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Autism and Phthalate Metabolite Glucuronidation / T. Peter STEIN in Journal of Autism and Developmental Disorders, 43-11 (November 2013)
[article]
Titre : Autism and Phthalate Metabolite Glucuronidation Type de document : Texte imprimé et/ou numérique Auteurs : T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Xue MING, Auteur Article en page(s) : p.2677-2685 Langues : Anglais (eng) Mots-clés : Diethylhexyl phthalate Phthalates Autism Glucuronidation Index. décimale : PER Périodiques Résumé : Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1822-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217
in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2677-2685[article] Autism and Phthalate Metabolite Glucuronidation [Texte imprimé et/ou numérique] / T. Peter STEIN, Auteur ; Margaret D. SCHLUTER, Auteur ; Robert A. STEER, Auteur ; Xue MING, Auteur . - p.2677-2685.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2677-2685
Mots-clés : Diethylhexyl phthalate Phthalates Autism Glucuronidation Index. décimale : PER Périodiques Résumé : Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured the efficiency of glucuronidation for a series of metabolites derived from the commonly used plasticizer, diethylhexyl phthalate. Spot urines were collected and analyzed for the fraction of each metabolite conjugated by isotope dilution-liquid chromatography mass spectrometry-mass spectrometry. The degree of glucuronidation was lower with the ASD group. The glucuronidation pathway may differ in some children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1822-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217