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Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay / Kristen LYALL in Journal of Autism and Developmental Disorders, 44-7 (July 2014)
[article]
Titre : Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay Type de document : Texte imprimé et/ou numérique Auteurs : Kristen LYALL, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Article en page(s) : p.1546-1555 Langues : Anglais (eng) Mots-clés : Autoimmune disease Asthma Allergy Autism Developmental delay Maternal risk factors Index. décimale : PER Périodiques Résumé : The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD). En ligne : http://dx.doi.org/10.1007/s10803-013-2017-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236
in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1546-1555[article] Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay [Texte imprimé et/ou numérique] / Kristen LYALL, Auteur ; Paul ASHWOOD, Auteur ; Judy VAN DE WATER, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - p.1546-1555.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1546-1555
Mots-clés : Autoimmune disease Asthma Allergy Autism Developmental delay Maternal risk factors Index. décimale : PER Périodiques Résumé : The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD). En ligne : http://dx.doi.org/10.1007/s10803-013-2017-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 Autism and lack of D3 vitamin: A systematic review / G. PIOGGIA in Research in Autism Spectrum Disorders, 8-12 (December 2014)
[article]
Titre : Autism and lack of D3 vitamin: A systematic review Type de document : Texte imprimé et/ou numérique Auteurs : G. PIOGGIA, Auteur ; A. TONACCI, Auteur ; G. TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; F. MURATORI, Auteur ; L. RUTA, Auteur ; S. GANGEMI, Auteur Article en page(s) : p.1685-1698 Langues : Anglais (eng) Mots-clés : Autism Autoimmune disease Brain function Cholecalciferol Neurodevelopmental disorders Vitamin D3 Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. Several medical conditions including gastrointestinal (GI) problems, asthma and allergies have been associated with ASD, and multiple risk factors, both genetic and environmental, have been proposed. Among them, vitamin D (VD) deficiency is probably associated with ASD, and may play a role in the condition. We conducted a systematic review of the literature for the period January 1, 2010 through June 15, 2014, according to PRISMA guidelines, aiming to investigate the complex biological interplay between VD, metabolism, immune system and nervous system in ASD. Different trends in the association between ASD and VD deficiency have been observed, and factors such as gender, ethnicity, sampling, and methodology play a role in the results and outcomes. At present, for at least a subgroup of ASD individuals, an imbalance in VD metabolism probably exists and may be associated with the condition. In this cohort, VD replacement in these individuals might contribute to improving ASD symptoms and/or associated conditions. This topic is an important challenge for future research, and could lead to a new tailored therapeutic approach for VD in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243
in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1685-1698[article] Autism and lack of D3 vitamin: A systematic review [Texte imprimé et/ou numérique] / G. PIOGGIA, Auteur ; A. TONACCI, Auteur ; G. TARTARISCO, Auteur ; Lucia BILLECI, Auteur ; F. MURATORI, Auteur ; L. RUTA, Auteur ; S. GANGEMI, Auteur . - p.1685-1698.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 8-12 (December 2014) . - p.1685-1698
Mots-clés : Autism Autoimmune disease Brain function Cholecalciferol Neurodevelopmental disorders Vitamin D3 Index. décimale : PER Périodiques Résumé : Abstract Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and restricted, repetitive patterns of behavior. Several medical conditions including gastrointestinal (GI) problems, asthma and allergies have been associated with ASD, and multiple risk factors, both genetic and environmental, have been proposed. Among them, vitamin D (VD) deficiency is probably associated with ASD, and may play a role in the condition. We conducted a systematic review of the literature for the period January 1, 2010 through June 15, 2014, according to PRISMA guidelines, aiming to investigate the complex biological interplay between VD, metabolism, immune system and nervous system in ASD. Different trends in the association between ASD and VD deficiency have been observed, and factors such as gender, ethnicity, sampling, and methodology play a role in the results and outcomes. At present, for at least a subgroup of ASD individuals, an imbalance in VD metabolism probably exists and may be associated with the condition. In this cohort, VD replacement in these individuals might contribute to improving ASD symptoms and/or associated conditions. This topic is an important challenge for future research, and could lead to a new tailored therapeutic approach for VD in ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.09.003 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243