Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
1 recherche sur le mot-clé 'GABBR1 GABRα4 GABRα5 GABRβ1 Autism Brain'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism / S. Hossein FATEMI in Journal of Autism and Developmental Disorders, 40-6 (June 2010)
[article]
Titre : mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism Type de document : Texte imprimé et/ou numérique Auteurs : S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur ; Robert J. ROONEY, Auteur ; Diven H. PATEL, Auteur Année de publication : 2010 Article en page(s) : p.743-750 Langues : Anglais (eng) Mots-clés : GABBR1 GABRα4 GABRα5 GABRβ1 Autism Brain Index. décimale : PER Périodiques Résumé : We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABΒR1). These results provide further evidence of impairment of GABAergic signaling in autism. En ligne : http://dx.doi.org/10.1007/s10803-009-0924-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102
in Journal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.743-750[article] mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism [Texte imprimé et/ou numérique] / S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur ; Robert J. ROONEY, Auteur ; Diven H. PATEL, Auteur . - 2010 . - p.743-750.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 40-6 (June 2010) . - p.743-750
Mots-clés : GABBR1 GABRα4 GABRα5 GABRβ1 Autism Brain Index. décimale : PER Périodiques Résumé : We have shown altered expression of gamma-aminobutyric acid A (GABAA) and gamma-aminobutyric acid B (GABAB) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABAA subunits previously associated with autism (GABRα4; GABRα5; GABRβ1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRα4, GABRα5, GABRβ1) and one demonstrated concordance in cerebellum (GABΒR1). These results provide further evidence of impairment of GABAergic signaling in autism. En ligne : http://dx.doi.org/10.1007/s10803-009-0924-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102