Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
3 recherche sur le mot-clé 'Drosophila melanogaster'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems / David H. SKUSE in Journal of Child Psychology and Psychiatry, 41-1 (January 2000)
[article]
Titre : Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems Type de document : Texte imprimé et/ou numérique Auteurs : David H. SKUSE, Auteur Année de publication : 2000 Article en page(s) : p.3-31 Langues : Anglais (eng) Mots-clés : Behavioural neuroscience neurogenetics model systems Drosophila melanogaster Caenorhabditis elegans laboratory mouse Index. décimale : PER Périodiques Résumé : We have just emerged from “the Decade of the Brain”, yet in so many ways it was the “Decade of the Genome”. What relevance does the remarkable advance in knowledge in genetics and neuroscience over that period have to our understanding of child psychopathology? When the complexity of the genetic systems involved in behavioural regulation of relatively simple organisms such as the nematode worm Caenorhabditis elegans or the fruitfly Drosophila melanogaster is considered, the possibility of comprehending the links from genes to behaviour in the developing child seems remote. Yet, the principles of investigation in model systems are not so different to those that should apply in humans. This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125
in Journal of Child Psychology and Psychiatry > 41-1 (January 2000) . - p.3-31[article] Behavioural Neuroscience and Child Psychopathology: Insights from Model Systems [Texte imprimé et/ou numérique] / David H. SKUSE, Auteur . - 2000 . - p.3-31.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 41-1 (January 2000) . - p.3-31
Mots-clés : Behavioural neuroscience neurogenetics model systems Drosophila melanogaster Caenorhabditis elegans laboratory mouse Index. décimale : PER Périodiques Résumé : We have just emerged from “the Decade of the Brain”, yet in so many ways it was the “Decade of the Genome”. What relevance does the remarkable advance in knowledge in genetics and neuroscience over that period have to our understanding of child psychopathology? When the complexity of the genetic systems involved in behavioural regulation of relatively simple organisms such as the nematode worm Caenorhabditis elegans or the fruitfly Drosophila melanogaster is considered, the possibility of comprehending the links from genes to behaviour in the developing child seems remote. Yet, the principles of investigation in model systems are not so different to those that should apply in humans. This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=125 From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes / Benjamin HARICH in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)
[article]
Titre : From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin HARICH, Auteur ; Marieke KLEIN, Auteur ; Charlotte W. OCKELOEN, Auteur ; Monique VAN DER VOET, Auteur ; Marlies SCHIMMEL-NABER, Auteur ; Nicole DE LEEUW, Auteur ; Annette SCHENCK, Auteur ; Barbara FRANKE, Auteur Article en page(s) : p.545-555 Langues : Anglais (eng) Mots-clés : Drosophila melanogaster Fbxo25 Tdrp Adhd psychiatric comorbidities Index. décimale : PER Périodiques Résumé : BACKGROUND: Mental disorders, including Attention-Deficit/Hyperactivity Disorder (ADHD), have a complex etiology, and identification of underlying genetic risk factors is challenging. This study used a multistep approach to identify and validate a novel risk gene for ADHD and psychiatric comorbidity. METHODS: In a single family, severely affected by ADHD and cooccurring disorders, we applied single nucleotide polymorphism (SNP)-array analysis to detect copy-number variations (CNVs) linked to disease. Genes present in the identified CNV were subsequently tested for their association with ADHD in the largest data set currently available (n = 55,374); this gene-set and gene-based association analyses were based on common genetic variants. Significant findings were taken forward for functional validation using Drosophila melanogaster as biological model system, altering gene expression using the GAL4-UAS system and a pan-neuronal driver, and subsequently characterizing locomotor activity and sleep as functional readouts. RESULTS: We identified a copy number gain in 8p23.3, which segregated with psychiatric phenotypes in the family and was confirmed by quantitative RT-PCR. Common genetic variants in this locus were associated with ADHD, especially those in FBXO25 and TDRP. Overexpression of the FBXO25 orthologue in two Drosophila models consistently led to increased locomotor activity and reduced sleep compared with the genetic background control. CONCLUSIONS: We combine ADHD risk gene identification in an individual family with genetic association testing in a large case-control data set and functional validation in a model system, together providing an important illustration of an integrative approach suggesting that FBXO25 contributes to key features of ADHD and comorbid neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.545-555[article] From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes [Texte imprimé et/ou numérique] / Benjamin HARICH, Auteur ; Marieke KLEIN, Auteur ; Charlotte W. OCKELOEN, Auteur ; Monique VAN DER VOET, Auteur ; Marlies SCHIMMEL-NABER, Auteur ; Nicole DE LEEUW, Auteur ; Annette SCHENCK, Auteur ; Barbara FRANKE, Auteur . - p.545-555.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.545-555
Mots-clés : Drosophila melanogaster Fbxo25 Tdrp Adhd psychiatric comorbidities Index. décimale : PER Périodiques Résumé : BACKGROUND: Mental disorders, including Attention-Deficit/Hyperactivity Disorder (ADHD), have a complex etiology, and identification of underlying genetic risk factors is challenging. This study used a multistep approach to identify and validate a novel risk gene for ADHD and psychiatric comorbidity. METHODS: In a single family, severely affected by ADHD and cooccurring disorders, we applied single nucleotide polymorphism (SNP)-array analysis to detect copy-number variations (CNVs) linked to disease. Genes present in the identified CNV were subsequently tested for their association with ADHD in the largest data set currently available (n = 55,374); this gene-set and gene-based association analyses were based on common genetic variants. Significant findings were taken forward for functional validation using Drosophila melanogaster as biological model system, altering gene expression using the GAL4-UAS system and a pan-neuronal driver, and subsequently characterizing locomotor activity and sleep as functional readouts. RESULTS: We identified a copy number gain in 8p23.3, which segregated with psychiatric phenotypes in the family and was confirmed by quantitative RT-PCR. Common genetic variants in this locus were associated with ADHD, especially those in FBXO25 and TDRP. Overexpression of the FBXO25 orthologue in two Drosophila models consistently led to increased locomotor activity and reduced sleep compared with the genetic background control. CONCLUSIONS: We combine ADHD risk gene identification in an individual family with genetic association testing in a large case-control data set and functional validation in a model system, together providing an important illustration of an integrative approach suggesting that FBXO25 contributes to key features of ADHD and comorbid neuropsychiatric disorders. En ligne : http://dx.doi.org/10.1111/jcpp.13161 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 Invertebrate Models of Synaptic Transmission in Autism Spectrum Disorders / Manuel RUIZ-RUBIO
Titre : Invertebrate Models of Synaptic Transmission in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Manuel RUIZ-RUBIO, Auteur ; Fernando CALAHORRO, Auteur ; M. Mar GÁMEZ-DEL-ESTAL, Auteur Année de publication : 2015 Importance : p.157-182 Langues : Anglais (eng) Mots-clés : Drosophila melanogaster Aplysia californica Caenorhabditis elegans Green fluorescent protein Synapse RNAi silencing Gene targeting Neuroligin Neurexin Cognitive abilities Psychiatric disorders Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=265 Invertebrate Models of Synaptic Transmission in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Manuel RUIZ-RUBIO, Auteur ; Fernando CALAHORRO, Auteur ; M. Mar GÁMEZ-DEL-ESTAL, Auteur . - 2015 . - p.157-182.
Langues : Anglais (eng)
Mots-clés : Drosophila melanogaster Aplysia californica Caenorhabditis elegans Green fluorescent protein Synapse RNAi silencing Gene targeting Neuroligin Neurexin Cognitive abilities Psychiatric disorders Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=265 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire