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The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood – a prospective cohort study / Anna-Maija TOLPPANEN in Journal of Child Psychology and Psychiatry, 53-7 (July 2012)
[article]
Titre : The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood – a prospective cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Anna-Maija TOLPPANEN, Auteur ; Adrian SAYERS, Auteur ; William D. FRASER, Auteur ; Glyn LEWIS, Auteur ; Stanley ZAMMIT, Auteur ; Debbie A. LAWLOR, Auteur Année de publication : 2012 Article en page(s) : p.757-766 Langues : Anglais (eng) Mots-clés : 25-Hydroxyvitamin D calcium parathyroid hormone child depression ALSPAC Index. décimale : PER Périodiques Résumé : Background: Depression in adolescence is common and early onset predicts worse outcome in adulthood. Studies in adults have suggested a link between higher total 25-hydroxyvitamin D [25(OH)D] concentrations and lower risk of depression.
Objectives: To investigate (a) the association between serum 25(OH)D2 and 25(OH)D3 concentrations and depressive symptoms in children, and (b) whether the associations of 25(OH)D2 and 25(OH)D3 are different from, and independent of, each other.
Methods: Prospective cohort study with serum 25(OH)D2 and 25(OH)D3 concentrations measured at mean age of 9.8 years and depressive symptoms assessed with the Mood and Feelings Questionnaire by a trained interviewer at the mean ages of 10.6 years (n = 2,759) and 13.8 years (n = 2,752).
Results: Higher concentrations of 25(OH)D3 assessed at mean age 9.8 years were associated with lower levels of depressive symptoms at age 13.8 years [adjusted risk ratio (RR; 95% confidence interval (CI)): 0.90 (0.86–0.95)], but not at age 10.6 years [adjusted RR (95% CI): 0.98 (0.93–1.03)] and with increased odds of decreasing symptoms between age 10.6 and 13.8 years [adjusted RR (95% CI): 1.08 (1.01–1.16)]. Serum 25(OH)D2 concentrations were not associated with depressive symptoms.
Conclusions: This is the first study in children to suggest that the association between 25(OH)D3 concentrations and depression emerges in childhood. The association is independent of a wide range of potential confounding factors, and appears to be stronger with greater time separation between assessment of 25(OH)D3 and assessment of depressive symptoms. Confirmation of our findings in large prospective studies and trials would be valuable.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02518.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166
in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.757-766[article] The association of serum 25-hydroxyvitamin D3 and D2 with depressive symptoms in childhood – a prospective cohort study [Texte imprimé et/ou numérique] / Anna-Maija TOLPPANEN, Auteur ; Adrian SAYERS, Auteur ; William D. FRASER, Auteur ; Glyn LEWIS, Auteur ; Stanley ZAMMIT, Auteur ; Debbie A. LAWLOR, Auteur . - 2012 . - p.757-766.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 53-7 (July 2012) . - p.757-766
Mots-clés : 25-Hydroxyvitamin D calcium parathyroid hormone child depression ALSPAC Index. décimale : PER Périodiques Résumé : Background: Depression in adolescence is common and early onset predicts worse outcome in adulthood. Studies in adults have suggested a link between higher total 25-hydroxyvitamin D [25(OH)D] concentrations and lower risk of depression.
Objectives: To investigate (a) the association between serum 25(OH)D2 and 25(OH)D3 concentrations and depressive symptoms in children, and (b) whether the associations of 25(OH)D2 and 25(OH)D3 are different from, and independent of, each other.
Methods: Prospective cohort study with serum 25(OH)D2 and 25(OH)D3 concentrations measured at mean age of 9.8 years and depressive symptoms assessed with the Mood and Feelings Questionnaire by a trained interviewer at the mean ages of 10.6 years (n = 2,759) and 13.8 years (n = 2,752).
Results: Higher concentrations of 25(OH)D3 assessed at mean age 9.8 years were associated with lower levels of depressive symptoms at age 13.8 years [adjusted risk ratio (RR; 95% confidence interval (CI)): 0.90 (0.86–0.95)], but not at age 10.6 years [adjusted RR (95% CI): 0.98 (0.93–1.03)] and with increased odds of decreasing symptoms between age 10.6 and 13.8 years [adjusted RR (95% CI): 1.08 (1.01–1.16)]. Serum 25(OH)D2 concentrations were not associated with depressive symptoms.
Conclusions: This is the first study in children to suggest that the association between 25(OH)D3 concentrations and depression emerges in childhood. The association is independent of a wide range of potential confounding factors, and appears to be stronger with greater time separation between assessment of 25(OH)D3 and assessment of depressive symptoms. Confirmation of our findings in large prospective studies and trials would be valuable.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02518.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=166 Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood / Yamna ALI in Autism, 23-3 (April 2019)
[article]
Titre : Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood Type de document : Texte imprimé et/ou numérique Auteurs : Yamna ALI, Auteur ; Laura N. ANDERSON, Auteur ; Sharon SMILE, Auteur ; Yang CHEN, Auteur ; Cornelia M. BORKHOFF, Auteur ; Christine KOROSHEGYI, Auteur ; Gerald LEBOVIC, Auteur ; Patricia C. PARKIN, Auteur ; Catherine S. BIRKEN, Auteur ; Peter SZATMARI, Auteur ; Jonathon L. MAGUIRE, Auteur Article en page(s) : p.584-593 Langues : Anglais (eng) Mots-clés : 25-hydroxyvitamin D autism spectrum disorder early childhood vitamin D Index. décimale : PER Périodiques Résumé : Several studies have suggested an association between vitamin D in childhood and autism spectrum disorder. No prospective studies have evaluated whether lower vitamin D levels precede ASD diagnoses – a necessary condition for causality. The objective of this study was to prospectively evaluate whether vitamin D serum levels in early childhood was associated with incident physician diagnosed ASD. A prospective cohort study was conducted using data from preschool-aged children in the TARGet Kids! practice-based research network in Toronto, Canada, from June 2008 to July 2015. 25-hydroxyvitamin D concentration was measured through blood samples and vitamin D supplementation from parent report. Autism spectrum disorder diagnosis was determined from medical records at follow-up visits. Covariates included age, sex, family history of autism spectrum disorder, maternal ethnicity, and neighborhood household income. Unadjusted and adjusted relative risks and 95% confidence intervals were estimated using Poisson regression with a robust error variance. In this study, 3852 children were included. Autism spectrum disorder diagnosis was identified in 41 children (incidence?=?1.1%) over the observation period (average follow-up time?=?2.5?years). An association between 25-hydroxyvitamin D concentration and autism spectrum disorder was not identified in the unadjusted (relative risk?=?1.04, 95% confidence interval: 0.97, 1.11 per 10?nmol/L increase in 25-hydroxyvitamin D concentration) or adjusted models (adjusted relative risk?=?1.06; 95% confidence interval: 0.95, 1.18). An association between vitamin D supplementation in early childhood and autism spectrum disorder was also not identified (adjusted relative risk?=?0.86, 95% confidence interval: 0.46, 1.62). Vitamin D in early childhood may not be associated with incident physician diagnoses of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361318756787 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392
in Autism > 23-3 (April 2019) . - p.584-593[article] Prospective cohort study of vitamin D and autism spectrum disorder diagnoses in early childhood [Texte imprimé et/ou numérique] / Yamna ALI, Auteur ; Laura N. ANDERSON, Auteur ; Sharon SMILE, Auteur ; Yang CHEN, Auteur ; Cornelia M. BORKHOFF, Auteur ; Christine KOROSHEGYI, Auteur ; Gerald LEBOVIC, Auteur ; Patricia C. PARKIN, Auteur ; Catherine S. BIRKEN, Auteur ; Peter SZATMARI, Auteur ; Jonathon L. MAGUIRE, Auteur . - p.584-593.
Langues : Anglais (eng)
in Autism > 23-3 (April 2019) . - p.584-593
Mots-clés : 25-hydroxyvitamin D autism spectrum disorder early childhood vitamin D Index. décimale : PER Périodiques Résumé : Several studies have suggested an association between vitamin D in childhood and autism spectrum disorder. No prospective studies have evaluated whether lower vitamin D levels precede ASD diagnoses – a necessary condition for causality. The objective of this study was to prospectively evaluate whether vitamin D serum levels in early childhood was associated with incident physician diagnosed ASD. A prospective cohort study was conducted using data from preschool-aged children in the TARGet Kids! practice-based research network in Toronto, Canada, from June 2008 to July 2015. 25-hydroxyvitamin D concentration was measured through blood samples and vitamin D supplementation from parent report. Autism spectrum disorder diagnosis was determined from medical records at follow-up visits. Covariates included age, sex, family history of autism spectrum disorder, maternal ethnicity, and neighborhood household income. Unadjusted and adjusted relative risks and 95% confidence intervals were estimated using Poisson regression with a robust error variance. In this study, 3852 children were included. Autism spectrum disorder diagnosis was identified in 41 children (incidence?=?1.1%) over the observation period (average follow-up time?=?2.5?years). An association between 25-hydroxyvitamin D concentration and autism spectrum disorder was not identified in the unadjusted (relative risk?=?1.04, 95% confidence interval: 0.97, 1.11 per 10?nmol/L increase in 25-hydroxyvitamin D concentration) or adjusted models (adjusted relative risk?=?1.06; 95% confidence interval: 0.95, 1.18). An association between vitamin D supplementation in early childhood and autism spectrum disorder was also not identified (adjusted relative risk?=?0.86, 95% confidence interval: 0.46, 1.62). Vitamin D in early childhood may not be associated with incident physician diagnoses of autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361318756787 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=392