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Research Review: The neurobiology and genetics of maltreatment and adversity / Eamon J. MCCRORY in Journal of Child Psychology and Psychiatry, 51-10 (October 2010)
[article]
Titre : Research Review: The neurobiology and genetics of maltreatment and adversity Type de document : Texte imprimé et/ou numérique Auteurs : Eamon J. MCCRORY, Auteur ; Stephane A. DE BRITO, Auteur Année de publication : 2010 Article en page(s) : p.1079-1095 Langues : Anglais (eng) Mots-clés : Child-abuse maltreatment neuroscience genetics HPA psychopathology resilience cortisol Index. décimale : PER Périodiques Résumé : The neurobiological mechanisms by which childhood maltreatment heightens vulnerability to psychopathology remain poorly understood. It is likely that a complex interaction between environmental experiences (including poor caregiving) and an individual’s genetic make-up influence neurobiological development across infancy and childhood, which in turn sets the stage for a child’s psychological and emotional development. This review provides a concise synopsis of those studies investigating the neurobiological and genetic factors associated with childhood maltreatment and adversity. We first provide an overview of the neuroendocrine findings, drawing from animal and human studies. These studies indicate an association between early adversity and atypical development of the hypothalamic-pituitary-adrenal (HPA) axis stress response, which can predispose to psychiatric vulnerability in adulthood. We then review the neuroimaging findings of structural and functional brain differences in children and adults who have experienced childhood maltreatment. These studies offer evidence of several structural differences associated with early stress, most notably in the corpus callosum in children and the hippocampus in adults; functional studies have reported atypical activation of several brain regions, including decreased activity of the prefrontal cortex. Next we consider studies that suggest that the effect of environmental adversity may be conditional on an individual’s genotype. We also briefly consider the possible role that epigenetic mechanisms might play in mediating the impact of early adversity. Finally we consider several ways in which the neurobiological and genetic research may be relevant to clinical practice and intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02271.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110
in Journal of Child Psychology and Psychiatry > 51-10 (October 2010) . - p.1079-1095[article] Research Review: The neurobiology and genetics of maltreatment and adversity [Texte imprimé et/ou numérique] / Eamon J. MCCRORY, Auteur ; Stephane A. DE BRITO, Auteur . - 2010 . - p.1079-1095.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 51-10 (October 2010) . - p.1079-1095
Mots-clés : Child-abuse maltreatment neuroscience genetics HPA psychopathology resilience cortisol Index. décimale : PER Périodiques Résumé : The neurobiological mechanisms by which childhood maltreatment heightens vulnerability to psychopathology remain poorly understood. It is likely that a complex interaction between environmental experiences (including poor caregiving) and an individual’s genetic make-up influence neurobiological development across infancy and childhood, which in turn sets the stage for a child’s psychological and emotional development. This review provides a concise synopsis of those studies investigating the neurobiological and genetic factors associated with childhood maltreatment and adversity. We first provide an overview of the neuroendocrine findings, drawing from animal and human studies. These studies indicate an association between early adversity and atypical development of the hypothalamic-pituitary-adrenal (HPA) axis stress response, which can predispose to psychiatric vulnerability in adulthood. We then review the neuroimaging findings of structural and functional brain differences in children and adults who have experienced childhood maltreatment. These studies offer evidence of several structural differences associated with early stress, most notably in the corpus callosum in children and the hippocampus in adults; functional studies have reported atypical activation of several brain regions, including decreased activity of the prefrontal cortex. Next we consider studies that suggest that the effect of environmental adversity may be conditional on an individual’s genotype. We also briefly consider the possible role that epigenetic mechanisms might play in mediating the impact of early adversity. Finally we consider several ways in which the neurobiological and genetic research may be relevant to clinical practice and intervention. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02271.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=110