Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
4 recherche sur le mot-clé 'Autoimmunity'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study / Ryad TAMOUZA in Autism Research, 13-2 (February 2020)
[article]
Titre : HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study Type de document : Texte imprimé et/ou numérique Auteurs : Ryad TAMOUZA, Auteur ; Elisabeth FERNELL, Auteur ; Mats Anders ERIKSSON, Auteur ; Britt-Marie ANDERLID, Auteur ; Celine MANIER, Auteur ; Christina Mary MARIASELVAM, Auteur ; Wahid BOUKOUACI, Auteur ; Marion LEBOYER, Auteur ; Christopher GILLBERG, Auteur Article en page(s) : p.182-186 Langues : Anglais (eng) Mots-clés : autism spectrum disorders autoimmunity haplotypes human leucocyte antigens inflammation regression Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) comprises heterogeneous neurodevelopmental conditions with symptom onset usually during infancy. However, about 10%-30% of affected cases experience a loss of language and social skills around 18-30 months, so-called regressive autism. In this subset with regression, immune dysfunctions including inflammation and autoimmunity have been proposed to be at risk factors. Given the implication of the human histocompatibility antigens (HLA) system in various aspects of immune responses, including autoimmunity, and in ASD, we investigate here the distribution of the HLA Class I and Class II haplotypes in 131 children with ASD meeting DSM-IV TR criteria, with and without regression. We found that 62 of the 98 non-regressive ASD patients carry the HLA-DPA1*01-DPB1*04 sub-haplotype as compared to 14 of the 33 patients with regression (63% vs. 43% respectively, Pc = 0.02), suggesting that this HLA haplotype may exert a protective effect against regression. Similarly, the HLA-DPA1*01-DPB1*04 has also been found to be more represented in healthy controls as compared to patients affected with common nonpsychiatric autoimmune disorders. Overall our findings suggest a possible involvement of HLA polymorphism in the context of regressive ASD. Autism Res 2020, 13: 182-186. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Immune dysfunctions including inflammatory and autoimmune processes have been reported in autism, particularly in regressive forms. In this study, we analyzed the distribution of HLA haplotypes among children with autism spectrum disorder (ASD), with and without regression from Sweden and observed that HLA-DPA1*01-DPB1*04 sub-haplotype was less represented in patients with regressive autism as compared with those without regression. Such possible protective effect, also observed in other common autoimmune disorders, may constitute a link between HLA-mediated immune processes and regressive ASD. En ligne : http://dx.doi.org/10.1002/aur.2217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420
in Autism Research > 13-2 (February 2020) . - p.182-186[article] HLA Polymorphism in Regressive and Non-Regressive Autism: A Preliminary Study [Texte imprimé et/ou numérique] / Ryad TAMOUZA, Auteur ; Elisabeth FERNELL, Auteur ; Mats Anders ERIKSSON, Auteur ; Britt-Marie ANDERLID, Auteur ; Celine MANIER, Auteur ; Christina Mary MARIASELVAM, Auteur ; Wahid BOUKOUACI, Auteur ; Marion LEBOYER, Auteur ; Christopher GILLBERG, Auteur . - p.182-186.
Langues : Anglais (eng)
in Autism Research > 13-2 (February 2020) . - p.182-186
Mots-clés : autism spectrum disorders autoimmunity haplotypes human leucocyte antigens inflammation regression Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) comprises heterogeneous neurodevelopmental conditions with symptom onset usually during infancy. However, about 10%-30% of affected cases experience a loss of language and social skills around 18-30 months, so-called regressive autism. In this subset with regression, immune dysfunctions including inflammation and autoimmunity have been proposed to be at risk factors. Given the implication of the human histocompatibility antigens (HLA) system in various aspects of immune responses, including autoimmunity, and in ASD, we investigate here the distribution of the HLA Class I and Class II haplotypes in 131 children with ASD meeting DSM-IV TR criteria, with and without regression. We found that 62 of the 98 non-regressive ASD patients carry the HLA-DPA1*01-DPB1*04 sub-haplotype as compared to 14 of the 33 patients with regression (63% vs. 43% respectively, Pc = 0.02), suggesting that this HLA haplotype may exert a protective effect against regression. Similarly, the HLA-DPA1*01-DPB1*04 has also been found to be more represented in healthy controls as compared to patients affected with common nonpsychiatric autoimmune disorders. Overall our findings suggest a possible involvement of HLA polymorphism in the context of regressive ASD. Autism Res 2020, 13: 182-186. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: Immune dysfunctions including inflammatory and autoimmune processes have been reported in autism, particularly in regressive forms. In this study, we analyzed the distribution of HLA haplotypes among children with autism spectrum disorder (ASD), with and without regression from Sweden and observed that HLA-DPA1*01-DPB1*04 sub-haplotype was less represented in patients with regressive autism as compared with those without regression. Such possible protective effect, also observed in other common autoimmune disorders, may constitute a link between HLA-mediated immune processes and regressive ASD. En ligne : http://dx.doi.org/10.1002/aur.2217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=420 Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders / N.M. SHAKER in Autism - Open Access, 6-5 ([01/09/2016])
[article]
Titre : Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : N.M. SHAKER, Auteur ; G.R.A TAHA, Auteur ; H. KHOLEIF, Auteur ; N.M. SAYED, Auteur ; N.M. EL-SHEIKH, Auteur ; M.L. ABULMAGD, Auteur Article en page(s) : 7 p. Langues : Anglais (eng) Mots-clés : ASD Autoimmunity S100B protein Interleukin-6 Anti-transglutaminase antibody Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder. Various immune components and mediators have been investigated in ASD with controversial results. The purpose of this study was to: 1) investigate the levels of S100B protein (as a marker of neuronal damage), IgA autoantibodies to transglutaminase II (TG2) (as an indicator for presence of autoimmunity) and interleukin 6 (IL-6) (a pro-inflammatory cytokine), in sera of a group of autistic children, 2) explore the relation between serum levels of these parameters and severity of autism, 3) find out if there is any association between serum levels of S100B protein, IL-6 and TG2 IgA which might give clue to their pathogenic role in ASD. Methods: The levels of S100B protein, IL-6 and TG2 IgA were measured in the sera of 30 autistic children aged from 3 to 14 years. These levels were compared to those of 22 matched healthy children aged from 3 to 13 years. Assessment of clinical parameters and severity of autism was done using Gilliam Autism Rating Scale. Results: Autistic children showed higher significant serum S100B protein and IL-6 levels compared to healthy controls (P=0.003 and 0.002 respectively). No significant correlations were found between serum levels of S100B, IL-6, TG2 IgA and clinical parameters/severity of autism. Serum levels of S100B had significant negative correlation with TG2 IgA levels (P=0.037) and marginally significant positive correlation with IL-6 levels (P=0.05).Conclusion: The significant elevations of S100B and IL-6 levels in sera of autistic children possibly imply an underlying neuropathological condition in autistic patients. Anti-TG2 antibodies may not have a possible contributing role in some ASD children. More research is needed to investigate any possible link between serum S100B protein, IL-6 levels and other brain autoantibodies as potential indicators of brain autoimmunity in ASD patients. En ligne : https://dx.doi.org/10.4172/2165-7890.1000191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410
in Autism - Open Access > 6-5 [01/09/2016] . - 7 p.[article] Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders [Texte imprimé et/ou numérique] / N.M. SHAKER, Auteur ; G.R.A TAHA, Auteur ; H. KHOLEIF, Auteur ; N.M. SAYED, Auteur ; N.M. EL-SHEIKH, Auteur ; M.L. ABULMAGD, Auteur . - 7 p.
Langues : Anglais (eng)
in Autism - Open Access > 6-5 [01/09/2016] . - 7 p.
Mots-clés : ASD Autoimmunity S100B protein Interleukin-6 Anti-transglutaminase antibody Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder. Various immune components and mediators have been investigated in ASD with controversial results. The purpose of this study was to: 1) investigate the levels of S100B protein (as a marker of neuronal damage), IgA autoantibodies to transglutaminase II (TG2) (as an indicator for presence of autoimmunity) and interleukin 6 (IL-6) (a pro-inflammatory cytokine), in sera of a group of autistic children, 2) explore the relation between serum levels of these parameters and severity of autism, 3) find out if there is any association between serum levels of S100B protein, IL-6 and TG2 IgA which might give clue to their pathogenic role in ASD. Methods: The levels of S100B protein, IL-6 and TG2 IgA were measured in the sera of 30 autistic children aged from 3 to 14 years. These levels were compared to those of 22 matched healthy children aged from 3 to 13 years. Assessment of clinical parameters and severity of autism was done using Gilliam Autism Rating Scale. Results: Autistic children showed higher significant serum S100B protein and IL-6 levels compared to healthy controls (P=0.003 and 0.002 respectively). No significant correlations were found between serum levels of S100B, IL-6, TG2 IgA and clinical parameters/severity of autism. Serum levels of S100B had significant negative correlation with TG2 IgA levels (P=0.037) and marginally significant positive correlation with IL-6 levels (P=0.05).Conclusion: The significant elevations of S100B and IL-6 levels in sera of autistic children possibly imply an underlying neuropathological condition in autistic patients. Anti-TG2 antibodies may not have a possible contributing role in some ASD children. More research is needed to investigate any possible link between serum S100B protein, IL-6 levels and other brain autoantibodies as potential indicators of brain autoimmunity in ASD patients. En ligne : https://dx.doi.org/10.4172/2165-7890.1000191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 Bidirectional relationship between eating disorders and autoimmune diseases / A. HEDMAN in Journal of Child Psychology and Psychiatry, 60-7 (July 2019)
[article]
Titre : Bidirectional relationship between eating disorders and autoimmune diseases Type de document : Texte imprimé et/ou numérique Auteurs : A. HEDMAN, Auteur ; L. BREITHAUPT, Auteur ; C. HUBEL, Auteur ; L. M. THORNTON, Auteur ; A. TILLANDER, Auteur ; C. NORRING, Auteur ; A. BIRGEGARD, Auteur ; H. LARSSON, Auteur ; J. F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur Article en page(s) : p.803-812 Langues : Anglais (eng) Mots-clés : anorexia nervosa autoimmunity bulimia nervosa cox regression hazard immune system risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812[article] Bidirectional relationship between eating disorders and autoimmune diseases [Texte imprimé et/ou numérique] / A. HEDMAN, Auteur ; L. BREITHAUPT, Auteur ; C. HUBEL, Auteur ; L. M. THORNTON, Auteur ; A. TILLANDER, Auteur ; C. NORRING, Auteur ; A. BIRGEGARD, Auteur ; H. LARSSON, Auteur ; J. F. LUDVIGSSON, Auteur ; L. SAVENDAHL, Auteur ; Catarina ALMQVIST, Auteur ; Cynthia M. BULIK, Auteur . - p.803-812.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 60-7 (July 2019) . - p.803-812
Mots-clés : anorexia nervosa autoimmunity bulimia nervosa cox regression hazard immune system risk Index. décimale : PER Périodiques Résumé : BACKGROUND: Immune system dysfunction may be associated with eating disorders (ED) and could have implications for detection, risk assessment, and treatment of both autoimmune diseases and EDs. However, questions regarding the nature of the relationship between these two disease entities remain. We evaluated the strength of associations for the bidirectional relationships between EDs and autoimmune diseases. METHODS: In this nationwide population-based study, Swedish registers were linked to establish a cohort of more than 2.5 million individuals born in Sweden between January 1, 1979 and December 31, 2005 and followed up until December 2013. Cox proportional hazard regression models were used to investigate: (a) subsequent risk of EDs in individuals with autoimmune diseases; and (b) subsequent risk of autoimmune diseases in individuals with EDs. RESULTS: We observed a strong, bidirectional relationship between the two illness classes indicating that diagnosis in one illness class increased the risk of the other. In women, the diagnoses of autoimmune disease increased subsequent hazards of anorexia nervosa (AN), bulimia nervosa (BN), and other eating disorders (OED). Similarly, AN, BN, and OED increased subsequent hazards of autoimmune diseases.Gastrointestinal-related autoimmune diseases such as, celiac disease and Crohn's disease showed a bidirectional relationship with AN and OED. Psoriasis showed a bidirectional relationship with OED. The previous occurence of type 1 diabetes increased the risk for AN, BN, and OED. In men, we did not observe a bidirectional pattern, but prior autoimmune arthritis increased the risk for OED. CONCLUSIONS: The interactions between EDs and autoimmune diseases support the previously reported associations. The bidirectional risk pattern observed in women suggests either a shared mechanism or a third mediating variable contributing to the association of these illnesses. En ligne : http://dx.doi.org/10.1111/jcpp.12958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Titre : Immune Dysfunction in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur Année de publication : 2016 Importance : p.65-82 Langues : Anglais (eng) Mots-clés : Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Immune Dysfunction in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Natalia V. MALKOVA, Auteur ; Elaine Y. HSIAO, Auteur . - 2016 . - p.65-82.
in Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability / Carlo SALA
Langues : Anglais (eng)
Mots-clés : Autoimmunity Maternal immune activation Microglia Neuroimmunology Neuroinflammation Index. décimale : SCI-D SCI-D - Neurosciences Résumé : Autism spectrum disorder (ASD) is diagnosed based on abnormalities in social, communicative, and stereotyped behaviors, but a preponderance of evidence indicates that immune dysfunction is a key feature of ASD. In this chapter, we review the several cellular and functional immune alterations observed in the brains, periphery, and gastrointestinal tracts of ASD individuals. In addition, we highlight pathways for neuroimmune interactions and novel roles for immune factors in neurodevelopment. We further discuss immune-related environmental and genetic risk factors for ASD, along with findings from animal models that support a role for early life immune dysregulation in the etiopathogenesis of ASD symptoms. Finally, we outline results from clinical trials of immune-based therapies for ASD and consider future directions for investigating potential immune contributions to ASD diagnosis and treatment. En ligne : http://dx.doi.org/10.1016/B978-0-12-800109-7.00005-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=301 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire