445 recherche sur le mot-clé '3D-perception'

Susceptibility to the Shepard illusion in participants with autism: reduced top-down influences within perception? / Peter MITCHELL in Autism Research, 3-3 (June 2010)  

Public ISBD [article]  inAutism Research > 3-3 (June 2010) . - p.113-119 Titre : Susceptibility to the Shepard illusion in participants with autism: reduced top-down influences within perception? Type de document : texte imprimé Auteurs : Peter MITCHELL, Auteur ; Laurent MOTTRON, Auteur ; Danielle ROPAR, Auteur ; Isabelle SOULIERES, Auteur Année de publication : 2010 Article en page(s) : p.113-119 Langues : Anglais (eng) Mots-clés : low-level-perception visual-illusion 3D-perception Index. décimale : PER Périodiques Résumé : Previous research [Ropar & Mitchell, [2002]] has shown that autistic individuals are somewhat immune to biases induced by top-down processes, particularly the influence of previous knowledge on perception. In order to test this hypothesis within perception, 18 participants with autism who had measured intelligence in the normal range were compared against 18 matched controls in their susceptibility to the Shepard illusion. The illusion consists in misperceiving the shape of a parallelogram in the presence of depth cues. It is attributed [Mitchell, Ropar, Ackroyd, & Rajendran, [2005]] to the effect of top-down constraints within perception. The task involved adjusting a stimulus to the dimensions of a template on a computer screen. Both groups were susceptible to the illusion and the illusion effect was stronger when three-dimensional perspective cues were prominent. Notably, participants with autism were less susceptible to the illusion than typically developing individuals. The findings raise the possibility that in some instances top-down influences are attenuated in individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=107 [article] Susceptibility to the Shepard illusion in participants with autism: reduced top-down influences within perception? [texte imprimé] / Peter MITCHELL, Auteur ; Laurent MOTTRON, Auteur ; Danielle ROPAR, Auteur ; Isabelle SOULIERES, Auteur . - 2010 . - p.113-119. Langues : Anglais (eng) in Autism Research > 3-3 (June 2010) . - p.113-119 Mots-clés : low-level-perception visual-illusion 3D-perception Index. décimale : PER Périodiques Résumé : Previous research [Ropar & Mitchell, [2002]] has shown that autistic individuals are somewhat immune to biases induced by top-down processes, particularly the influence of previous knowledge on perception. In order to test this hypothesis within perception, 18 participants with autism who had measured intelligence in the normal range were compared against 18 matched controls in their susceptibility to the Shepard illusion. The illusion consists in misperceiving the shape of a parallelogram in the presence of depth cues. It is attributed [Mitchell, Ropar, Ackroyd, & Rajendran, [2005]] to the effect of top-down constraints within perception. The task involved adjusting a stimulus to the dimensions of a template on a computer screen. Both groups were susceptible to the illusion and the illusion effect was stronger when three-dimensional perspective cues were prominent. Notably, participants with autism were less susceptible to the illusion than typically developing individuals. The findings raise the possibility that in some instances top-down influences are attenuated in individuals with autism. En ligne : http://dx.doi.org/10.1002/aur.130 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=107

Abilities to Explicitly and Implicitly Infer Intentions from Actions in Adults with Autism Spectrum Disorder / Eleanor J. COLE in Journal of Autism and Developmental Disorders, 48-5 (May 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1712-1726 Titre : Abilities to Explicitly and Implicitly Infer Intentions from Actions in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Eleanor J. COLE, Auteur ; Katie E. SLOCOMBE, Auteur ; Nick E. BARRACLOUGH, Auteur Article en page(s) : p.1712-1726 Langues : Anglais (eng) Mots-clés : Action perception  Autism spectrum disorder  Autistic traits  Eye-tracking  Intentions  Mentalizing Index. décimale : PER Périodiques Résumé : Previous research suggests that Autism Spectrum Disorder (ASD) might be associated with impairments on implicit but not explicit mentalizing tasks. However, such comparisons are made difficult by the heterogeneity of stimuli and the techniques used to measure mentalizing capabilities. We tested the abilities of 34 individuals (17 with ASD) to derive intentions from others' actions during both explicit and implicit tasks and tracked their eye-movements. Adults with ASD displayed explicit but not implicit mentalizing deficits. Adults with ASD displayed typical fixation patterns during both implicit and explicit tasks. These results illustrate an explicit mentalizing deficit in adults with ASD, which cannot be attributed to differences in fixation patterns. En ligne : http://dx.doi.org/10.1007/s10803-017-3425-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355 [article] Abilities to Explicitly and Implicitly Infer Intentions from Actions in Adults with Autism Spectrum Disorder [texte imprimé] / Eleanor J. COLE, Auteur ; Katie E. SLOCOMBE, Auteur ; Nick E. BARRACLOUGH, Auteur . - p.1712-1726. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-5 (May 2018) . - p.1712-1726 Mots-clés : Action perception  Autism spectrum disorder  Autistic traits  Eye-tracking  Intentions  Mentalizing Index. décimale : PER Périodiques Résumé : Previous research suggests that Autism Spectrum Disorder (ASD) might be associated with impairments on implicit but not explicit mentalizing tasks. However, such comparisons are made difficult by the heterogeneity of stimuli and the techniques used to measure mentalizing capabilities. We tested the abilities of 34 individuals (17 with ASD) to derive intentions from others' actions during both explicit and implicit tasks and tracked their eye-movements. Adults with ASD displayed explicit but not implicit mentalizing deficits. Adults with ASD displayed typical fixation patterns during both implicit and explicit tasks. These results illustrate an explicit mentalizing deficit in adults with ASD, which cannot be attributed to differences in fixation patterns. En ligne : http://dx.doi.org/10.1007/s10803-017-3425-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=355

Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome / Xin TAO in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome Type de document : texte imprimé Auteurs : Xin TAO, Auteur ; Katilynne CROOM, Auteur ; Adrian NEWMAN-TANCREDI, Auteur ; Mark VARNEY, Auteur ; Khaleel A. RAZAK, Auteur Langues : Anglais (eng) Mots-clés : Animals  Fragile X Syndrome/physiopathology  Disease Models, Animal  Mice, Knockout  Mice  Fragile X Mental Retardation Protein/genetics  Male  Electroencephalography  Serotonin 5-HT1 Receptor Agonists/pharmacology/administration & dosage  Auditory Perception/drug effects/physiology  Female  Mice, Inbred C57BL  Evoked Potentials, Auditory/drug effects/physiology  5-HT1A receptors  Autism spectrum disorders  Fragile X syndrome  Sensory hypersensitivity  Serotonin  Speech processing  Temporal processing  by Institutional Animal Care and Use Committee at the University of California,  Riverside. Consent for publication: Not applicable. Competing interests: MV &  AN-T are Shareholders in Neurolixis. Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is a leading known genetic cause of intellectual disability and autism spectrum disorders (ASD)-associated behaviors. A consistent and debilitating phenotype of FXS is auditory hypersensitivity that may lead to delayed language and high anxiety. Consistent with findings in FXS human studies, the mouse model of FXS, the Fmr1 knock out (KO) mouse, shows auditory hypersensitivity and temporal processing deficits. In electroencephalograph (EEG) recordings from humans and mice, these deficits manifest as increased N1 amplitudes in event-related potentials (ERP), increased gamma band single trial power (STP) and reduced phase locking to rapid temporal modulations of sound. In our previous study, we found that administration of the selective serotonin-1 A (5-HT(1A))receptor biased agonist, NLX-101, protected Fmr1 KO mice from auditory hypersensitivity-associated seizures. Here we tested the hypothesis that NLX-101 will normalize EEG phenotypes in developing Fmr1 KO mice. METHODS: To test this hypothesis, we examined the effect of NLX-101 on EEG phenotypes in male and female wildtype (WT) and Fmr1 KO mice. Using epidural electrodes, we recorded auditory event related potentials (ERP) and auditory temporal processing with a gap-in-noise auditory steady state response (ASSR) paradigm at two ages, postnatal (P) 21 and 30 days, from both auditory and frontal cortices of awake, freely moving mice, following NLX-101 (at 1.8 mg/kg i.p.) or saline administration. RESULTS: Saline-injected Fmr1 KO mice showed increased N1 amplitudes, increased STP and reduced phase locking to auditory gap-in-noise stimuli versus wild-type mice, reproducing previously published EEG phenotypes. An acute injection of NLX-101 did not alter ERP amplitudes at either P21 or P30, but significantly reduces STP at P30. Inter-trial phase clustering was significantly increased in both age groups with NLX-101, indicating improved temporal processing. The differential effects of serotonin modulation on ERP, background power and temporal processing suggest different developmental mechanisms leading to these phenotypes. CONCLUSIONS: These results suggest that NLX-101 could constitute a promising treatment option for targeting post-synaptic 5-HT(1A) receptors to improve auditory temporal processing, which in turn may improve speech and language function in FXS. En ligne : https://dx.doi.org/10.1186/s11689-024-09587-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Acute administration of NLX-101, a Serotonin 1A receptor agonist, improves auditory temporal processing during development in a mouse model of Fragile X Syndrome [texte imprimé] / Xin TAO, Auteur ; Katilynne CROOM, Auteur ; Adrian NEWMAN-TANCREDI, Auteur ; Mark VARNEY, Auteur ; Khaleel A. RAZAK, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Animals  Fragile X Syndrome/physiopathology  Disease Models, Animal  Mice, Knockout  Mice  Fragile X Mental Retardation Protein/genetics  Male  Electroencephalography  Serotonin 5-HT1 Receptor Agonists/pharmacology/administration & dosage  Auditory Perception/drug effects/physiology  Female  Mice, Inbred C57BL  Evoked Potentials, Auditory/drug effects/physiology  5-HT1A receptors  Autism spectrum disorders  Fragile X syndrome  Sensory hypersensitivity  Serotonin  Speech processing  Temporal processing  by Institutional Animal Care and Use Committee at the University of California,  Riverside. Consent for publication: Not applicable. Competing interests: MV &  AN-T are Shareholders in Neurolixis. Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is a leading known genetic cause of intellectual disability and autism spectrum disorders (ASD)-associated behaviors. A consistent and debilitating phenotype of FXS is auditory hypersensitivity that may lead to delayed language and high anxiety. Consistent with findings in FXS human studies, the mouse model of FXS, the Fmr1 knock out (KO) mouse, shows auditory hypersensitivity and temporal processing deficits. In electroencephalograph (EEG) recordings from humans and mice, these deficits manifest as increased N1 amplitudes in event-related potentials (ERP), increased gamma band single trial power (STP) and reduced phase locking to rapid temporal modulations of sound. In our previous study, we found that administration of the selective serotonin-1 A (5-HT(1A))receptor biased agonist, NLX-101, protected Fmr1 KO mice from auditory hypersensitivity-associated seizures. Here we tested the hypothesis that NLX-101 will normalize EEG phenotypes in developing Fmr1 KO mice. METHODS: To test this hypothesis, we examined the effect of NLX-101 on EEG phenotypes in male and female wildtype (WT) and Fmr1 KO mice. Using epidural electrodes, we recorded auditory event related potentials (ERP) and auditory temporal processing with a gap-in-noise auditory steady state response (ASSR) paradigm at two ages, postnatal (P) 21 and 30 days, from both auditory and frontal cortices of awake, freely moving mice, following NLX-101 (at 1.8 mg/kg i.p.) or saline administration. RESULTS: Saline-injected Fmr1 KO mice showed increased N1 amplitudes, increased STP and reduced phase locking to auditory gap-in-noise stimuli versus wild-type mice, reproducing previously published EEG phenotypes. An acute injection of NLX-101 did not alter ERP amplitudes at either P21 or P30, but significantly reduces STP at P30. Inter-trial phase clustering was significantly increased in both age groups with NLX-101, indicating improved temporal processing. The differential effects of serotonin modulation on ERP, background power and temporal processing suggest different developmental mechanisms leading to these phenotypes. CONCLUSIONS: These results suggest that NLX-101 could constitute a promising treatment option for targeting post-synaptic 5-HT(1A) receptors to improve auditory temporal processing, which in turn may improve speech and language function in FXS. En ligne : https://dx.doi.org/10.1186/s11689-024-09587-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Adaptation to different communicative contexts: an eye tracking study of autistic adults / Julia PARISH-MORRIS in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 5 p. Titre : Adaptation to different communicative contexts: an eye tracking study of autistic adults Type de document : texte imprimé Auteurs : Julia PARISH-MORRIS, Auteur ; Ashley A. PALLATHRA, Auteur ; Emily FERGUSON, Auteur ; Brenna B. MADDOX, Auteur ; Alison POMYKACZ, Auteur ; Leat PEREZ, Auteur ; Leila BATEMAN, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Edward S. BRODKIN, Auteur Article en page(s) : 5 p. Langues : Anglais (eng) Mots-clés : Adults  Autism spectrum disorder  Eye gaze  Face processing/perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Learning through social observation (i.e., watching other people interact) lays the foundation for later social skills and social cognition. However, social situations are often complex, and humans are only capable of attending to one aspect of a scene at a time. How do people choose where to allocate their visual resources when viewing complex social scenarios? For typically developing (TD) individuals, faces are often given priority. Depending upon context, however, it may be more useful to attend to other aspects of the environment, such as hands, tools, or background objects. Previous studies reported reduced face looking in individuals with autism spectrum disorder (ASD), but modulation of visual attention in response to contextual differences (e.g., according to social richness, or the presence/absence of communicative behaviors between two people) has only briefly been explored. In this study, we used eye-tracking technology to test the extent to which ASD adults and TD adults use social context to guide their gaze behavior. METHODS: Fifty-five adults participated (28 with ASD). The location and duration of participants' gaze were recorded while they watched a series of naturalistic social videos. Half of the videos depicted two people engaging in non-verbal communication (rich social scenes) while playing with toys. The other half depicted two people playing with toys separately, not interacting with each other (lean social scenes). RESULTS: ASD and TD adults both increased their attention to faces in communicative contexts (rich social scenes) as compared to non-communicative contexts (lean social scenes). However, TD adults increased their attention to faces significantly more when watching two people communicate than did ASD adults, who increased their attention to a lesser degree. Further analysis revealed that ASD adults persisted in looking at hands and toys, even when observing two people communicate in a rich social scene. CONCLUSIONS: Diminished gaze to faces when observing two people communicating may lead to fewer opportunities for social learning and subsequent reductions in social knowledge. Naturalistic measures of contextual modulation could help identify areas of need for individuals learning about the social world and could become treatment targets to improve everyday social learning. En ligne : https://dx.doi.org/10.1186/s11689-019-9265-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Adaptation to different communicative contexts: an eye tracking study of autistic adults [texte imprimé] / Julia PARISH-MORRIS, Auteur ; Ashley A. PALLATHRA, Auteur ; Emily FERGUSON, Auteur ; Brenna B. MADDOX, Auteur ; Alison POMYKACZ, Auteur ; Leat PEREZ, Auteur ; Leila BATEMAN, Auteur ; Juhi PANDEY, Auteur ; Robert T. SCHULTZ, Auteur ; Edward S. BRODKIN, Auteur . - 5 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 5 p. Mots-clés : Adults  Autism spectrum disorder  Eye gaze  Face processing/perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Learning through social observation (i.e., watching other people interact) lays the foundation for later social skills and social cognition. However, social situations are often complex, and humans are only capable of attending to one aspect of a scene at a time. How do people choose where to allocate their visual resources when viewing complex social scenarios? For typically developing (TD) individuals, faces are often given priority. Depending upon context, however, it may be more useful to attend to other aspects of the environment, such as hands, tools, or background objects. Previous studies reported reduced face looking in individuals with autism spectrum disorder (ASD), but modulation of visual attention in response to contextual differences (e.g., according to social richness, or the presence/absence of communicative behaviors between two people) has only briefly been explored. In this study, we used eye-tracking technology to test the extent to which ASD adults and TD adults use social context to guide their gaze behavior. METHODS: Fifty-five adults participated (28 with ASD). The location and duration of participants' gaze were recorded while they watched a series of naturalistic social videos. Half of the videos depicted two people engaging in non-verbal communication (rich social scenes) while playing with toys. The other half depicted two people playing with toys separately, not interacting with each other (lean social scenes). RESULTS: ASD and TD adults both increased their attention to faces in communicative contexts (rich social scenes) as compared to non-communicative contexts (lean social scenes). However, TD adults increased their attention to faces significantly more when watching two people communicate than did ASD adults, who increased their attention to a lesser degree. Further analysis revealed that ASD adults persisted in looking at hands and toys, even when observing two people communicate in a rich social scene. CONCLUSIONS: Diminished gaze to faces when observing two people communicating may lead to fewer opportunities for social learning and subsequent reductions in social knowledge. Naturalistic measures of contextual modulation could help identify areas of need for individuals learning about the social world and could become treatment targets to improve everyday social learning. En ligne : https://dx.doi.org/10.1186/s11689-019-9265-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

Adaptation to the Speed of Biological Motion in Autism / Themis KARAMINIS in Journal of Autism and Developmental Disorders, 50-2 (February 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.373-385 Titre : Adaptation to the Speed of Biological Motion in Autism Type de document : texte imprimé Auteurs : Themis KARAMINIS, Auteur ; Roberto ARRIGHI, Auteur ; Georgia FORTH, Auteur ; David BURR, Auteur ; Elizabeth PELLICANO, Auteur Article en page(s) : p.373-385 Langues : Anglais (eng) Mots-clés : Adaptation  Autism  Biological motion  Perception  Running speed Index. décimale : PER Périodiques Résumé : Autistic individuals often present atypicalities in adaptation-the continuous recalibration of perceptual systems driven by recent sensory experiences. Here, we examined such atypicalities in human biological motion. We used a dual-task paradigm, including a running-speed discrimination task ('comparing the speed of two running silhouettes') and a change-detection task ('detecting fixation-point shrinkages') assessing attention. We tested 19 school-age autistic and 19 age- and ability-matched typical participants, also recording eye-movements. The two groups presented comparable speed-discrimination abilities and, unexpectedly, comparable adaptation. Accuracy in the change-detection task and the scatter of eye-fixations around the fixation point were also similar across groups. Yet, the scatter of fixations reliably predicted the magnitude of adaptation, demonstrating the importance of controlling for attention in adaptation studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04241-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] Adaptation to the Speed of Biological Motion in Autism [texte imprimé] / Themis KARAMINIS, Auteur ; Roberto ARRIGHI, Auteur ; Georgia FORTH, Auteur ; David BURR, Auteur ; Elizabeth PELLICANO, Auteur . - p.373-385. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.373-385 Mots-clés : Adaptation  Autism  Biological motion  Perception  Running speed Index. décimale : PER Périodiques Résumé : Autistic individuals often present atypicalities in adaptation-the continuous recalibration of perceptual systems driven by recent sensory experiences. Here, we examined such atypicalities in human biological motion. We used a dual-task paradigm, including a running-speed discrimination task ('comparing the speed of two running silhouettes') and a change-detection task ('detecting fixation-point shrinkages') assessing attention. We tested 19 school-age autistic and 19 age- and ability-matched typical participants, also recording eye-movements. The two groups presented comparable speed-discrimination abilities and, unexpectedly, comparable adaptation. Accuracy in the change-detection task and the scatter of eye-fixations around the fixation point were also similar across groups. Yet, the scatter of fixations reliably predicted the magnitude of adaptation, demonstrating the importance of controlling for attention in adaptation studies. En ligne : http://dx.doi.org/10.1007/s10803-019-04241-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

Adults’ Versus Children’s Perceptions of a Child with Autism or Attention Deficit Hyperactivity Disorder / Marsha HARNUM in Journal of Autism and Developmental Disorders, 37-7 (August 2007)  

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Adults with Autism Tend to Undermine the Hidden Environmental Structure: Evidence from a Visual Associative Learning Task / Laurie-Anne SAPEY-TRIOMPHE in Journal of Autism and Developmental Disorders, 48-9 (September 2018)  

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Age and Sensory Processing Abnormalities Predict Declines in Encoding and Recall of Temporally Manipulated Speech in High-Functioning Adults with ASD / Jennifer L. MAYER in Autism Research, 7-1 (February 2014)  

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Age-Related Changes in Conjunctive Visual Search in Children with and without ASD / Grace IAROCCI in Autism Research, 7-2 (April 2014)  

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Alexithymia, but not autism spectrum disorder, may be related to the production of emotional facial expressions / Dominic A. TREVISAN in Molecular Autism, 7 (2016)  

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