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Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism: a meta-analysis of neuroimaging studies / Melody M. Y. CHAN in Molecular Autism, 11 (2020)
[article]
Titre : Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism: a meta-analysis of neuroimaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Melody M. Y. CHAN, Auteur ; Yvonne M. Y. HAN, Auteur Article en page(s) : 72 p. Langues : Anglais (eng) Mots-clés : Action observation Autism Es-sdm Emotion Meta-analysis Mirror neuron fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Impaired imitation has been found to be an important factor contributing to social communication deficits in individuals with autism spectrum disorder (ASD). It has been hypothesized that the neural correlate of imitation, the mirror neuron system (MNS), is dysfunctional in ASD, resulting in imitation impairment as one of the key behavioral manifestations in ASD. Previous MNS studies produced inconsistent results, leaving the debate of whether "broken" mirror neurons in ASD are unresolved. METHODS: This meta-analysis aimed to explore the differences in MNS activation patterns between typically developing (TD) and ASD individuals when they observe biological motions with or without social-emotional components. Effect size signed differential mapping (ES-SDM) was adopted to synthesize the available fMRI data. RESULTS: ES-SDM analysis revealed hyperactivation in the right inferior frontal gyrus and left supplementary motor area in ASD during observation of biological motions. Subgroup analysis of experiments involving the observation of stimuli with or without emotional component revealed hyperactivation in the left inferior parietal lobule and left supplementary motor during action observation without emotional components, whereas hyperactivation of the right inferior frontal gyrus was found during action observation with emotional components in ASD. Subgroup analyses of age showed hyperactivation of the bilateral inferior frontal gyrus in ASD adolescents, while hyperactivation in the right inferior frontal gyrus was noted in ASD adults. Meta-regression within ASD individuals indicated that the right cerebellum crus I activation increased with age, while the left inferior temporal gyrus activation decreased with age. LIMITATIONS: This meta-analysis is limited in its generalization of the findings to individuals with ASD by the restricted age range, heterogeneous study sample, and the large within-group variation in MNS activation patterns during object observation. Furthermore, we only included action observation studies which might limit the generalization of our results to the imitation deficits in ASD. In addition, the relatively small sample size for individual studies might also potentially overestimate the effect sizes. CONCLUSION: The MNS is impaired in ASD. The abnormal activation patterns were found to be modulated by the nature of stimuli and age, which might explain the contradictory results from earlier studies on the "broken mirror neuron" debate. En ligne : http://dx.doi.org/10.1186/s13229-020-00374-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433
in Molecular Autism > 11 (2020) . - 72 p.[article] Differential mirror neuron system (MNS) activation during action observation with and without social-emotional components in autism: a meta-analysis of neuroimaging studies [Texte imprimé et/ou numérique] / Melody M. Y. CHAN, Auteur ; Yvonne M. Y. HAN, Auteur . - 72 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 72 p.
Mots-clés : Action observation Autism Es-sdm Emotion Meta-analysis Mirror neuron fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Impaired imitation has been found to be an important factor contributing to social communication deficits in individuals with autism spectrum disorder (ASD). It has been hypothesized that the neural correlate of imitation, the mirror neuron system (MNS), is dysfunctional in ASD, resulting in imitation impairment as one of the key behavioral manifestations in ASD. Previous MNS studies produced inconsistent results, leaving the debate of whether "broken" mirror neurons in ASD are unresolved. METHODS: This meta-analysis aimed to explore the differences in MNS activation patterns between typically developing (TD) and ASD individuals when they observe biological motions with or without social-emotional components. Effect size signed differential mapping (ES-SDM) was adopted to synthesize the available fMRI data. RESULTS: ES-SDM analysis revealed hyperactivation in the right inferior frontal gyrus and left supplementary motor area in ASD during observation of biological motions. Subgroup analysis of experiments involving the observation of stimuli with or without emotional component revealed hyperactivation in the left inferior parietal lobule and left supplementary motor during action observation without emotional components, whereas hyperactivation of the right inferior frontal gyrus was found during action observation with emotional components in ASD. Subgroup analyses of age showed hyperactivation of the bilateral inferior frontal gyrus in ASD adolescents, while hyperactivation in the right inferior frontal gyrus was noted in ASD adults. Meta-regression within ASD individuals indicated that the right cerebellum crus I activation increased with age, while the left inferior temporal gyrus activation decreased with age. LIMITATIONS: This meta-analysis is limited in its generalization of the findings to individuals with ASD by the restricted age range, heterogeneous study sample, and the large within-group variation in MNS activation patterns during object observation. Furthermore, we only included action observation studies which might limit the generalization of our results to the imitation deficits in ASD. In addition, the relatively small sample size for individual studies might also potentially overestimate the effect sizes. CONCLUSION: The MNS is impaired in ASD. The abnormal activation patterns were found to be modulated by the nature of stimuli and age, which might explain the contradictory results from earlier studies on the "broken mirror neuron" debate. En ligne : http://dx.doi.org/10.1186/s13229-020-00374-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 Motor network activation during human action observation and imagery: Mu rhythm EEG evidence on typical and atypical neurodevelopment / Olivia Morgan LAPENTA in Research in Autism Spectrum Disorders, 8-7 (July 2014)
[article]
Titre : Motor network activation during human action observation and imagery: Mu rhythm EEG evidence on typical and atypical neurodevelopment Type de document : Texte imprimé et/ou numérique Auteurs : Olivia Morgan LAPENTA, Auteur ; Paulo Sérgio BOGGIO, Auteur Article en page(s) : p.759-766 Langues : Anglais (eng) Mots-clés : Motor imagery Action observation Mu rhythm Mirror neuron system Autism EEG Index. décimale : PER Périodiques Résumé : Abstract The mental simulation theory suggests activation of the motor network during imagery and observation of human movements, similarly to the activation during action execution and is proposed to be mediated by the mirror neuron system. This activation can be measured by several technologies such as electroencephalography, magnetoencephalography, functional magnetic resonance imaging and positron emission tomography. It is proposed that motor network activation and therefore increased cortical excitability of primary motor cortex occur due to premotor mirror neuron system inputs. This mechanism has been demonstrated as important for planning actions and seems relevant for anticipating others actions and for empathy establishing as well as for language development. In this review we focused on studies relative to electroencephalography data of motor neural network activation during movement observation and imagery in typical and atypical development. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.759-766[article] Motor network activation during human action observation and imagery: Mu rhythm EEG evidence on typical and atypical neurodevelopment [Texte imprimé et/ou numérique] / Olivia Morgan LAPENTA, Auteur ; Paulo Sérgio BOGGIO, Auteur . - p.759-766.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-7 (July 2014) . - p.759-766
Mots-clés : Motor imagery Action observation Mu rhythm Mirror neuron system Autism EEG Index. décimale : PER Périodiques Résumé : Abstract The mental simulation theory suggests activation of the motor network during imagery and observation of human movements, similarly to the activation during action execution and is proposed to be mediated by the mirror neuron system. This activation can be measured by several technologies such as electroencephalography, magnetoencephalography, functional magnetic resonance imaging and positron emission tomography. It is proposed that motor network activation and therefore increased cortical excitability of primary motor cortex occur due to premotor mirror neuron system inputs. This mechanism has been demonstrated as important for planning actions and seems relevant for anticipating others actions and for empathy establishing as well as for language development. In this review we focused on studies relative to electroencephalography data of motor neural network activation during movement observation and imagery in typical and atypical development. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.03.019 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 Broken or socially mistuned mirroring in ASD? An investigation via transcranial magnetic stimulation / Jellina PRINSEN in Autism Research, 15-6 (June 2022)
[article]
Titre : Broken or socially mistuned mirroring in ASD? An investigation via transcranial magnetic stimulation Type de document : Texte imprimé et/ou numérique Auteurs : Jellina PRINSEN, Auteur ; Kaat ALAERTS, Auteur Article en page(s) : p.1056-1067 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder Brain Hand/physiology Humans Transcranial Magnetic Stimulation action observation eye contact mirror system Index. décimale : PER Périodiques Résumé : Individuals with an autism spectrum disorder (ASD) experience persistent difficulties during social interactions and communication. Previously, it has been suggested that deficits in the so-called "mirror system," active during both action execution and observation, may underlie these social difficulties. It is still a topic of debate however whether deficiencies in the simulation of others' actions (i.e., "broken" mirroring) forms a general feature of ASD, or whether these mostly reflect a lack of social attunement. The latter would suggest an overall intact mirror system, but an impaired modulation of mirror activity according to variable social contexts. In this study, 25 adults with ASD and 28 age- and IQ-matched control participants underwent transcranial magnetic stimulation during the observation of hand movements under variable conditions. Hand movements were presented via a live interaction partner, either without social context to assess basic motor mirroring or in combination with direct and averted gaze from the actor to assess socially modulated mirroring. Overall, no significant group differences were revealed, indicating no generally diminished mirror activity in ASD. Interestingly however, regression analyses revealed that, among ASD participants, higher symptom severity was associated with both reduced basic motor mirroring and aberrant socially modulated mirroring (i.e., no enhancement of mirror system activity upon observation of the interaction partner's direct vs. averted gaze). These findings further challenge the notion that mirror system dysfunctions constitute a principal feature of ASD, but demonstrate that variations in mirroring may be related to differential expressions of ASD symptom severity. LAY SUMMARY: Our findings show similar activity levels in brain regions responsible for action simulation and understanding in adults with autism, compared to adults without autism. However, the presence of more severe autism symptoms was linked to reduced activity in these regions. This suggests lower levels of brain activity during action understanding in some, but not all, persons with autism, which may contribute to the social difficulties these persons experience in daily life. En ligne : http://dx.doi.org/10.1002/aur.2720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476
in Autism Research > 15-6 (June 2022) . - p.1056-1067[article] Broken or socially mistuned mirroring in ASD? An investigation via transcranial magnetic stimulation [Texte imprimé et/ou numérique] / Jellina PRINSEN, Auteur ; Kaat ALAERTS, Auteur . - p.1056-1067.
Langues : Anglais (eng)
in Autism Research > 15-6 (June 2022) . - p.1056-1067
Mots-clés : Adult Autism Spectrum Disorder Autistic Disorder Brain Hand/physiology Humans Transcranial Magnetic Stimulation action observation eye contact mirror system Index. décimale : PER Périodiques Résumé : Individuals with an autism spectrum disorder (ASD) experience persistent difficulties during social interactions and communication. Previously, it has been suggested that deficits in the so-called "mirror system," active during both action execution and observation, may underlie these social difficulties. It is still a topic of debate however whether deficiencies in the simulation of others' actions (i.e., "broken" mirroring) forms a general feature of ASD, or whether these mostly reflect a lack of social attunement. The latter would suggest an overall intact mirror system, but an impaired modulation of mirror activity according to variable social contexts. In this study, 25 adults with ASD and 28 age- and IQ-matched control participants underwent transcranial magnetic stimulation during the observation of hand movements under variable conditions. Hand movements were presented via a live interaction partner, either without social context to assess basic motor mirroring or in combination with direct and averted gaze from the actor to assess socially modulated mirroring. Overall, no significant group differences were revealed, indicating no generally diminished mirror activity in ASD. Interestingly however, regression analyses revealed that, among ASD participants, higher symptom severity was associated with both reduced basic motor mirroring and aberrant socially modulated mirroring (i.e., no enhancement of mirror system activity upon observation of the interaction partner's direct vs. averted gaze). These findings further challenge the notion that mirror system dysfunctions constitute a principal feature of ASD, but demonstrate that variations in mirroring may be related to differential expressions of ASD symptom severity. LAY SUMMARY: Our findings show similar activity levels in brain regions responsible for action simulation and understanding in adults with autism, compared to adults without autism. However, the presence of more severe autism symptoms was linked to reduced activity in these regions. This suggests lower levels of brain activity during action understanding in some, but not all, persons with autism, which may contribute to the social difficulties these persons experience in daily life. En ligne : http://dx.doi.org/10.1002/aur.2720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476