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Brief Report: The Use of Self-Report Measures in Young People with Autism Spectrum Disorder to Access Symptoms of Anxiety, Depression and Negative Thoughts / Ann OZSIVADJIAN in Journal of Autism and Developmental Disorders, 44-4 (April 2014)
[article]
Titre : Brief Report: The Use of Self-Report Measures in Young People with Autism Spectrum Disorder to Access Symptoms of Anxiety, Depression and Negative Thoughts Type de document : Texte imprimé et/ou numérique Auteurs : Ann OZSIVADJIAN, Auteur ; Charlotte HIBBERD, Auteur ; Matthew J. HOLLOCKS, Auteur Année de publication : 2014 Article en page(s) : p.969-974 Langues : Anglais (eng) Mots-clés : Affective disorders Anxiety disorders Cognition Cognitive behavioral therapy Emotion Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The aims of this study were two-fold; firstly, to investigate whether self-report measures are useful and reflect parent-reported psychiatric symptoms in children with autism spectrum disorder (ASD), and secondly, to investigate whether children with ASD are able to access and report their cognitions, a prerequisite skill for cognitive behavior therapies. Thirty children with ASD and 21 comparison children without ASD completed the Spence Children’s Anxiety Scale and the Children’s Depression Inventory, with parents completing the parent version of both questionnaires. Intraclass correlations revealed that there was good agreement between ASD children and their parents on both measures, but only on the depression measure in non-ASD children. The children in both groups also completed the Children’s Automatic Thoughts Questionnaires; multiple regression analyses indicated that within the ASD group, child-rated scores on the CATS questionnaire were positively related to increased self-reported symptoms of anxiety and depression, but not in the comparison group, suggesting that children with ASD are able to accurately report their anxious and depressed cognitions. The implications of these results for both the practice and theory of CBT for children with ASD are discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1937-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.969-974[article] Brief Report: The Use of Self-Report Measures in Young People with Autism Spectrum Disorder to Access Symptoms of Anxiety, Depression and Negative Thoughts [Texte imprimé et/ou numérique] / Ann OZSIVADJIAN, Auteur ; Charlotte HIBBERD, Auteur ; Matthew J. HOLLOCKS, Auteur . - 2014 . - p.969-974.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-4 (April 2014) . - p.969-974
Mots-clés : Affective disorders Anxiety disorders Cognition Cognitive behavioral therapy Emotion Neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : The aims of this study were two-fold; firstly, to investigate whether self-report measures are useful and reflect parent-reported psychiatric symptoms in children with autism spectrum disorder (ASD), and secondly, to investigate whether children with ASD are able to access and report their cognitions, a prerequisite skill for cognitive behavior therapies. Thirty children with ASD and 21 comparison children without ASD completed the Spence Children’s Anxiety Scale and the Children’s Depression Inventory, with parents completing the parent version of both questionnaires. Intraclass correlations revealed that there was good agreement between ASD children and their parents on both measures, but only on the depression measure in non-ASD children. The children in both groups also completed the Children’s Automatic Thoughts Questionnaires; multiple regression analyses indicated that within the ASD group, child-rated scores on the CATS questionnaire were positively related to increased self-reported symptoms of anxiety and depression, but not in the comparison group, suggesting that children with ASD are able to accurately report their anxious and depressed cognitions. The implications of these results for both the practice and theory of CBT for children with ASD are discussed. En ligne : http://dx.doi.org/10.1007/s10803-013-1937-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=228 A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms / Robin F. CHAN in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)
[article]
Titre : A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Robin F. CHAN, Auteur ; William E. COPELAND, Auteur ; Min ZHAO, Auteur ; Lin Y. XIE, Auteur ; Jane COSTELLO, Auteur ; Karolina A. ABERG, Auteur ; Edwin J. C. G. VAN DEN OORD, Auteur Article en page(s) : p.802-809 Langues : Anglais (eng) Mots-clés : Brain DNA Methylation Depression/genetics Female Genome-Wide Association Study Humans Male Puberty Sex Characteristics Affective disorders biomarkers epigenetics sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Women are 1.5-3 times more likely to suffer from depression than men. This sex bias first emerges during puberty and then persists across the reproductive years. As the cause remains largely elusive, we performed a methylation-wide association study (MWAS) to generate novel hypotheses. METHODS: We assayed nearly all 28 million possible methylation sites in blood in 595 blood samples from 487 participants aged 9-17. MWASs were performed to identify methylation sites associated with increasing sex differences in depression symptoms as a function of pubertal stage. Epigenetic deconvolution was applied to perform analyses on a cell-type specific level. RESULTS: In monocytes, a substantial number of significant associations were detected after controlling the FDR at 0.05. These results could not be explained by plasma testosterone/estradiol or current/lifetime trauma. Our top results in monocytes were significantly enriched (ratio of 2.48) for genes in the top of a large genome-wide association study (GWAS) meta-analysis of depression and neurodevelopment-related Gene Ontology (GO) terms that remained significant after correcting for multiple testing. Focusing on our most robust findings (70 genes overlapping with the GWAS meta-analysis and the significant GO terms), we find genes coding for members of each of the major classes of axon guidance molecules (netrins, slits, semaphorins, ephrins, and cell adhesion molecules). Many of these genes were previously implicated in rodent studies of brain development and depression-like phenotypes, as well as human methylation, gene expression and GWAS studies. CONCLUSIONS: Our study suggests that the emergence of sex differences in depression may be related to the differential rewiring of brain circuits between boys and girls during puberty. En ligne : http://dx.doi.org/10.1111/jcpp.13522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.802-809[article] A methylation study implicates the rewiring of brain neural circuits during puberty in the emergence of sex differences in depression symptoms [Texte imprimé et/ou numérique] / Robin F. CHAN, Auteur ; William E. COPELAND, Auteur ; Min ZHAO, Auteur ; Lin Y. XIE, Auteur ; Jane COSTELLO, Auteur ; Karolina A. ABERG, Auteur ; Edwin J. C. G. VAN DEN OORD, Auteur . - p.802-809.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.802-809
Mots-clés : Brain DNA Methylation Depression/genetics Female Genome-Wide Association Study Humans Male Puberty Sex Characteristics Affective disorders biomarkers epigenetics sex differences Index. décimale : PER Périodiques Résumé : BACKGROUND: Women are 1.5-3 times more likely to suffer from depression than men. This sex bias first emerges during puberty and then persists across the reproductive years. As the cause remains largely elusive, we performed a methylation-wide association study (MWAS) to generate novel hypotheses. METHODS: We assayed nearly all 28 million possible methylation sites in blood in 595 blood samples from 487 participants aged 9-17. MWASs were performed to identify methylation sites associated with increasing sex differences in depression symptoms as a function of pubertal stage. Epigenetic deconvolution was applied to perform analyses on a cell-type specific level. RESULTS: In monocytes, a substantial number of significant associations were detected after controlling the FDR at 0.05. These results could not be explained by plasma testosterone/estradiol or current/lifetime trauma. Our top results in monocytes were significantly enriched (ratio of 2.48) for genes in the top of a large genome-wide association study (GWAS) meta-analysis of depression and neurodevelopment-related Gene Ontology (GO) terms that remained significant after correcting for multiple testing. Focusing on our most robust findings (70 genes overlapping with the GWAS meta-analysis and the significant GO terms), we find genes coding for members of each of the major classes of axon guidance molecules (netrins, slits, semaphorins, ephrins, and cell adhesion molecules). Many of these genes were previously implicated in rodent studies of brain development and depression-like phenotypes, as well as human methylation, gene expression and GWAS studies. CONCLUSIONS: Our study suggests that the emergence of sex differences in depression may be related to the differential rewiring of brain circuits between boys and girls during puberty. En ligne : http://dx.doi.org/10.1111/jcpp.13522 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477