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How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? / Nikki J. KIRKMAN in Journal of Autism and Developmental Disorders, 38-2 (February 2008)
[article]
Titre : How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? Type de document : Texte imprimé et/ou numérique Auteurs : Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur Année de publication : 2008 Article en page(s) : p.333-341 Langues : Anglais (eng) Mots-clés : Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome. En ligne : http://dx.doi.org/10.1007/s10803-007-0398-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318
in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341[article] How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome? [Texte imprimé et/ou numérique] / Nikki J. KIRKMAN, Auteur ; William M. MCMAHON, Auteur ; Janet E. LAINHART, Auteur ; Jane E. LIBBEY, Auteur ; Hilary H. COON, Auteur ; Thayne L. SWEETEN, Auteur ; Judith N. MILLER, Auteur ; Edward K. STEVENSON, Auteur ; Robert S. FUJINAMI, Auteur . - 2008 . - p.333-341.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 38-2 (February 2008) . - p.333-341
Mots-clés : Autism Tourette-Syndrome Autoantibody Glial-fibrillary-acidic-protein Immunoglobulin Index. décimale : PER Périodiques Résumé : Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome. En ligne : http://dx.doi.org/10.1007/s10803-007-0398-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=318