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Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity / C. C. DOUGHERTY in Molecular Autism, 7 (2016)
[article]
Titre : Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity Type de document : Texte imprimé et/ou numérique Auteurs : C. C. DOUGHERTY, Auteur ; D. W. EVANS, Auteur ; G. J. KATUWAL, Auteur ; A. M. MICHAEL, Auteur Article en page(s) : 28p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Algorithms Autism Spectrum Disorder/diagnostic imaging/pathology Child Cross-Sectional Studies Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Severity of Illness Index Temporal Lobe/anatomy & histology Young Adult Asymmetry Autism spectrum disorder Development Fusiform gyrus Structural imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: While asymmetry in the fusiform gyrus (FFG) has been reported in functional and structural studies in typically developing controls (TDC), few studies have examined FFG asymmetry in autism spectrum disorder (ASD) subjects and those studies are limited by small sample sizes, and confounded by cognitive ability or handedness. No previous work has examined FFG surface area or cortical thickness asymmetry in ASD; nor do we understand the trajectory of FFG asymmetry over time. Finally, it is not known how FFG structural asymmetry relates to ASD symptom severity. METHODS: In this study, we examined FFG volume, surface area, and cortical thickness asymmetry, as well as their cross-sectional trajectories in a large sample of right-handed males aged 7 to 25 years with 128 ASD and 127 TDC subjects using general linear models. In addition, we examined the relationship between FFG asymmetry and ASD severity using the Autism Diagnostic Observation Schedule (ADOS) and Gotham autism severity scores. RESULTS: Findings revealed that while group differences were evident with mean leftward asymmetry in ASD and mean near symmetry in TDC volume and surface area, asymmetry for both groups existed on a spectrum encompassing leftward and rightward asymmetry. In ASD subjects, volume asymmetry was negatively associated with ADOS and autism severity score symptom measures, with a subset of rightward asymmetric patients being most severely affected. We also observed differential trajectory of surface area asymmetry: ASD subjects exhibited a change from leftward asymmetry toward symmetry from age 7 to 25, whereas TDCs exhibited the reverse trend with a change from near symmetry toward leftward symmetry over the observed age range. CONCLUSIONS: Abnormalities in FFG structural asymmetry are related to symptom severity in ASD and show differential developmental trajectory compared to TDC. This study is the first to note these findings. These results may have important implications for understanding the role of FFG asymmetry in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0089-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328
in Molecular Autism > 7 (2016) . - 28p.[article] Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity [Texte imprimé et/ou numérique] / C. C. DOUGHERTY, Auteur ; D. W. EVANS, Auteur ; G. J. KATUWAL, Auteur ; A. M. MICHAEL, Auteur . - 28p.
Langues : Anglais (eng)
in Molecular Autism > 7 (2016) . - 28p.
Mots-clés : Adolescent Adult Algorithms Autism Spectrum Disorder/diagnostic imaging/pathology Child Cross-Sectional Studies Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Severity of Illness Index Temporal Lobe/anatomy & histology Young Adult Asymmetry Autism spectrum disorder Development Fusiform gyrus Structural imaging Index. décimale : PER Périodiques Résumé : BACKGROUND: While asymmetry in the fusiform gyrus (FFG) has been reported in functional and structural studies in typically developing controls (TDC), few studies have examined FFG asymmetry in autism spectrum disorder (ASD) subjects and those studies are limited by small sample sizes, and confounded by cognitive ability or handedness. No previous work has examined FFG surface area or cortical thickness asymmetry in ASD; nor do we understand the trajectory of FFG asymmetry over time. Finally, it is not known how FFG structural asymmetry relates to ASD symptom severity. METHODS: In this study, we examined FFG volume, surface area, and cortical thickness asymmetry, as well as their cross-sectional trajectories in a large sample of right-handed males aged 7 to 25 years with 128 ASD and 127 TDC subjects using general linear models. In addition, we examined the relationship between FFG asymmetry and ASD severity using the Autism Diagnostic Observation Schedule (ADOS) and Gotham autism severity scores. RESULTS: Findings revealed that while group differences were evident with mean leftward asymmetry in ASD and mean near symmetry in TDC volume and surface area, asymmetry for both groups existed on a spectrum encompassing leftward and rightward asymmetry. In ASD subjects, volume asymmetry was negatively associated with ADOS and autism severity score symptom measures, with a subset of rightward asymmetric patients being most severely affected. We also observed differential trajectory of surface area asymmetry: ASD subjects exhibited a change from leftward asymmetry toward symmetry from age 7 to 25, whereas TDCs exhibited the reverse trend with a change from near symmetry toward leftward symmetry over the observed age range. CONCLUSIONS: Abnormalities in FFG structural asymmetry are related to symptom severity in ASD and show differential developmental trajectory compared to TDC. This study is the first to note these findings. These results may have important implications for understanding the role of FFG asymmetry in ASD. En ligne : http://dx.doi.org/10.1186/s13229-016-0089-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders / Amy Vaughan VAN HECKE in Journal of Autism and Developmental Disorders, 45-2 (February 2015)
[article]
Titre : Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Amy Vaughan VAN HECKE, Auteur ; Sheryl STEVENS, Auteur ; Audrey M. CARSON, Auteur ; Jeffrey S. KARST, Auteur ; Bridget DOLAN, Auteur ; Kirsten SCHOHL, Auteur ; Ryan J. MCKINDLES, Auteur ; Rheanna REMMEL, Auteur ; Scott BROCKMAN, Auteur Article en page(s) : p.316-335 Langues : Anglais (eng) Mots-clés : Autism Adolescence EEG Asymmetry PEERS Intervention Brain Plasticity Index. décimale : PER Périodiques Résumé : This study examined whether the Program for the Education and Enrichment of Relational Skills (PEERS: Social skills for teenagers with developmental and autism spectrum disorders: The PEERS treatment manual, Routledge, New York, 2010a) affected neural function, via EEG asymmetry, in a randomized controlled trial of adolescents with Autism spectrum disorders (ASD) and a group of typically developing adolescents. Adolescents with ASD in PEERS shifted from right-hemisphere gamma-band EEG asymmetry before PEERS to left-hemisphere EEG asymmetry after PEERS, versus a waitlist ASD group. Left-hemisphere EEG asymmetry was associated with more social contacts and knowledge, and fewer symptoms of autism. Adolescents with ASD in PEERS no longer differed from typically developing adolescents in left-dominant EEG asymmetry at post-test. These findings are discussed via the Modifier Model of Autism (Mundy et al. in Res Pract Persons Severe Disabl 32(2):124, 2007), with emphasis on remediating isolation/withdrawal in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1883-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.316-335[article] Measuring the Plasticity of Social Approach: A Randomized Controlled Trial of the Effects of the PEERS Intervention on EEG Asymmetry in Adolescents with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Amy Vaughan VAN HECKE, Auteur ; Sheryl STEVENS, Auteur ; Audrey M. CARSON, Auteur ; Jeffrey S. KARST, Auteur ; Bridget DOLAN, Auteur ; Kirsten SCHOHL, Auteur ; Ryan J. MCKINDLES, Auteur ; Rheanna REMMEL, Auteur ; Scott BROCKMAN, Auteur . - p.316-335.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.316-335
Mots-clés : Autism Adolescence EEG Asymmetry PEERS Intervention Brain Plasticity Index. décimale : PER Périodiques Résumé : This study examined whether the Program for the Education and Enrichment of Relational Skills (PEERS: Social skills for teenagers with developmental and autism spectrum disorders: The PEERS treatment manual, Routledge, New York, 2010a) affected neural function, via EEG asymmetry, in a randomized controlled trial of adolescents with Autism spectrum disorders (ASD) and a group of typically developing adolescents. Adolescents with ASD in PEERS shifted from right-hemisphere gamma-band EEG asymmetry before PEERS to left-hemisphere EEG asymmetry after PEERS, versus a waitlist ASD group. Left-hemisphere EEG asymmetry was associated with more social contacts and knowledge, and fewer symptoms of autism. Adolescents with ASD in PEERS no longer differed from typically developing adolescents in left-dominant EEG asymmetry at post-test. These findings are discussed via the Modifier Model of Autism (Mundy et al. in Res Pract Persons Severe Disabl 32(2):124, 2007), with emphasis on remediating isolation/withdrawal in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1883-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited / Dorothea L. FLORIS in Journal of Autism and Developmental Disorders, 43-8 (August 2013)
[article]
Titre : Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited Type de document : Texte imprimé et/ou numérique Auteurs : Dorothea L. FLORIS, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur ; Michael D. SPENCER, Auteur Article en page(s) : p.1758-1772 Langues : Anglais (eng) Mots-clés : Autism Corpus callosum Handedness Asymmetry Lateralization Broader autism phenotype Index. décimale : PER Périodiques Résumé : Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization. En ligne : http://dx.doi.org/10.1007/s10803-012-1720-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1758-1772[article] Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited [Texte imprimé et/ou numérique] / Dorothea L. FLORIS, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur ; Michael D. SPENCER, Auteur . - p.1758-1772.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-8 (August 2013) . - p.1758-1772
Mots-clés : Autism Corpus callosum Handedness Asymmetry Lateralization Broader autism phenotype Index. décimale : PER Périodiques Résumé : Rightward cerebral lateralization has been suggested to be involved in the neuropathology of autism spectrum conditions. We investigated functional and neuroanatomical asymmetry, in terms of handedness and corpus callosum measurements in male adolescents with autism, their unaffected siblings and controls, and their associations with executive dysfunction and symptom severity. Adolescents with autism did not differ from controls in functional asymmetry, but neuroanatomically showed the expected pattern of stronger rightward lateralization in the posterior and anterior midbody based on their hand-preference. Measures of symptom severity were related to rightward asymmetry in three subregions (splenium, posterior midbody and rostral body). We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization. En ligne : http://dx.doi.org/10.1007/s10803-012-1720-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=205 Manual dexterity in children with autism spectrum disorder: A cross-syndrome approach / Daniel E. LIDSTONE in Research in Autism Spectrum Disorders, 73 (May 2019)
[article]
Titre : Manual dexterity in children with autism spectrum disorder: A cross-syndrome approach Type de document : Texte imprimé et/ou numérique Auteurs : Daniel E. LIDSTONE, Auteur ; Faria Z. MIAH, Auteur ; Brach POSTON, Auteur ; Julie F. BEASLEY, Auteur ; Janet S. DUFEK, Auteur Article en page(s) : 101546 Langues : Anglais (eng) Mots-clés : Cross-syndrome Manual dexterity FASD ASD Asymmetry Index. décimale : PER Périodiques Résumé : Background Manual dexterity (MD) is important for performing most activities of daily living, and children with ASD show MD deficits. However, the specificity of MD deficits in children with ASD has not previously been examined. Similar to children with ASD, extant evidence suggests children with Fetal Alcohol Spectrum Disorder (FASD) and Attention-Deficit Hyperactivity Disorder (ADHD) also show MD impairments. The purpose of this study was to examine the specificity MD deficits in children with ASD using a cross-syndrome design. We examined dominant (D) and non-dominant (ND) hand performance using a relatively large sample of children with ASD, FASD, ADHD, and typically developing (TD) children. Method Seventy-two right-handed children (7–17 years old) participated in this study. To examine MD, the 9-hole pegboard test was completed on the D and ND-hands. The fastest time of three attempts was recorded. HPA was defined as the percent difference between D and ND-hand times. Results D-hand MD was significantly worse in children with ASD vs. typically developing (TD) children (p?=?0.002). ND-hand dexterity was significantly worse in children with ASD vs. FASD (p?=?0.049) and TD groups (p?=?0.004). Hand performance asymmetry (HPA) was significantly lower in the FASD group compared to both the ASD and ADHD groups (p?0.05). Conclusions These results show that children with ASD show specific deficits in MD not observed in children with FASD or ADHD. Furthermore, HPA was found to be a sensitive measure to prenatal alcohol exposure. Neurobiological mechanisms of ASD and FASD are discussed. En ligne : https://doi.org/10.1016/j.rasd.2020.101546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421
in Research in Autism Spectrum Disorders > 73 (May 2019) . - 101546[article] Manual dexterity in children with autism spectrum disorder: A cross-syndrome approach [Texte imprimé et/ou numérique] / Daniel E. LIDSTONE, Auteur ; Faria Z. MIAH, Auteur ; Brach POSTON, Auteur ; Julie F. BEASLEY, Auteur ; Janet S. DUFEK, Auteur . - 101546.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 73 (May 2019) . - 101546
Mots-clés : Cross-syndrome Manual dexterity FASD ASD Asymmetry Index. décimale : PER Périodiques Résumé : Background Manual dexterity (MD) is important for performing most activities of daily living, and children with ASD show MD deficits. However, the specificity of MD deficits in children with ASD has not previously been examined. Similar to children with ASD, extant evidence suggests children with Fetal Alcohol Spectrum Disorder (FASD) and Attention-Deficit Hyperactivity Disorder (ADHD) also show MD impairments. The purpose of this study was to examine the specificity MD deficits in children with ASD using a cross-syndrome design. We examined dominant (D) and non-dominant (ND) hand performance using a relatively large sample of children with ASD, FASD, ADHD, and typically developing (TD) children. Method Seventy-two right-handed children (7–17 years old) participated in this study. To examine MD, the 9-hole pegboard test was completed on the D and ND-hands. The fastest time of three attempts was recorded. HPA was defined as the percent difference between D and ND-hand times. Results D-hand MD was significantly worse in children with ASD vs. typically developing (TD) children (p?=?0.002). ND-hand dexterity was significantly worse in children with ASD vs. FASD (p?=?0.049) and TD groups (p?=?0.004). Hand performance asymmetry (HPA) was significantly lower in the FASD group compared to both the ASD and ADHD groups (p?0.05). Conclusions These results show that children with ASD show specific deficits in MD not observed in children with FASD or ADHD. Furthermore, HPA was found to be a sensitive measure to prenatal alcohol exposure. Neurobiological mechanisms of ASD and FASD are discussed. En ligne : https://doi.org/10.1016/j.rasd.2020.101546 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 Right-lateralization of N2-amplitudes in depressive adolescents: an emotional go/no-go study / Monika TRINKL in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)
[article]
Titre : Right-lateralization of N2-amplitudes in depressive adolescents: an emotional go/no-go study Type de document : Texte imprimé et/ou numérique Auteurs : Monika TRINKL, Auteur ; Ellen GREIMEL, Auteur ; Jürgen BARTLING, Auteur ; Barbara GRÜNEWALD, Auteur ; Gerd SCHULTE-KÖRNE, Auteur ; Nicola GROSSHEINRICH, Auteur Article en page(s) : p.76-86 Langues : Anglais (eng) Mots-clés : ERP MDD major depression emotion regulation asymmetry left frontal hypoactivation endophenotype sensation seeking experience seeking appetitive stimuli impulsivity adolescence go nogo Index. décimale : PER Périodiques Résumé : Background Recent studies have proposed the process of emotion regulation as a promising target to study the neurophysiological basis of adolescent depression. Emotion regulation has repeatedly been studied with emotional go/no-go paradigms. To date, no study has examined if the left-frontal hypoactivation associated with depression generalizes to active tasks. The aim of this study was therefore to investigate the hemispheric asymmetry of the N2 component in depressed adolescents in an emotion regulation paradigm. Methods Twenty-four adolescents diagnosed with major depression (age 11–18) and 30 healthy controls (age 11–18) performed two emotional go/no-go tasks exhibiting negative faces as go trials and positive faces as no-go trials and vice versa. Results On the behavioral level, no significant group differences emerged. On the neural level, we found a more right-lateralized N2-amplitude in depressed subjects, while it was more left-lateralized in controls. Furthermore, both groups showed a less negative N2-amplitude to positive no-go stimuli. Conclusion This study provides strong support for a general left-frontal hypoactivity in adolescent depression, which also applies to active emotional go/no-go paradigms. Furthermore, the less negative N2 to positive stimuli is consistent with a generally enhanced impulsivity of adolescents toward appetitive stimuli, which is possibly the base of the differential clinical pattern of adolescent in contrast to adult depression. En ligne : http://dx.doi.org/10.1111/jcpp.12282 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259
in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.76-86[article] Right-lateralization of N2-amplitudes in depressive adolescents: an emotional go/no-go study [Texte imprimé et/ou numérique] / Monika TRINKL, Auteur ; Ellen GREIMEL, Auteur ; Jürgen BARTLING, Auteur ; Barbara GRÜNEWALD, Auteur ; Gerd SCHULTE-KÖRNE, Auteur ; Nicola GROSSHEINRICH, Auteur . - p.76-86.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-1 (January 2015) . - p.76-86
Mots-clés : ERP MDD major depression emotion regulation asymmetry left frontal hypoactivation endophenotype sensation seeking experience seeking appetitive stimuli impulsivity adolescence go nogo Index. décimale : PER Périodiques Résumé : Background Recent studies have proposed the process of emotion regulation as a promising target to study the neurophysiological basis of adolescent depression. Emotion regulation has repeatedly been studied with emotional go/no-go paradigms. To date, no study has examined if the left-frontal hypoactivation associated with depression generalizes to active tasks. The aim of this study was therefore to investigate the hemispheric asymmetry of the N2 component in depressed adolescents in an emotion regulation paradigm. Methods Twenty-four adolescents diagnosed with major depression (age 11–18) and 30 healthy controls (age 11–18) performed two emotional go/no-go tasks exhibiting negative faces as go trials and positive faces as no-go trials and vice versa. Results On the behavioral level, no significant group differences emerged. On the neural level, we found a more right-lateralized N2-amplitude in depressed subjects, while it was more left-lateralized in controls. Furthermore, both groups showed a less negative N2-amplitude to positive no-go stimuli. Conclusion This study provides strong support for a general left-frontal hypoactivity in adolescent depression, which also applies to active emotional go/no-go paradigms. Furthermore, the less negative N2 to positive stimuli is consistent with a generally enhanced impulsivity of adolescents toward appetitive stimuli, which is possibly the base of the differential clinical pattern of adolescent in contrast to adult depression. En ligne : http://dx.doi.org/10.1111/jcpp.12282 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=259