficial for treating children with those abnormalities. Larger studies are recommended.En ligne : http://dx.doi.org/10.4137/AUI.S6947 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131
in Autism Insights > 3 [01/01/2011] . - 11 p.[article] Biochemical Effects of Ribose and NADH Therapy in Children with Autism [Application, site Internet] / Stuart H. FREEDENFELD, Auteur ; Kim HAMADA, Auteur ; Tapan AUDHYA, Auteur ; James B. ADAMS, Auteur . - 2011 . - 11 p.
Langues : Anglais (eng)
in Autism Insights > 3 [01/01/2011] . - 11 p.
Mots-clés : NADH ribose autism mitochondria glutathione methylation adenosine Index. décimale : PER Périodiques Résumé : Objectives: Several studies have previously indicated that children with autism often have abnormalities in methylation, glutathione redox, and mitochondrial function. A common feature of these abnormalities is that they are affected directly or indirectly by levels of ribose, reduced Nicotinamide Adenine Dinucleotide (NADH), reduced Nicotinamide Adenine Dinucleotide Phosphate (NADPH), and Adenosine-5’-triphosphate (ATP). The objective of this study was to investigate the possible biochemical effect of ribose therapy and NADH therapy on children with autism.
Design: In a pilot study, ribose was administered orally to eight children with autism for two weeks, and NADH was administered orally to another group of eight children with autism for two weeks. Children were ages 3–9 years with clinical symptoms of low energy and/or low muscle tone. Eighteen biomarkers related to methylation (including S-adenosylmethionine (SAM)), glutathione (including the reduced form, GSH, and the oxidized form GSSG), adenosine triphosphate (ATP), and folic acid and were measured at the beginning and end of the therapy.
Results: The NADH group had significant improvements in levels of ribose-5-phosphate, GSH, NADH, NADPH, and SAM. The Ribose group had significant improvements in ribose-5-phosphate, NADH, ATP, and folic acid. There was no significant change in GSSG in either group after two weeks.
Conclusions: This small study suggests that both NADH and Ribose therapy results in some improvements in biochemistry, and may be beneficial for treating children with those abnormalities. Larger studies are recommended.En ligne : http://dx.doi.org/10.4137/AUI.S6947 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131 Prediction learning in adults with autism and its molecular correlates / L. A. SAPEY-TRIOMPHE in Molecular Autism, 12 (2021)
[article]
Titre : Prediction learning in adults with autism and its molecular correlates Type de document : Texte imprimé et/ou numérique Auteurs : L. A. SAPEY-TRIOMPHE, Auteur ; J. TEMMERMAN, Auteur ; N. A. J. PUTS, Auteur ; J. WAGEMANS, Auteur Article en page(s) : 64 p. Langues : Anglais (eng) Mots-clés : Asd Gaba Glutamate Glutathione Magnetic resonance spectroscopy Prediction Prior Probabilistic learning Uncertainty Volatility Index. décimale : PER Périodiques Résumé : BACKGROUND: According to Bayesian hypotheses, individuals with Autism Spectrum Disorder (ASD) have difficulties making accurate predictions about their environment. In particular, the mechanisms by which they assign precision to predictions or sensory inputs would be suboptimal in ASD. These mechanisms are thought to be mostly mediated by glutamate and GABA. Here, we aimed to shed light on prediction learning in ASD and on its neurobiological correlates. METHODS: Twenty-six neurotypical and 26 autistic adults participated in an associative learning task where they had to learn a probabilistic association between a tone and the rotation direction of two dots, in a volatile context. They also took part in magnetic resonance spectroscopy (MRS) measurements to quantify Glx (glutamate and glutamine), GABA?+?and glutathione in a low-level perceptual region (occipital cortex) and in a higher-level region involved in prediction learning (inferior frontal gyrus). RESULTS: Neurotypical and autistic adults had their percepts biased by their expectations, and this bias was smaller for individuals with a more atypical sensory sensitivity. Both groups were able to learn the association and to update their beliefs after a change in contingency. Interestingly, the percentage of correct predictions was correlated with the Glx/GABA?+?ratio in the occipital cortex (positive correlation) and in the right inferior frontal gyrus (negative correlation). In this region, MRS results also showed an increased concentration of Glx in the ASD group compared to the neurotypical group. LIMITATIONS: We used a quite restrictive approach to select the MR spectra showing a good fit, which led to the exclusion of some MRS datasets and therefore to the reduction of the sample size for certain metabolites/regions. CONCLUSIONS: Autistic adults appeared to have intact abilities to make predictions in this task, in contrast with the Bayesian hypotheses of ASD. Yet, higher ratios of Glx/GABA?+?in a frontal region were associated with decreased predictive abilities, and ASD individuals tended to have more Glx in this region. This neurobiological difference might contribute to suboptimal predictive mechanisms in ASD in certain contexts. En ligne : http://dx.doi.org/10.1186/s13229-021-00470-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 64 p.[article] Prediction learning in adults with autism and its molecular correlates [Texte imprimé et/ou numérique] / L. A. SAPEY-TRIOMPHE, Auteur ; J. TEMMERMAN, Auteur ; N. A. J. PUTS, Auteur ; J. WAGEMANS, Auteur . - 64 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 64 p.
Mots-clés : Asd Gaba Glutamate Glutathione Magnetic resonance spectroscopy Prediction Prior Probabilistic learning Uncertainty Volatility Index. décimale : PER Périodiques Résumé : BACKGROUND: According to Bayesian hypotheses, individuals with Autism Spectrum Disorder (ASD) have difficulties making accurate predictions about their environment. In particular, the mechanisms by which they assign precision to predictions or sensory inputs would be suboptimal in ASD. These mechanisms are thought to be mostly mediated by glutamate and GABA. Here, we aimed to shed light on prediction learning in ASD and on its neurobiological correlates. METHODS: Twenty-six neurotypical and 26 autistic adults participated in an associative learning task where they had to learn a probabilistic association between a tone and the rotation direction of two dots, in a volatile context. They also took part in magnetic resonance spectroscopy (MRS) measurements to quantify Glx (glutamate and glutamine), GABA?+?and glutathione in a low-level perceptual region (occipital cortex) and in a higher-level region involved in prediction learning (inferior frontal gyrus). RESULTS: Neurotypical and autistic adults had their percepts biased by their expectations, and this bias was smaller for individuals with a more atypical sensory sensitivity. Both groups were able to learn the association and to update their beliefs after a change in contingency. Interestingly, the percentage of correct predictions was correlated with the Glx/GABA?+?ratio in the occipital cortex (positive correlation) and in the right inferior frontal gyrus (negative correlation). In this region, MRS results also showed an increased concentration of Glx in the ASD group compared to the neurotypical group. LIMITATIONS: We used a quite restrictive approach to select the MR spectra showing a good fit, which led to the exclusion of some MRS datasets and therefore to the reduction of the sample size for certain metabolites/regions. CONCLUSIONS: Autistic adults appeared to have intact abilities to make predictions in this task, in contrast with the Bayesian hypotheses of ASD. Yet, higher ratios of Glx/GABA?+?in a frontal region were associated with decreased predictive abilities, and ASD individuals tended to have more Glx in this region. This neurobiological difference might contribute to suboptimal predictive mechanisms in ASD in certain contexts. En ligne : http://dx.doi.org/10.1186/s13229-021-00470-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism / Stepan MELNYK in Journal of Autism and Developmental Disorders, 42-3 (March 2012)
[article]
Titre : Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur Année de publication : 2012 Article en page(s) : p.367-377 Langues : Anglais (eng) Mots-clés : Autism Oxidative stress Metabolic Epigenetics Glutathione DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152
in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377[article] Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism [Texte imprimé et/ou numérique] / Stepan MELNYK, Auteur ; George J. FUCHS, Auteur ; Eldon SCHULZ, Auteur ; Maya LOPEZ, Auteur ; Stephen G. KAHLER, Auteur ; Jill J. FUSSELL, Auteur ; Jayne BELLANDO, Auteur ; Oleksandra PAVLIV, Auteur ; Shannon ROSE, Auteur ; Lisa SEIDEL, Auteur ; David W. GAYLOR, Auteur ; S. Jill JAMES, Auteur . - 2012 . - p.367-377.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-3 (March 2012) . - p.367-377
Mots-clés : Autism Oxidative stress Metabolic Epigenetics Glutathione DNA methylation Index. décimale : PER Périodiques Résumé : Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of autism. We investigated the dynamics of an integrated metabolic pathway essential for cellular antioxidant and methylation capacity in 68 children with autism, 54 age-matched control children and 40 unaffected siblings. The metabolic profile of unaffected siblings differed significantly from case siblings but not from controls. Oxidative protein/DNA damage and DNA hypomethylation (epigenetic alteration) were found in autistic children but not paired siblings or controls. These data indicate that the deficit in antioxidant and methylation capacity is specific for autism and may promote cellular damage and altered epigenetic gene expression. Further, these results suggest a plausible mechanism by which pro-oxidant environmental stressors may modulate genetic predisposition to autism. En ligne : http://dx.doi.org/10.1007/s10803-011-1260-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152