Centre d'Information et de documentation du CRA Rhône-Alpes
CRA
Informations pratiques
-
Adresse
Centre d'information et de documentation
du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
bât 211
95, Bd Pinel
69678 Bron CedexHoraires
Lundi au Vendredi
9h00-12h00 13h30-16h00Contact
Tél: +33(0)4 37 91 54 65
Mail
Fax: +33(0)4 37 91 54 37
-
Résultat de la recherche
1 recherche sur le mot-clé 'GABRA1 GABRA2 GABRA3 GABRB3 Autism Brain'
Affiner la recherche Générer le flux rss de la recherche
Partager le résultat de cette recherche Faire une suggestion
GABAa Receptor Downregulation in Brains of Subjects with Autism / S. Hossein FATEMI in Journal of Autism and Developmental Disorders, 39-2 (February 2009)
[article]
Titre : GABAa Receptor Downregulation in Brains of Subjects with Autism Type de document : Texte imprimé et/ou numérique Auteurs : S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur Année de publication : 2009 Article en page(s) : p.223-230 Langues : Anglais (eng) Mots-clés : GABRA1 GABRA2 GABRA3 GABRB3 Autism Brain Index. décimale : PER Périodiques Résumé : Gamma-aminobutyric acid A (GABAA) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABAA receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann’s Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABAA receptor subunit expression in the three brain areas. Our results demonstrate that GABAA receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism. En ligne : http://dx.doi.org/10.1007/s10803-008-0646-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683
in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.223-230[article] GABAa Receptor Downregulation in Brains of Subjects with Autism [Texte imprimé et/ou numérique] / S. Hossein FATEMI, Auteur ; Teri J. REUTIMAN, Auteur ; Timothy D. FOLSOM, Auteur ; Paul D. THURAS, Auteur . - 2009 . - p.223-230.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-2 (February 2009) . - p.223-230
Mots-clés : GABRA1 GABRA2 GABRA3 GABRB3 Autism Brain Index. décimale : PER Périodiques Résumé : Gamma-aminobutyric acid A (GABAA) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABAA receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann’s Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABAA receptor subunit expression in the three brain areas. Our results demonstrate that GABAA receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism. En ligne : http://dx.doi.org/10.1007/s10803-008-0646-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=683