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Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study / A. L. HOYLAND in Molecular Autism, 10 (2019)
[article]
Titre : Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study Type de document : Texte imprimé et/ou numérique Auteurs : A. L. HOYLAND, Auteur ; T. NAERLAND, Auteur ; M. ENGSTROM, Auteur ; T. TORSKE, Auteur ; S. LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur Article en page(s) : 10 p. Langues : Anglais (eng) Mots-clés : *asd *erp *n1 *P3a *Passive condition Research Ethics South East (2013/1236/REK South-East). Written informed consent was obtained from participants and/ or parents necessary due to age.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: The core features of autism spectrum disorder (ASD) are easily recognizable in non-structured clinical and real-life situations. The features are often difficult to capture in structured laboratory settings, and the results from tests do not necessarily reflect symptom severity. We investigated neurophysiological processing in the passive parts of a cued Go-NoGo task, using the active parts of the test as a comparator. Methods: Forty-nine adolescents diagnosed with ASD and 49 typically developing (TD) adolescents (age 12-21 years) were included. Daily life executive function was assessed with the Behavior Rating Inventory of Executive Function (BRIEF). We applied a visual cued Go-NoGo task and recorded event-related potentials (ERPs). We investigated occipital N1, a component related to early perception of visual stimuli, and P3a, a fronto-central component related to switching of attention, in the passive and active parts of the test. Results: During the passive parts, the ASD group had statistically significantly longer N1 latency (p < 0.001, Cohens d = 0.75) and enhanced amplitude of P3a (p = 0.002, Cohens d = 0.64) compared to the TD, while no significant differences were observed in the active parts. Both components correlated significantly with the Behavioral Regulation Index of the BRIEF (partial correlation r = 0.35, p = 0.003). Conclusion: Delayed N1 response, indicating altered visual perception, and enhanced P3a response, indicating increased neural activation related to attention allocation, were found during the passive parts of a Go-NoGo task in ASD participants. These abnormal ERP signals in the non-structured settings were associated with everyday executive function, suggesting that neurophysiolocal measures related to atypical control of alertness and "hyper-awareness" underlie daily life dysfunction in ASD. Assessments during passive settings have a potential to reveal core neurobiological substrates of ASD. En ligne : https://dx.doi.org/10.1186/s13229-019-0259-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389
in Molecular Autism > 10 (2019) . - 10 p.[article] Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study [Texte imprimé et/ou numérique] / A. L. HOYLAND, Auteur ; T. NAERLAND, Auteur ; M. ENGSTROM, Auteur ; T. TORSKE, Auteur ; S. LYDERSEN, Auteur ; Ole A. ANDREASSEN, Auteur . - 10 p.
Langues : Anglais (eng)
in Molecular Autism > 10 (2019) . - 10 p.
Mots-clés : *asd *erp *n1 *P3a *Passive condition Research Ethics South East (2013/1236/REK South-East). Written informed consent was obtained from participants and/ or parents necessary due to age.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: The core features of autism spectrum disorder (ASD) are easily recognizable in non-structured clinical and real-life situations. The features are often difficult to capture in structured laboratory settings, and the results from tests do not necessarily reflect symptom severity. We investigated neurophysiological processing in the passive parts of a cued Go-NoGo task, using the active parts of the test as a comparator. Methods: Forty-nine adolescents diagnosed with ASD and 49 typically developing (TD) adolescents (age 12-21 years) were included. Daily life executive function was assessed with the Behavior Rating Inventory of Executive Function (BRIEF). We applied a visual cued Go-NoGo task and recorded event-related potentials (ERPs). We investigated occipital N1, a component related to early perception of visual stimuli, and P3a, a fronto-central component related to switching of attention, in the passive and active parts of the test. Results: During the passive parts, the ASD group had statistically significantly longer N1 latency (p < 0.001, Cohens d = 0.75) and enhanced amplitude of P3a (p = 0.002, Cohens d = 0.64) compared to the TD, while no significant differences were observed in the active parts. Both components correlated significantly with the Behavioral Regulation Index of the BRIEF (partial correlation r = 0.35, p = 0.003). Conclusion: Delayed N1 response, indicating altered visual perception, and enhanced P3a response, indicating increased neural activation related to attention allocation, were found during the passive parts of a Go-NoGo task in ASD participants. These abnormal ERP signals in the non-structured settings were associated with everyday executive function, suggesting that neurophysiolocal measures related to atypical control of alertness and "hyper-awareness" underlie daily life dysfunction in ASD. Assessments during passive settings have a potential to reveal core neurobiological substrates of ASD. En ligne : https://dx.doi.org/10.1186/s13229-019-0259-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 Impact of a digital Modified Checklist for Autism in Toddlers-Revised on likelihood and age of autism diagnosis and referral for developmental evaluation / Samantha MAJOR in Autism, 24-7 (October 2020)
[article]
Titre : Impact of a digital Modified Checklist for Autism in Toddlers-Revised on likelihood and age of autism diagnosis and referral for developmental evaluation Type de document : Texte imprimé et/ou numérique Auteurs : Samantha MAJOR, Auteur ; Kathleen CAMPBELL, Auteur ; Steven ESPINOSA, Auteur ; Jeffrey P. BAKER, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Guillermo SAPIRO, Auteur ; Saritha VERMEER, Auteur ; Geraldine DAWSON, Auteur Article en page(s) : p.1629-1638 Langues : Anglais (eng) Mots-clés : *asd *developmental evaluation *quality improvement *screening Inc, LabCorp, Inc, Roche Pharmaceutical Company, and Tris Pharma, and is a consultant to Apple, Gerson Lehrman Group, Guidepoint, Inc, Axial Ventures, and Teva Pharmaceutical. GD and GS are associated with DASIO, LLC. GD has received book royalties from Guilford Press, Oxford University Press, Springer Nature Press. GD has the following patent applications: 1802952, 1802942, 15141391, and 16493754. SE, KC, GD, and GS have developed technology that has been licensed and they and Duke University have benefited financially. Index. décimale : PER Périodiques Résumé : This was a project in primary care for young children (1-2?years old). We tested a parent questionnaire on a tablet. This tablet questionnaire asked questions to see whether the child may have autism. We compared the paper and pencil version of the questionnaire to the tablet questionnaire. We read the medical charts for the children until they were 4?years old to see whether they ended up having autism. We found that doctors were more likely to recommend an autism evaluation when a parent used the tablet questionnaire. We think that the tablet's automatic scoring feature helped the doctors. We also think that the doctors benefited from the advice the tablet gave them. En ligne : http://dx.doi.org/10.1177/1362361320916656 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431
in Autism > 24-7 (October 2020) . - p.1629-1638[article] Impact of a digital Modified Checklist for Autism in Toddlers-Revised on likelihood and age of autism diagnosis and referral for developmental evaluation [Texte imprimé et/ou numérique] / Samantha MAJOR, Auteur ; Kathleen CAMPBELL, Auteur ; Steven ESPINOSA, Auteur ; Jeffrey P. BAKER, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Guillermo SAPIRO, Auteur ; Saritha VERMEER, Auteur ; Geraldine DAWSON, Auteur . - p.1629-1638.
Langues : Anglais (eng)
in Autism > 24-7 (October 2020) . - p.1629-1638
Mots-clés : *asd *developmental evaluation *quality improvement *screening Inc, LabCorp, Inc, Roche Pharmaceutical Company, and Tris Pharma, and is a consultant to Apple, Gerson Lehrman Group, Guidepoint, Inc, Axial Ventures, and Teva Pharmaceutical. GD and GS are associated with DASIO, LLC. GD has received book royalties from Guilford Press, Oxford University Press, Springer Nature Press. GD has the following patent applications: 1802952, 1802942, 15141391, and 16493754. SE, KC, GD, and GS have developed technology that has been licensed and they and Duke University have benefited financially. Index. décimale : PER Périodiques Résumé : This was a project in primary care for young children (1-2?years old). We tested a parent questionnaire on a tablet. This tablet questionnaire asked questions to see whether the child may have autism. We compared the paper and pencil version of the questionnaire to the tablet questionnaire. We read the medical charts for the children until they were 4?years old to see whether they ended up having autism. We found that doctors were more likely to recommend an autism evaluation when a parent used the tablet questionnaire. We think that the tablet's automatic scoring feature helped the doctors. We also think that the doctors benefited from the advice the tablet gave them. En ligne : http://dx.doi.org/10.1177/1362361320916656 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 The relationship between intolerance of uncertainty and anxiety in autism: A systematic literature review and meta-analysis / Richard JENKINSON in Autism, 24-8 (November 2020)
[article]
Titre : The relationship between intolerance of uncertainty and anxiety in autism: A systematic literature review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Richard JENKINSON, Auteur ; Elizabeth MILNE, Auteur ; Andrew THOMPSON, Auteur Article en page(s) : p.1933-1944 Langues : Anglais (eng) Mots-clés : *asd *anxiety *autism *autism spectrum disorders *intolerance of uncertainty *meta-analysis *systematic review of interest with respect to the research, authorship and/or publication of this article. Index. décimale : PER Périodiques Résumé : People who find it especially hard to cope with the unexpected or unknown are said to have an intolerance of uncertainty. Autistic individuals often report a preference for certainty and experience levels of anxiety that can interfere with their daily life. Understanding more about the link between the intolerance of uncertainty and anxiety in autistic people might lead to better treatments for anxiety being developed. Therefore, this work aimed to review previous research in order to explore this link. Twelve studies were found and their results were compared and contrasted. The autistic people who participated in the studies completed questionnaires that suggested a large number of them experienced very high levels of anxiety and intolerance of uncertainty. Of 10 studies that used relevant statistics, nine found a statistically significant link between anxiety and the intolerance of uncertainty. In general, the strength of the link was about the same as previous research found in people who did not have a diagnosis of autism. This might mean that interventions that aim to help people who are intolerant of uncertainty could be effective for autistic individuals. En ligne : http://dx.doi.org/10.1177/1362361320932437 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431
in Autism > 24-8 (November 2020) . - p.1933-1944[article] The relationship between intolerance of uncertainty and anxiety in autism: A systematic literature review and meta-analysis [Texte imprimé et/ou numérique] / Richard JENKINSON, Auteur ; Elizabeth MILNE, Auteur ; Andrew THOMPSON, Auteur . - p.1933-1944.
Langues : Anglais (eng)
in Autism > 24-8 (November 2020) . - p.1933-1944
Mots-clés : *asd *anxiety *autism *autism spectrum disorders *intolerance of uncertainty *meta-analysis *systematic review of interest with respect to the research, authorship and/or publication of this article. Index. décimale : PER Périodiques Résumé : People who find it especially hard to cope with the unexpected or unknown are said to have an intolerance of uncertainty. Autistic individuals often report a preference for certainty and experience levels of anxiety that can interfere with their daily life. Understanding more about the link between the intolerance of uncertainty and anxiety in autistic people might lead to better treatments for anxiety being developed. Therefore, this work aimed to review previous research in order to explore this link. Twelve studies were found and their results were compared and contrasted. The autistic people who participated in the studies completed questionnaires that suggested a large number of them experienced very high levels of anxiety and intolerance of uncertainty. Of 10 studies that used relevant statistics, nine found a statistically significant link between anxiety and the intolerance of uncertainty. In general, the strength of the link was about the same as previous research found in people who did not have a diagnosis of autism. This might mean that interventions that aim to help people who are intolerant of uncertainty could be effective for autistic individuals. En ligne : http://dx.doi.org/10.1177/1362361320932437 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431